Single-Molecule Kinetics Reveals a Hidden Surface Reaction Intermediate in Single-Nanoparticle Catalysis

2014 ◽  
Vol 118 (46) ◽  
pp. 26902-26911 ◽  
Author(s):  
Hao Shen ◽  
Xiaochun Zhou ◽  
Ningmu Zou ◽  
Peng Chen
Keyword(s):  
Single Molecule ◽  
Surface Reaction ◽  
Reaction Intermediate ◽  
Single Nanoparticle ◽  
Nanoparticle Catalysis

scholarly journals A nanofluidic device for parallel single nanoparticle catalysis in solution

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Sune Levin ◽  
Joachim Fritzsche ◽  
Sara Nilsson ◽  
August Runemark ◽  
Bhausaheb Dhokale ◽  
...  
Keyword(s):  
Single Particle ◽  
Surface Reaction ◽  
Reaction Rates ◽  
Reaction Conditions ◽  
Inherent Limitation ◽  
Catalyst Nanoparticles ◽  
Single Nanoparticle ◽  
Promising Application ◽  
Nanoparticle Catalysis ◽  
Nanofluidic Device

Abstract Studying single catalyst nanoparticles, during reaction, eliminates averaging effects that are an inherent limitation of ensemble experiments. It enables establishing structure–function correlations beyond averaged properties by including particle-specific descriptors such as defects, chemical heterogeneity and microstructure. Driven by these prospects, several single particle catalysis concepts have been implemented. However, they all have limitations such as low throughput, or that they require very low reactant concentrations and/or reaction rates. In response, we present a nanofluidic device for highly parallelized single nanoparticle catalysis in solution, based on fluorescence microscopy. Our device enables parallel scrutiny of tens of single nanoparticles, each isolated inside its own nanofluidic channel, and at tunable reaction conditions, ranging from the fully mass transport limited regime to the surface reaction limited regime. In a wider perspective, our concept provides a versatile platform for highly parallelized single particle catalysis in solution and constitutes a promising application area for nanofluidics.

Single-molecule spectroscopy

2017 ◽  
Author(s):  
Michel Orrit
Keyword(s):  
Nonlinear Optics ◽  
Single Molecule ◽  
Single Molecules ◽  
Super Resolution ◽  
Optical Methods ◽  
Single Molecule Spectroscopy ◽  
New Techniques ◽  
Single Nanoparticle ◽  
Cell Biologist ◽  
Sensitivity And Selectivity

This chapter gives an overview of the main optical methods used to detect and study single molecules and other small objects (nano-objects). Much of the work so far has exploited the excellent sensitivity and selectivity of fluorescence, but several new techniques, mostly based on nonlinear optics, have recently reached the single-molecule or single-nanoparticle regime. The chapter briefly discusses some results with reference to published reviews. Single-molecule techniques have now been incorporated into the arsenal of the physico-chemist and the cell biologist. However, the recent development of super-resolution techniques and of new labels suggests that further progress can be expected from measurements on single nano-objects in the next few years.

scholarly journals Single-molecule kinetics of nanoparticle catalysis

Nano Research ◽  
2009 ◽  
Vol 2 (12) ◽  
pp. 911-922 ◽  
Author(s):  
Weilin Xu ◽  
Hao Shen ◽  
Guokun Liu ◽  
Peng Chen
Keyword(s):  
Single Molecule ◽  
Nanoparticle Catalysis ◽  
Kinetics Of

Synthetic Glass Nanopore for Single Molecule Detection

2012 ◽  
Vol 229-231 ◽  
pp. 197-200
Author(s):  
Xiu Hua Sun ◽  
Chang Lu Gao ◽  
Li Qun Gu
Keyword(s):  
Pore Structure ◽  
Single Molecule ◽  
Second Messengers ◽  
Single Molecule Detection ◽  
Target Species ◽  
Single Nanoparticle ◽  
Molecular Scale ◽  
Drug Compounds ◽  
Target Molecules ◽  
Nanopore Sensors

The molecular-scale pore structure, called nanopore, interacting with target molecules in its functionalized lumen, can produce characteristic changes in the pore conductance, which allows us to identify single molecules and simultaneously quantify each target species in the mixture. Nanopore sensors have been created for tremendous biomedical detections, with targets ranging from metal ions, drug compounds and cellular second messengers, to proteins and DNAs. Here we will review our recent discoveries with a lab-in-hand glass nanopore: single-molecule discrimination of chiral enantiomers with a trapped cyclodextrin, sensing of bioterrorist agent ricin and site-directed capturing a single nanoparticle.

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