Reversible Cross-Linking, Microdomain Structure, and Heterogeneous Dynamics in Thermally Reversible Cross-Linked Polyurethane as Revealed by Solid-State NMR

2014 ◽  
Vol 118 (4) ◽  
pp. 1126-1137 ◽  
Author(s):  
Rongchun Zhang ◽  
Shen Yu ◽  
Shengli Chen ◽  
Qiang Wu ◽  
Tiehong Chen ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Cross Linking ◽  
Heterogeneous Dynamics ◽  
Microdomain Structure

Development and Characterization of LBG-PVA Interpenetrating Networks Incorporating Gliclazide for Sustained Release

2020 ◽  
Vol 15 ◽  
Author(s):  
Ashish Katoch ◽  
Manju Nagpal ◽  
Malkiet Kaur ◽  
Manjinder Singh ◽  
Geeta Aggarwal ◽  
...  
Keyword(s):  
Solid State ◽  
Sustained Release ◽  
Half Life ◽  
Solid State Nmr ◽  
Oral Dosage ◽  
Cross Linking ◽  
Interpenetrating Networks ◽  
Dsc Studies ◽  
Biological Half Life ◽  
Percentage Yield

Background: Controlled oral dosage forms have always been preferred for drugs with variable absorption, and short biological half life and frequent dosing. The prime goal with sustained release systems is to maintain uniform therapeutic blood levels for longer periods of time. Interpenetrating networks (IPNs) have been evidenced as uniform sustained release systems. In current study, polyvinyl alcohol (PVA) and locust bean gum (LBG) based IPNs were developed for the oral sustained release drug delivery of gliclazide (shows variable absorption). Method: The IPNs were synthesized by emulsion cross-linking method using glutaraldehyde (GA) as a cross linking agent. Gliclazide is a potential second generation, short-acting sulfonylurea oral hypoglycemic agent is having a short biological half-life (2-4 h), variable absorption and poor oral bioavailability. Various batches of IPNs were formulated by varying LBG: PVA ratio and evaluated for percentage yield, drug entrapment efficiency (DEE), swelling properties and in vitro drug release studies. Further characterizations were done by Fourier Transform Infrared Spectroscopy (FTIR), C13 Solid state NMR, X-Ray diffraction study (XRD), Scanning electron microscopy (SEM), and Differential scanning microscopy (DSC) studies. Results: The percentage yield, drug entrapment and equilibrium swelling was observed to be dependent on PVA-LBG ratio and GA amount. Sustained release of drug was observed in all IPN formulations (approx 59 - 86% in 8 h in various batches) with variable release kinetics. SEM studies revealed the regular structures of IPNs. FTIR, XRD, C13 Solid state NMR and DSC studies proposed that drug was successfully incorporated into the formed IPNs. Conclusion: IPNs of LBG and PVA can be used as a promising carrier with uniform sustained release characteristics.

scholarly journals Characterization of the Cross-Linking Nylon-6,6 Blended Reactive Types of Flame Retardants with .GAMMA.-Ray Irradiation by Solid State NMR

2006 ◽  
Vol 63 (12) ◽  
pp. 799-804 ◽  
Author(s):  
Yuko MIWA ◽  
Hiroyuki ISHIDA ◽  
Toshiyuki KANNO ◽  
Hiromasa YANASE ◽  
Kiyotaka SHIGEHARA
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Flame Retardants ◽  
Gamma Ray ◽  
Cross Linking ◽  
Nylon 6,6 ◽  
Gamma Ray Irradiation ◽  
The Cross

Formation of carbamates and cross-linking of microbial poly(ε-l-lysine) studied by 13C and 15N solid-state NMR

2011 ◽  
Vol 68 (3) ◽  
pp. 745-754 ◽  
Author(s):  
Shiro Maeda ◽  
Shingo Oumae ◽  
Shota Kaneko ◽  
Ko-Ki Kunimoto
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Cross Linking

Solid-State NMR Analysis of Cross-Linking in Mussel Protein Glue

1993 ◽  
Vol 302 (1) ◽  
pp. 255-258 ◽  
Author(s):  
S.M. Holl ◽  
D. Hansen ◽  
J.H. Waite ◽  
J. Schaefer
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Cross Linking ◽  
Nmr Analysis

13C Solid-State NMR Determination of Cross-Linking Degree in Superabsorbing Cellulose-Based Networks

2000 ◽  
Vol 33 (2) ◽  
pp. 430-437 ◽  
Author(s):  
Donatella Capitani ◽  
Matteo Alessandro Del Nobile ◽  
Giuseppe Mensitieri ◽  
Alessandro Sannino ◽  
Anna Laura Segre
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Cross Linking
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