MALDI Mechanism of Dihydroxybenzoic Acid Isomers: Desorption of Neutral Matrix and Analyte

2013 ◽  
Vol 117 (17) ◽  
pp. 5058-5064 ◽  
Author(s):  
Chi Wei Liang ◽  
Chih Hao Lee ◽  
Yu-Jiun Lin ◽  
Yuan Tseh Lee ◽  
Chi Kung Ni
Keyword(s):  
Dihydroxybenzoic Acid ◽  
Maldi Mechanism

scholarly journals The effect of chelating agents on iron mobilization in Chang cell cultures

Blood ◽  
1976 ◽  
Vol 48 (6) ◽  
pp. 923-929 ◽  
Author(s):  
GP White ◽  
A Jacobs ◽  
RW Grady ◽  
A Cerami
Keyword(s):  
Cell Cultures ◽  
Chelating Agents ◽  
Transferrin Saturation ◽  
Molar Ratio ◽  
Iron Release ◽  
Dihydroxybenzoic Acid ◽  
Equal Degree ◽  
Therapeutic Value ◽  
Chang Cell

Abstract The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3- dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells. They are effective to an approximately equal degree. The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound. How far these phenomena relate to therapeutic potentially remains to be seen.

scholarly journals Impact of Advanced Oxidation Products on Nanofiltration Efficiency

Water ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 541 ◽  
Author(s):  
Renata Żyłła ◽  
Rafał Milala ◽  
Irena Kamińska ◽  
Marcin Kudzin ◽  
Marta Gmurek ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Membrane Filtration ◽  
Main Product ◽  
Membrane Separation ◽  
Negative Impact ◽  
Microscopic Analysis ◽  
Contact Angles ◽  
Oxidation Products ◽  
Acid Oxidation ◽  
Dihydroxybenzoic Acid

The aim of the work was to determine the influence of salicylic acid (SA) oxidation products on the effectiveness of their further removal in the membrane filtration process. Two commercial polyamide-based polymer membranes, HL (GE Osmonics) and TS80 (TriSepTM), were used and characterized by SEM microscopic analysis, contact angles, and free surface energy. The products of salicylic acid oxidation, 2,3- and 2,5-dihydroxybenzoic acid and catechol, were determined and their impact on the removal of unreacted salicylic acid in the nanofiltration process was investigated. It was also checked to what extent and why they were retained or not by the membranes. The results of the research have shown that the main product of salicylic acid oxidation, 2,3-dihydroxybenzoic acid, has a negative impact on the retention of salicylic acid in the nanofiltration stage, while the other product, catechol, improves SA retention. The determined values of contact angles correlate well with solubility (S) of the tested compounds, which increases in the following order SSA < S2,3-DHBA < SCAT, while the contact angle of the membrane decreases. Nevertheless, it has been shown that some oxidation products can penetrate the environment due to poorer membrane separation properties of these products.

Modulation of Experimental Phacoanaphylactic Endophthalmitis with the Antioxidants Sodium Benzoate, and 2,3-Dihydroxybenzoic Acid

1987 ◽  
Vol 19 (2) ◽  
pp. 120-128 ◽  
Author(s):  
George E. Marak, Jr. ◽  
Narsing A. Rao ◽  
Alex Sevanian ◽  
Vera Zdravkovich ◽  
Gerd O. Till ◽  
...  
Keyword(s):  
Sodium Benzoate ◽  
Dihydroxybenzoic Acid

Rietveld refinement of the cocrystal 2,4-dihydroxybenzoic acid–N′-(propan-2-ylidene)nicotinohydrazide (1/1)

2012 ◽  
Vol 68 (9) ◽  
pp. o335-o337 ◽  
Author(s):  
Saul H. Lapidus ◽  
Andreas Lemmerer ◽  
Joel Bernstein ◽  
Peter W. Stephens
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonding ◽  
Powder Diffraction ◽  
Supramolecular Assembly ◽  
Covalent Bond ◽  
Analytical Tool ◽  
Powder Diffraction Data ◽  
Dihydroxybenzoic Acid ◽  
Bond Forming ◽  
Hydrogen Bond Interactions

A further example of using a covalent-bond-forming reaction to alter supramolecular assembly by modification of hydrogen-bonding possibilities is presented. This concept was introduced by Lemmerer, Bernstein & Kahlenberg [CrystEngComm(2011),13, 55–59]. The title structure, C9H11N3O·C7H6O4, which consists of a reacted niazid molecule,viz.N′-(propan-2-ylidene)nicotinohydrazide, and 2,4-dihydroxybenzoic acid, was solved from powder diffraction data using simulated annealing. The results further demonstrate the relevance and utility of powder diffraction as an analytical tool in the study of cocrystals and their hydrogen-bond interactions.

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