Salt Induced Lamellar to Bicontinuous Cubic Phase Transitions in Cationic Nanoparticles

2012 ◽  
Vol 116 (11) ◽  
pp. 3551-3556 ◽  
Author(s):  
Benjamin W. Muir ◽  
Guoliang Zhen ◽  
Pathiraja Gunatillake ◽  
Patrick G. Hartley
Keyword(s):  
Phase Transitions ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Cationic Nanoparticles

scholarly journals Structural studies of the lamellar to bicontinuous gyroid cubic (QGII) phase transitions under limited hydration conditions

Soft Matter ◽  
2015 ◽  
Vol 11 (10) ◽  
pp. 1991-1997 ◽  
Author(s):  
T.-Y. Dora Tang ◽  
Nicholas J. Brooks ◽  
Oscar Ces ◽  
John M. Seddon ◽  
Richard H. Templer
Keyword(s):  
Phase Transition ◽  
Phase Transitions ◽  
Elastic Energy ◽  
Cubic Phase ◽  
Structural Studies ◽  
Present Evidence ◽  
Bicontinuous Cubic

We present evidence for a non-diffracting structural intermediate during the lamellar to inverse bicontinuous cubic phase transition and show that elastic energy drives the cubic phase to equilibrium.

scholarly journals Novel Insights into the Mechanistic Routes of Lyotropic Phase Transitions

2014 ◽  
Vol 70 (a1) ◽  
pp. C1187-C1187
Author(s):  
Oscar Ces ◽  
John Seddon ◽  
Robert Law ◽  
Nicholas Brooks ◽  
Richard Templer
Keyword(s):  
Phase Transitions ◽  
High Speed ◽  
Liquid Crystalline ◽  
Equilibrium Phase ◽  
Model Membrane ◽  
Phase Behaviour ◽  
Cubic Phase ◽  
Pressure Jump ◽  
Bicontinuous Cubic

When mixed with water, biological amphiphiles such as phospholipids can self-assemble to form a variety of lyotropic liquid crystalline structures including 1-D flat lamellar bilayers, 2-D hexagonal phases and 3-D bicontinuous cubic structures1. The role of the lamellar phase in nature is well understood – flat bilayers maintain the fundamental integrity of all living cells. However, non-lamellar phases also play a vital role in vivo. Extended cubic phases have been directly observed in cells and in addition, the repeating pores which form the continuously accessible structure of these bicontinuous phases are very closely structurally related to membrane pores formed during membrane fusion and fission. The equilibrium phase behaviour of pure phospholipids in water and simple model membrane mixtures has been widely studied but their out of equilibrium behaviour remains poorly understood. We have addressed this knowledge gap through pioneering work looking at the kinetics of phase transitions in phospholipid/water systems and phospholipid/protein/water mixtures using the pressure jump relaxation technique in conjunction with high speed, time resolved small angle X-ray diffraction. This presentation will provide an overview of how our bottom-up approach using model membrane systems has enabled us to establish the mechanistic routes and intermediates in a number of phase transition schemes including bicontinuous cubic to lamellar, hexagonal to lamellar and inter-cubic phase transitions.

Triply-periodic nanostructures in surfactant, block copolymer, and biomembrane systems, and simulation of TEMs

1993 ◽  
Vol 51 ◽  
pp. 884-885
Author(s):  
David M. Anderson ◽  
Tomas Landh
Keyword(s):  
Liquid Crystalline ◽  
Diblock Copolymers ◽  
Cubic Phase ◽  
List Type ◽  
Interpenetrating Networks ◽  
Triply Periodic ◽  
Wide Range ◽  
Bicontinuous Cubic ◽  
Phase Liquid ◽  
Dividing Surface

First discovered in surfactant-water liquid crystalline systems, so-called ‘bicontinuous cubic phases’ have the property that hydropnilic and lipophilic microdomains form interpenetrating networks conforming to cubic lattices on the scale of nanometers. Later these same structures were found in star diblock copolymers, where the simultaneous continuity of elastomeric and glassy domains gives rise to unique physical properties. Today it is well-established that the symmetry and topology of such a morphology are accurately described by one of several triply-periodic minimal surfaces, and that the interface between hydrophilic and hydrophobic, or immiscible polymer, domains is described by a triply-periodic surface of constant, nonzero mean curvature. One example of such a dividing surface is shown in figure 5.The study of these structures has become of increasing importance in the past five years for two reasons:1)Bicontinuous cubic phase liquid crystals are now being polymerized to create microporous materials with monodispersed pores and readily functionalizable porewalls; figure 3 shows a TEM from a polymerized surfactant / methylmethacrylate / water cubic phase; and2)Compelling evidence has been found that these same morphologies describe biomembrane systems in a wide range of cells.

Effects of structural modification of (alkyldiene-imidazolium bromide)-based gemini monomers on the formation of the lyotropic bicontinuous cubic phase

Soft Matter ◽  
2021 ◽  
Author(s):  
Patrick Li ◽  
Maria I. Reinhardt ◽  
Samantha S. Dyer ◽  
Kara E. Moore ◽  
Omar Q. Imran ◽  
...  
Keyword(s):  
Structural Modification ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Phase Retention

Seven homologues of an amphiphilic gemini monomer were synthesized; and four of them (highlighted in red in the table) were found to form a bicontinuous cubic (Q) phase with glycerol or water and could be radically cross-linked with phase retention.

Predicting the release profile of small molecules from within the ordered nanostructured lipidic bicontinuous cubic phase using translational diffusion coefficients determined by PFG-NMR

Nanoscale ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 2471-2478 ◽  
Author(s):  
Thomas G. Meikle ◽  
Shenggen Yao ◽  
Alexandru Zabara ◽  
Charlotte E. Conn ◽  
Calum J. Drummond ◽  
...  
Keyword(s):  
Small Molecules ◽  
Diffusion Coefficients ◽  
Translational Diffusion ◽  
Release Profile ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Pfg Nmr

scholarly journals Exploring the structural relationship between encapsulated antimicrobial peptides and the bilayer membrane mimetic lipidic cubic phase: studies with gramicidin A′

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68685-68694 ◽  
Author(s):  
Thomas G. Meikle ◽  
Charlotte E. Conn ◽  
Frances Separovic ◽  
Calum J. Drummond
Keyword(s):  
Antimicrobial Peptides ◽  
Low Cost ◽  
Bilayer Membrane ◽  
Structural Relationship ◽  
Gramicidin A ◽  
Cubic Phase ◽  
Membrane Peptides ◽  
Membrane Mimetic ◽  
Lipidic Cubic Phase ◽  
Bicontinuous Cubic

Lipid based bicontinuous cubic mesophases provide a low-cost, robust membrane mimetic nanomaterial which allows for the incorporation of membrane peptides and proteins.

Kinetics of Lyotropic Phase Transitions Involving the Inverse Bicontinuous Cubic Phases

Langmuir ◽  
2000 ◽  
Vol 16 (8) ◽  
pp. 3578-3582 ◽  
Author(s):  
A. Squires ◽  
R. H. Templer ◽  
O. Ces ◽  
A. Gabke ◽  
J. Woenckhaus ◽  
...  
Keyword(s):  
Phase Transitions ◽  
Cubic Phases ◽  
Bicontinuous Cubic ◽  
Kinetics Of

scholarly journals Na+ and solute diffusion in aqueous channels of Myverol bicontinuous cubic phase: PGSE NMR and computer modelling

2016 ◽  
Vol 55 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Timothy J. Larkin ◽  
Christopher J. Garvey ◽  
Dmitry Shishmarev ◽  
Philip W. Kuchel ◽  
Konstantin I. Momot
Keyword(s):  
Computer Modelling ◽  
Solute Diffusion ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Pgse Nmr
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