Predicting the release profile of small molecules from within the ordered nanostructured lipidic bicontinuous cubic phase using translational diffusion coefficients determined by PFG-NMR

Nanoscale ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 2471-2478 ◽  
Author(s):  
Thomas G. Meikle ◽  
Shenggen Yao ◽  
Alexandru Zabara ◽  
Charlotte E. Conn ◽  
Calum J. Drummond ◽  
...  
Keyword(s):  
Small Molecules ◽  
Diffusion Coefficients ◽  
Translational Diffusion ◽  
Release Profile ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Pfg Nmr

scholarly journals Measuring translational diffusion coefficients of peptides and proteins by PFG-NMR using band-selective RF pulses

2014 ◽  
Vol 43 (6-7) ◽  
pp. 331-339 ◽  
Author(s):  
Shenggen Yao ◽  
Daniel K. Weber ◽  
Frances Separovic ◽  
David W. Keizer
Keyword(s):  
Diffusion Coefficients ◽  
Translational Diffusion ◽  
Rf Pulses ◽  
Pfg Nmr

Ionotropically Gelled Bicontinuous Cubic Phase as a Matrix for Controlled Release

1993 ◽  
Vol 331 ◽  
Author(s):  
S. Puvvada ◽  
J. Naciri ◽  
B. R. Ratna
Keyword(s):  
Release Rate ◽  
Release Profile ◽  
Water Soluble ◽  
Cubic Phase ◽  
First Order ◽  
On Demand ◽  
Release Studies ◽  
Order Release ◽  
Bicontinuous Cubic ◽  
Soluble Polysaccharide

AbstractRelease studies from a lipid-based matrix, known as the bicontinuous cubic phase, are presented. This matrix consists of nano-sized pores within which various proteins and drugs can be dispersed and subsequently released to the exterior. To control the release rate, the aqueous pores of the cubic phase were gelled using sodium alginate, a water soluble polysaccharide. Studies show that the release rate is significantly lowered upon gelation and the first order release profile exhibited by the ungelled cubic phase is converted to a zeroorder linear profile. Further, it has been shown that the release trends can be reversed by degelation. This opens up the possibility of releasing large quantities of the protein when required (drugs on demand concept) by degelling the gelled samples.

Triply-periodic nanostructures in surfactant, block copolymer, and biomembrane systems, and simulation of TEMs

1993 ◽  
Vol 51 ◽  
pp. 884-885
Author(s):  
David M. Anderson ◽  
Tomas Landh
Keyword(s):  
Liquid Crystalline ◽  
Diblock Copolymers ◽  
Cubic Phase ◽  
List Type ◽  
Interpenetrating Networks ◽  
Triply Periodic ◽  
Wide Range ◽  
Bicontinuous Cubic ◽  
Phase Liquid ◽  
Dividing Surface

First discovered in surfactant-water liquid crystalline systems, so-called ‘bicontinuous cubic phases’ have the property that hydropnilic and lipophilic microdomains form interpenetrating networks conforming to cubic lattices on the scale of nanometers. Later these same structures were found in star diblock copolymers, where the simultaneous continuity of elastomeric and glassy domains gives rise to unique physical properties. Today it is well-established that the symmetry and topology of such a morphology are accurately described by one of several triply-periodic minimal surfaces, and that the interface between hydrophilic and hydrophobic, or immiscible polymer, domains is described by a triply-periodic surface of constant, nonzero mean curvature. One example of such a dividing surface is shown in figure 5.The study of these structures has become of increasing importance in the past five years for two reasons:1)Bicontinuous cubic phase liquid crystals are now being polymerized to create microporous materials with monodispersed pores and readily functionalizable porewalls; figure 3 shows a TEM from a polymerized surfactant / methylmethacrylate / water cubic phase; and2)Compelling evidence has been found that these same morphologies describe biomembrane systems in a wide range of cells.

Effects of structural modification of (alkyldiene-imidazolium bromide)-based gemini monomers on the formation of the lyotropic bicontinuous cubic phase

Soft Matter ◽  
2021 ◽  
Author(s):  
Patrick Li ◽  
Maria I. Reinhardt ◽  
Samantha S. Dyer ◽  
Kara E. Moore ◽  
Omar Q. Imran ◽  
...  
Keyword(s):  
Structural Modification ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Phase Retention

Seven homologues of an amphiphilic gemini monomer were synthesized; and four of them (highlighted in red in the table) were found to form a bicontinuous cubic (Q) phase with glycerol or water and could be radically cross-linked with phase retention.

scholarly journals Ion Transport Properties and Ionicity of 1,3-Dimethyl-1,2,3-Triazolium Salts with Fluorinated Anions

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1723 ◽  
Author(s):  
Martin Pulst ◽  
Yury Golitsyn ◽  
Detlef Reichert ◽  
Jörg Kressler
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Diffusion Coefficients ◽  
Important Class ◽  
Spectroscopy Data ◽  
Ion Conductivities ◽  
Electrochemical Devices ◽  
Pfg Nmr ◽  
Conductive Properties ◽  
Triazolium Salts

1,2,3-Triazolium salts are an important class of materials with a plethora of sophisticated applications. A series of three novel 1,3-dimethyl-1,2,3-triazolium salts with fluorine, containing anions of various size, is synthesized by methylation of 1,2,3-triazole. Their ion conductivity is measured by impedance spectroscopy, and the corresponding ionicities are determined by diffusion coefficients obtained from 1H and 19F pulsed field gradient nuclear magnetic resonance (PFG NMR) spectroscopy data, revealing that the anion strongly influences their ion conductive properties. Since the molar ion conductivities and ionicities of the 1,3-dimethyl-1,2,3-triazolium salts are enhanced in comparison to other 1,2,3-triazolium salts with longer alkyl substituents, they are promising candidates for applications as electrolytes in electrochemical devices.

scholarly journals Exploring the structural relationship between encapsulated antimicrobial peptides and the bilayer membrane mimetic lipidic cubic phase: studies with gramicidin A′

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68685-68694 ◽  
Author(s):  
Thomas G. Meikle ◽  
Charlotte E. Conn ◽  
Frances Separovic ◽  
Calum J. Drummond
Keyword(s):  
Antimicrobial Peptides ◽  
Low Cost ◽  
Bilayer Membrane ◽  
Structural Relationship ◽  
Gramicidin A ◽  
Cubic Phase ◽  
Membrane Peptides ◽  
Membrane Mimetic ◽  
Lipidic Cubic Phase ◽  
Bicontinuous Cubic

Lipid based bicontinuous cubic mesophases provide a low-cost, robust membrane mimetic nanomaterial which allows for the incorporation of membrane peptides and proteins.

scholarly journals Na+ and solute diffusion in aqueous channels of Myverol bicontinuous cubic phase: PGSE NMR and computer modelling

2016 ◽  
Vol 55 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Timothy J. Larkin ◽  
Christopher J. Garvey ◽  
Dmitry Shishmarev ◽  
Philip W. Kuchel ◽  
Konstantin I. Momot
Keyword(s):  
Computer Modelling ◽  
Solute Diffusion ◽  
Cubic Phase ◽  
Bicontinuous Cubic ◽  
Pgse Nmr

The Effect of Shape and Concentration on Translational Diffusion of Proteins Measured by PFG NMR

2017 ◽  
Vol 49 (1) ◽  
pp. 35-51 ◽  
Author(s):  
A. M. Kusova ◽  
A. E. Sitnitsky ◽  
B. Z. Idiyatullin ◽  
D. R. Bakirova ◽  
Yu. F. Zuev
Keyword(s):  
Translational Diffusion ◽  
Pfg Nmr
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