Cyclodextrin-Scaffolded Alamethicin with Remarkably Efficient Membrane Permeabilizing Properties and Membrane Current Conductance

2012 ◽  
Vol 116 (26) ◽  
pp. 7652-7659 ◽  
Author(s):  
Claudia U. Hjørringgaard ◽  
Brian S. Vad ◽  
Vladimir V. Matchkov ◽  
Søren B. Nielsen ◽  
Thomas Vosegaard ◽  
...  
Keyword(s):  
Membrane Current ◽  
Current Conductance

Membrane Current of Crab Muscle

Nature ◽  
1963 ◽  
Vol 198 (4878) ◽  
pp. 393-394 ◽  
Author(s):  
ALFRED STRICKHOLM
Keyword(s):  
Membrane Current

The membrane current of single rod outer segments

1979 ◽  
Vol 19 (4) ◽  
pp. 385 ◽  
Author(s):  
T.D. Lamb ◽  
D.A. Baylor ◽  
K.-W. Yau
Keyword(s):  
Membrane Current ◽  
Rod Outer Segments ◽  
Outer Segments

Ca2+ signalling and membrane current activated by cADPr in starfish oocytes

2003 ◽  
Vol 446 (5) ◽  
pp. 541-552 ◽  
Author(s):  
F. Moccia ◽  
G. A. Nusco ◽  
D. Lim ◽  
E. Ercolano ◽  
G. Gragnaniello ◽  
...  
Keyword(s):  
Membrane Current

Reduction of voltage-activated K+ currents by forskolin is not mediated via cAMP in pleural sensory neurons of Aplysia

1990 ◽  
Vol 64 (5) ◽  
pp. 1474-1483 ◽  
Author(s):  
D. A. Baxter ◽  
J. H. Byrne
Keyword(s):  
Adenylate Cyclase ◽  
Sensory Neurons ◽  
Water Solubility ◽  
Membrane Current ◽  
Peak Amplitude ◽  
Bath Application ◽  
Voltage Dependent ◽  
K Current ◽  
Derivatives Of ◽  
K Currents

1. Forskolin is often used to activate adenylate cyclase in studies relating adenosine 3',5'-cyclic monophosphate (cAMP) to the modulation of membrane current. There is growing concern, however, that some actions of forskolin are independent of cAMP. With the use of two-electrode voltage-clamp techniques, we compared the effects of analogues of cAMP to the effects of forskolin on K+ currents in somata of sensory neurons that were isolated from pleural ganglia of Aplysia californica. 2. Analogues of cAMP did not reduce the peak amplitude of either the transient K+ current (IA) or the voltage-dependent K+ current (IK.V). Analogues of cAMP did reduce the previously described cAMP-sensitive S K+ current (IK.S). In contrast, forskolin reduced the peak amplitude of both IA and IK.V. Furthermore, both IA and IK.V were reduced by 1,9-dideoxy-forskolin, a derivative of forskolin that does not activate adenylate cyclase. These results indicate that the effects of forskolin and 1,9-dideoxy-forskolin on IA and IK.V were not mediated via cAMP. 3. Bath application of a modified form of forskolin (7-deacetyl-6-[N-acetylglycyl]-forskolin), which has enhanced water solubility and activates adenylate cyclase, reduced IK.S, but did not alter either IA or IK.V. Thus it appears that certain derivatives of forskolin can be used to activate adenylate cyclase and avoid some of the nonspecific actions on membrane current that are associated with forskolin.

scholarly journals The Effects of Fungi on the Direct Current Conductance of Electrical Insulating Materials

1955 ◽  
Vol 3 (2) ◽  
pp. 75-81
Author(s):  
Leonard Teitell ◽  
Sigmund Berk ◽  
Annette Kravitz
Keyword(s):  
Direct Current ◽  
Insulating Materials ◽  
Current Conductance

scholarly journals A novel mutual information estimator to measure spike train correlations in a model thalamocortical network

2018 ◽  
Vol 120 (6) ◽  
pp. 2730-2744 ◽  
Author(s):  
Ekaterina D. Gribkova ◽  
Baher A. Ibrahim ◽  
Daniel A. Llano
Keyword(s):  
Mutual Information ◽  
Information Transmission ◽  
Spike Train ◽  
Calcium Current ◽  
Thalamic Reticular Nucleus ◽  
Reticular Nucleus ◽  
Sensory Signals ◽  
Layer 4 ◽  
The Impact ◽  
Current Conductance

The impact of thalamic state on information transmission to the cortex remains poorly understood. This limitation exists due to the rich dynamics displayed by thalamocortical networks and because of inadequate tools to characterize those dynamics. Here, we introduce a novel estimator of mutual information and use it to determine the impact of a computational model of thalamic state on information transmission. Using several criteria, this novel estimator, which uses an adaptive partition, is shown to be superior to other mutual information estimators with uniform partitions when used to analyze simulated spike train data with different mean spike rates, as well as electrophysiological data from simultaneously recorded neurons. When applied to a thalamocortical model, the estimator revealed that thalamocortical cell T-type calcium current conductance influences mutual information between the input and output from this network. In particular, a T-type calcium current conductance of ~40 nS appears to produce maximal mutual information between the input to this network (conceptualized as afferent input to the thalamocortical cell) and the output of the network at the level of a layer 4 cortical neuron. Furthermore, at particular combinations of inputs to thalamocortical and thalamic reticular nucleus cells, thalamic cell bursting correlated strongly with recovery of mutual information between thalamic afferents and layer 4 neurons. These studies suggest that the novel mutual information estimator has advantages over previous estimators and that thalamic reticular nucleus activity can enhance mutual information between thalamic afferents and thalamorecipient cells in the cortex. NEW & NOTEWORTHY In this study, a novel mutual information estimator was developed to analyze information flow in a model thalamocortical network. Our findings suggest that this estimator is a suitable tool for signal transmission analysis, particularly in neural circuits with disparate firing rates, and that the thalamic reticular nucleus can potentiate ascending sensory signals, while thalamic recipient cells in the cortex can recover mutual information in ascending sensory signals that is lost due to thalamic bursting.

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