Membrane Current of Crab Muscle

Nature ◽  
1963 ◽  
Vol 198 (4878) ◽  
pp. 393-394 ◽  
Author(s):  
ALFRED STRICKHOLM
Keyword(s):  
Membrane Current

The membrane current of single rod outer segments

1979 ◽  
Vol 19 (4) ◽  
pp. 385 ◽  
Author(s):  
T.D. Lamb ◽  
D.A. Baylor ◽  
K.-W. Yau
Keyword(s):  
Membrane Current ◽  
Rod Outer Segments ◽  
Outer Segments

Ca2+ signalling and membrane current activated by cADPr in starfish oocytes

2003 ◽  
Vol 446 (5) ◽  
pp. 541-552 ◽  
Author(s):  
F. Moccia ◽  
G. A. Nusco ◽  
D. Lim ◽  
E. Ercolano ◽  
G. Gragnaniello ◽  
...  
Keyword(s):  
Membrane Current

Reduction of voltage-activated K+ currents by forskolin is not mediated via cAMP in pleural sensory neurons of Aplysia

1990 ◽  
Vol 64 (5) ◽  
pp. 1474-1483 ◽  
Author(s):  
D. A. Baxter ◽  
J. H. Byrne
Keyword(s):  
Adenylate Cyclase ◽  
Sensory Neurons ◽  
Water Solubility ◽  
Membrane Current ◽  
Peak Amplitude ◽  
Bath Application ◽  
Voltage Dependent ◽  
K Current ◽  
Derivatives Of ◽  
K Currents

1. Forskolin is often used to activate adenylate cyclase in studies relating adenosine 3',5'-cyclic monophosphate (cAMP) to the modulation of membrane current. There is growing concern, however, that some actions of forskolin are independent of cAMP. With the use of two-electrode voltage-clamp techniques, we compared the effects of analogues of cAMP to the effects of forskolin on K+ currents in somata of sensory neurons that were isolated from pleural ganglia of Aplysia californica. 2. Analogues of cAMP did not reduce the peak amplitude of either the transient K+ current (IA) or the voltage-dependent K+ current (IK.V). Analogues of cAMP did reduce the previously described cAMP-sensitive S K+ current (IK.S). In contrast, forskolin reduced the peak amplitude of both IA and IK.V. Furthermore, both IA and IK.V were reduced by 1,9-dideoxy-forskolin, a derivative of forskolin that does not activate adenylate cyclase. These results indicate that the effects of forskolin and 1,9-dideoxy-forskolin on IA and IK.V were not mediated via cAMP. 3. Bath application of a modified form of forskolin (7-deacetyl-6-[N-acetylglycyl]-forskolin), which has enhanced water solubility and activates adenylate cyclase, reduced IK.S, but did not alter either IA or IK.V. Thus it appears that certain derivatives of forskolin can be used to activate adenylate cyclase and avoid some of the nonspecific actions on membrane current that are associated with forskolin.

Anatomy and physiology of the sinus node

ESC CardioMed ◽  
2018 ◽  
pp. 1940-1943
Author(s):  
Antonio Zaza
Keyword(s):  
Electrical Activity ◽  
Temporal Variability ◽  
Sinoatrial Node ◽  
Sinus Node ◽  
Membrane Current ◽  
Membrane Channels ◽  
Autonomic Balance ◽  
Electrical Excitation ◽  
Anatomy And Physiology ◽  
Mammalian Heart

The sinoatrial node (SAN) is the dominant pacemaker structure in the mammalian heart. It is endowed with robust intrinsic automaticity, providing periodic electrical excitation with a cycle widely modulated by autonomic influences. A number of membrane channels and transporters contribute to the net membrane current supporting SAN electrical activity, whose periodicity is determined by the interplay of two oscillators termed ‘membrane’ and ‘calcium’ clock respectively. This chapter describes the structure of the SAN, the peculiarities of its electrical cycle, the nature and modulation of the underlying clocks, and SAN interaction with atrial muscle. Moreover, the features and determinants of the temporal variability of the pacemaker cycle, clinically used to assess autonomic balance, are briefly discussed.

Sign in / Sign up

Export Citation Format

Share Document