scholarly journals Molecular Interactions between Cell Penetrating Peptide Pep-1 and Model Cell Membranes

2012 ◽  
Vol 116 (8) ◽  
pp. 2545-2552 ◽  
Author(s):  
Bei Ding ◽  
Zhan Chen
Keyword(s):  
Molecular Interactions ◽  
Cell Membranes ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Model Cell

Elucidation of molecular interactions between lipid membranes and ionic liquids using model cell membranes

Soft Matter ◽  
2012 ◽  
Vol 8 (20) ◽  
pp. 5501 ◽  
Author(s):  
Seunghwan Jeong ◽  
Sung Ho Ha ◽  
Sang-Hyun Han ◽  
Min-Cheol Lim ◽  
Sun Min Kim ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Molecular Interactions ◽  
Lipid Membranes ◽  
Cell Membranes ◽  
Model Cell

Molecular Interactions Between Silver Nanoparticles and Model Cell Membranes

2018 ◽  
Vol 61 (9-11) ◽  
pp. 1148-1162 ◽  
Author(s):  
Peipei Hu ◽  
Xiaoxian Zhang ◽  
Yaoxin Li ◽  
Cayla Pichan ◽  
Zhan Chen
Keyword(s):  
Silver Nanoparticles ◽  
Molecular Interactions ◽  
Cell Membranes ◽  
Model Cell

Molecular Interactions between Amantadine and Model Cell Membranes

Langmuir ◽  
2014 ◽  
Vol 30 (28) ◽  
pp. 8491-8499 ◽  
Author(s):  
Fu-Gen Wu ◽  
Pei Yang ◽  
Chi Zhang ◽  
Bolin Li ◽  
Xiaofeng Han ◽  
...  
Keyword(s):  
Molecular Interactions ◽  
Cell Membranes ◽  
Model Cell

Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes

2012 ◽  
Vol 81 (1) ◽  
pp. 64-73 ◽  
Author(s):  
Shinji Sakuma ◽  
Masaya Suita ◽  
Takafumi Yamamoto ◽  
Yoshie Masaoka ◽  
Makoto Kataoka ◽  
...  
Keyword(s):  
Cell Membranes ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals On the mechanisms of the internalization of S413-PV cell-penetrating peptide

2005 ◽  
Vol 390 (2) ◽  
pp. 603-612 ◽  
Author(s):  
Miguel Mano ◽  
Cristina Teodósio ◽  
Artur Paiva ◽  
Sérgio Simões ◽  
Maria C. Pedroso de Lima
Keyword(s):  
Cellular Uptake ◽  
Cell Membranes ◽  
Heparan Sulphate ◽  
Cell Penetrating Peptides ◽  
Membrane Receptors ◽  
Live Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Pv Cell

Cell-penetrating peptides have been shown to translocate across eukaryotic cell membranes through a temperature-insensitive and energy-independent mechanism that does not involve membrane receptors or transporters. Although cell-penetrating peptides have been successfully used to mediate the intracellular delivery of a wide variety of molecules of pharmacological interest both in vitro and in vivo, the mechanisms by which cellular uptake occurs remain unclear. In the face of recent reports demonstrating that uptake of cell-penetrating peptides occurs through previously described endocytic pathways, or is a consequence of fixation artifacts, we conducted a critical re-evaluation of the mechanism responsible for the cellular uptake of the S413-PV karyophilic cell-penetrating peptide. We report that the S413-PV peptide is able to accumulate inside live cells very efficiently through a rapid, dose-dependent and non-toxic process, providing clear evidence that the cellular uptake of this peptide cannot be attributed to fixation artifacts. Comparative analysis of peptide uptake into mutant cells lacking heparan sulphate proteoglycans demonstrates that their presence at the cell surface facilitates the cellular uptake of the S413-PV peptide, particularly at low peptide concentrations. Most importantly, our results clearly demonstrate that, in addition to endocytosis, which is only evident at low peptide concentrations, the efficient cellular uptake of the S413-PV cell-penetrating peptide occurs mainly through an alternative, non-endocytic mechanism, most likely involving direct penetration across cell membranes.

scholarly journals Vesicles mimicking normal and cancer cell membranes exhibit differential responses to the cell-penetrating peptide Pep-1

2018 ◽  
Vol 1860 (6) ◽  
pp. 1394-1402 ◽  
Author(s):  
Bashiyar Almarwani ◽  
Esther Nzuzi Phambu ◽  
Christopher Alexander ◽  
Ha Aimee T. Nguyen ◽  
Nsoki Phambu ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Differential Responses

Molecular interactions between gold nanoparticles and model cell membranes

2015 ◽  
Vol 17 (15) ◽  
pp. 9873-9884 ◽  
Author(s):  
Peipei Hu ◽  
Xiaoxian Zhang ◽  
Chi Zhang ◽  
Zhan Chen
Keyword(s):  
Gold Nanoparticles ◽  
Cell Membrane ◽  
Mammalian Cell ◽  
Molecular Interactions ◽  
Cell Membranes ◽  
Membrane Interactions ◽  
Flip Flop ◽  
Direct Observations ◽  
Model Cell

Direct observations of the lipid flip-flop induced by Au NP – model mammalian cell membrane interactions.

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