Consensus 3D Model of μ-Opioid Receptor Ligand Efficacy Based on a Quantitative Conformationally Sampled Pharmacophore

Jihyun Shim; Andrew Coop; Alexander D. MacKerell

doi:10.1021/jp202542g

Consensus 3D Model of μ-Opioid Receptor Ligand Efficacy Based on a Quantitative Conformationally Sampled Pharmacophore

The Journal of Physical Chemistry B ◽

10.1021/jp202542g ◽

2011 ◽

Vol 115 (22) ◽

pp. 7487-7496 ◽

Cited By ~ 16

Author(s):

Jihyun Shim ◽

Andrew Coop ◽

Alexander D. MacKerell

Keyword(s):

Opioid Receptor ◽

3D Model ◽

Receptor Ligand ◽

Μ Opioid Receptor ◽

Conformationally Sampled Pharmacophore

Download Full-text

Densitometrical analysis of opioid receptor ligand binding in the human striatum—I. Distribution of μ opioid receptor defines shell and core of the ventral striatum

Neuroscience ◽

10.1016/0306-4522(96)00271-0 ◽

1996 ◽

Vol 75 (3) ◽

pp. 777-792 ◽

Cited By ~ 49

Author(s):

P. Voorn ◽

L.S. Brady ◽

H.W. Berendse ◽

E.K. Richfield

Keyword(s):

Ligand Binding ◽

Opioid Receptor ◽

Ventral Striatum ◽

Receptor Ligand ◽

Μ Opioid Receptor

Download Full-text

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Journal of Medicinal Chemistry ◽

10.1021/jm4010829 ◽

2013 ◽

Vol 56 (20) ◽

pp. 8019-8031 ◽

Cited By ~ 98

Author(s):

Xiao-Tao Chen ◽

Philip Pitis ◽

Guodong Liu ◽

Catherine Yuan ◽

Dimitar Gotchev ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Severe Pain ◽

Receptor Ligand ◽

Structure Activity Relationships ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Ethyl Amine

Download Full-text

Identification of an Efficacy Pharmacophore for μ Opioid Receptor Ligands Using the Conformationally Sampled Pharmacophore (CSP) Method

Biophysical Journal ◽

10.1016/j.bpj.2010.12.3198 ◽

2011 ◽

Vol 100 (3) ◽

pp. 549a

Author(s):

Jihyun Shim ◽

Andrew Coop ◽

Alexander D. MacKerell

Keyword(s):

Opioid Receptor ◽

Receptor Ligands ◽

Opioid Receptor Ligands ◽

Μ Opioid Receptor ◽

Conformationally Sampled Pharmacophore

Download Full-text

Synthesis and receptor binding properties of chimeric peptides containing a μ-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-amide

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.06.060 ◽

2006 ◽

Vol 16 (18) ◽

pp. 4839-4841 ◽

Cited By ~ 9

Author(s):

Susumu Kawano ◽

Akihiro Ambo ◽

Yusuke Sasaki

Keyword(s):

Opioid Receptor ◽

Receptor Binding ◽

Orphanin Fq ◽

Binding Properties ◽

Receptor Ligand ◽

Μ Opioid Receptor ◽

Chimeric Peptides

Download Full-text

Faculty Opinions recommendation of Inhibition of opioid transmission at the μ-opioid receptor prevents both food seeking and binge-like eating.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717956464.793467820 ◽

2012 ◽

Author(s):

Celeste Napier ◽

Amanda Persons

Keyword(s):

Opioid Receptor ◽

Μ Opioid Receptor ◽

Food Seeking

Download Full-text

Faculty Opinions recommendation of μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725638342.793526849 ◽

2017 ◽

Author(s):

Mathias Dutschmann

Keyword(s):

Opioid Receptor ◽

Receptor Activation ◽

Μ Opioid Receptor

Download Full-text

Faculty Opinions recommendation of T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726818325.793527236 ◽

2017 ◽

Author(s):

Gavril Pasternak

Keyword(s):

Opioid Receptor ◽

Opioid Tolerance ◽

Self Administration ◽

Μ Opioid Receptor

Download Full-text

FUNCTIONAL INTERACTIONS OF PERTUSSIS TOXIN-SENSITIVE G-PROTEINS WITH THE TRANSFECTED μ-OPIOID RECEPTOR IN RAT 1 FIBROBLASTS

Analgesia ◽

10.3727/107156995819562871 ◽

1995 ◽

Vol 1 (4) ◽

pp. 438-441

Author(s):

Zafiroula Georgoussi ◽

Ian Mullaney ◽

Alan Wise ◽

Craig Carr ◽

Graeme Milligan

Keyword(s):

G Proteins ◽

Opioid Receptor ◽

Pertussis Toxin ◽

Functional Interactions ◽

Μ Opioid Receptor

Download Full-text

A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects

Neuropharmacology ◽

10.1016/j.neuropharm.2021.108673 ◽

2021 ◽

pp. 108673

Author(s):

Kerri D. Pryce ◽

Hye Jin Kang ◽

Farhana Sakloth ◽

Yongfeng Liu ◽

Susan Khan ◽

...

Keyword(s):

Adverse Effects ◽

Opioid Receptor ◽

Allosteric Modulators ◽

Μ Opioid Receptor ◽

Positive Allosteric Modulators

Download Full-text

Modulation of μ-opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase γ

Neuroscience ◽

10.1016/j.neuroscience.2010.04.068 ◽

2010 ◽

Vol 169 (1) ◽

pp. 449-454 ◽

Cited By ~ 15

Author(s):

C. König ◽

O. Gavrilova-Ruch ◽

G. Segond von Banchet ◽

R. Bauer ◽

M. Grün ◽

...

Keyword(s):

Opioid Receptor ◽

Sensory Neurons ◽

Receptor Desensitization ◽

Peripheral Sensory Neurons ◽

Μ Opioid Receptor ◽

Phosphoinositide 3 Kinase ◽

Peripheral Sensory

Download Full-text