Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzyme Structure:  Probed by Surface-Enhanced Raman Spectroscopy

2007 ◽  
Vol 111 (17) ◽  
pp. 4527-4534 ◽  
Author(s):  
K. Mantelingu ◽  
A. Hari Kishore ◽  
K. Balasubramanyam ◽  
G. V. Pavan Kumar ◽  
M. Altaf ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Small Molecules ◽  
Histone Acetyltransferase ◽  
Surface Enhanced Raman Spectroscopy ◽  
Enzyme Structure ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Gold nanosponges (AuNS): a versatile nanostructure for surface-enhanced Raman spectroscopic detection of small molecules and biomolecules

The Analyst ◽  
2015 ◽  
Vol 140 (21) ◽  
pp. 7278-7282 ◽  
Author(s):  
Gregory Q. Wallace ◽  
Mariachiara S. Zuin ◽  
Mohammadali Tabatabaei ◽  
Pierangelo Gobbo ◽  
François Lagugné-Labarthet ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Small Molecules ◽  
Surface Enhanced Raman Spectroscopy ◽  
Raman Spectroscopic ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Prepared by simple pour and mix chemistry, gold nanosponges (AuNS) are versatile structures for surface-enhanced Raman spectroscopy (SERS).

Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3630-3635 ◽  
Author(s):  
Anh Nguyen ◽  
Zachary D. Schultz
Keyword(s):  
Raman Spectroscopy ◽  
Liquid Chromatography ◽  
Small Molecules ◽  
Surface Enhanced Raman Spectroscopy ◽  
Online Detection ◽  
Sheath Flow ◽  
Flow Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Detection And Quantification

Sheath-flow surface-enhanced Raman spectroscopy (SERS) was used for online detection and quantification of small molecules separated by liquid chromatography.

Bacterial detection and differentiation via direct volatile organic compound sensing with surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Infections ◽  
Direct Detection ◽  
Point Of Care ◽  
Surface Enhanced Raman Spectroscopy ◽  
E Coli ◽  
Recent Emergence ◽  
Surface Enhanced ◽  
Volatile Organic ◽  
Surface Enhanced Raman

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.

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