scholarly journals Conserved Patterns in Backbone Torsional Changes Allow for Single Base Flipping from Duplex DNA with Minimal Distortion of the Double Helix

2006 ◽  
Vol 110 (22) ◽  
pp. 10997-11004 ◽  
Author(s):  
Nilesh K. Banavali ◽  
Niu Huang ◽  
Alexander D. MacKerell
Keyword(s):  
Double Helix ◽  
Duplex Dna ◽  
Base Flipping ◽  
Single Base ◽  
Minimal Distortion

Rapid Alkene–Alkene Photo-Cross-Linking on the Base-Flipping-Out Field in Duplex DNA

2022 ◽  
Author(s):  
Ahmed Mostafa Abdelhady ◽  
Kazumitsu Onizuka ◽  
Kei Ishida ◽  
Sayaka Yajima ◽  
Eriko Mano ◽  
...  
Keyword(s):  
Cross Linking ◽  
Duplex Dna ◽  
Base Flipping

Identification of Single-Base Mismatches in Duplex DNA by EPR Spectroscopy

2009 ◽  
Vol 131 (50) ◽  
pp. 18054-18056 ◽  
Author(s):  
Pavol Cekan ◽  
Snorri Th. Sigurdsson
Keyword(s):  
Epr Spectroscopy ◽  
Duplex Dna ◽  
Single Base

scholarly journals Reversed-phase ion-pair liquid chromatography method for purification of duplex DNA with single base pair resolution

2013 ◽  
Vol 41 (20) ◽  
pp. e194-e194 ◽  
Author(s):  
Christina L. Wysoczynski ◽  
Sarah C. Roemer ◽  
Vishantie Dostal ◽  
Robert M. Barkley ◽  
Mair E. A. Churchill ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Base Pair ◽  
Reversed Phase ◽  
Ion Pair ◽  
Duplex Dna ◽  
Chromatography Method ◽  
Single Base ◽  
Single Base Pair ◽  
Liquid Chromatography Method

scholarly journals An overview of recent advances in duplex DNA recognition by small molecules

2018 ◽  
Vol 14 ◽  
pp. 1051-1086 ◽  
Author(s):  
Sayantan Bhaduri ◽  
Nihar Ranjan ◽  
Dev P Arya
Keyword(s):  
Small Molecules ◽  
Double Helix ◽  
Dna Recognition ◽  
Duplex Dna ◽  
Synthetic Dna ◽  
Natural Ligands ◽  
Dna Protein Interaction ◽  
Dna Binders ◽  
Dna Double Helix ◽  
A Site

As the carrier of genetic information, the DNA double helix interacts with many natural ligands during the cell cycle, and is amenable to such intervention in diseases such as cancer biogenesis. Proteins bind DNA in a site-specific manner, not only distinguishing between the geometry of the major and minor grooves, but also by making close contacts with individual bases within the local helix architecture. Over the last four decades, much research has been reported on the development of small non-natural ligands as therapeutics to either block, or in some cases, mimic a DNA–protein interaction of interest. This review presents the latest findings in the pursuit of novel synthetic DNA binders. This article provides recent coverage of major strategies (such as groove recognition, intercalation and cross-linking) adopted in the duplex DNA recognition by small molecules, with an emphasis on major works of the past few years.

Base Flipping of the Thymine Dimer in Duplex DNA§

2007 ◽  
Vol 111 (40) ◽  
pp. 11843-11849 ◽  
Author(s):  
Lauren L. O'Neil ◽  
Alan Grossfield ◽  
Olaf Wiest
Keyword(s):  
Duplex Dna ◽  
Base Flipping ◽  
Thymine Dimer
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