Transition-State Mimetics for HIV Protease Inhibitors:  Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester-Derived Titanium Enolate Syn and Anti-Aldol Reactions

1998 ◽  
Vol 63 (18) ◽  
pp. 6146-6152 ◽  
Author(s):  
Arun K. Ghosh ◽  
Steve Fidanze
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Aldol Reactions ◽  
Hiv Protease Inhibitors ◽  
Stereocontrolled Synthesis ◽  
Hydroxyethylamine Isosteres

Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors

1992 ◽  
Vol 57 (21) ◽  
pp. 5692-5700 ◽  
Author(s):  
Dale J. Kempf ◽  
Thomas J. Sowin ◽  
Elizabeth M. Doherty ◽  
Steven M. Hannick ◽  
LynnMarie Codavoci ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Stereocontrolled Synthesis

Design of HIV protease inhibitors with effective antiviral activity: Use of allophenylnorstatine as a transition-state mimic

Peptides 1992 ◽  
1993 ◽  
pp. 805-807
Author(s):  
Yoshiaki Kiso ◽  
Tsutomu Mimoto ◽  
Junya Imai ◽  
Sumitsugu Kisanuki ◽  
Naoko Hattori ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Transition State ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors
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