Synthesis, Conformational Analysis and Biological Studies of Cyclic Cationic Antimicrobial Peptides Containing Sugar Amino Acids

2008 ◽  
Vol 73 (22) ◽  
pp. 8731-8744 ◽  
Author(s):  
Tushar Kanti Chakraborty ◽  
Dipankar Koley ◽  
Rapolu Ravi ◽  
Viswanatha Krishnakumari ◽  
Ramakrishnan Nagaraj ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Conformational Analysis ◽  
Cationic Antimicrobial Peptides ◽  
Sugar Amino Acids ◽  
Biological Studies

scholarly journals Synthesis and Biological Studies of Dodecameric Cationic Antimicrobial Peptides Containing Tetrahydrofuran Amino Acids

ChemBioChem ◽  
2020 ◽  
Vol 21 (17) ◽  
pp. 2518-2526
Author(s):  
Uttam Ghosh ◽  
Isha Soni ◽  
Grace Kaul ◽  
Priyanka Trivedi ◽  
Vinita Chaturvedi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Cationic Antimicrobial Peptides ◽  
Biological Studies

scholarly journals Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs)

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Guang-Zong Tian ◽  
Jing Hu ◽  
Heng-Xi Zhang ◽  
Christoph Rademacher ◽  
Xiao-Peng Zou ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Sugar Amino Acids

ChemInform Abstract: Synthesis and Conformational Analysis of Cyclic Homooligomers from Pyranoid ε-Sugar Amino Acids.

ChemInform ◽  
2014 ◽  
Vol 45 (34) ◽  
pp. no-no
Author(s):  
Andres Feher-Voelger ◽  
Jorge Borges-Gonzalez ◽  
Romen Carrillo ◽  
Ezequiel Q. Morales ◽  
Javier Gonzalez-Platas ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Sugar Amino Acids

ChemInform Abstract: Synthesis and Conformational Analysis of Linear and Cyclic Peptides Containing Sugar Amino Acids.

ChemInform ◽  
2010 ◽  
Vol 28 (6) ◽  
pp. no-no
Author(s):  
E. VON ROEDERN ◽  
E. LOHOF ◽  
G. HESSLER ◽  
M. HOFFMANN ◽  
H. KESSLER
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Cyclic Peptides ◽  
Sugar Amino Acids

scholarly journals Targeting Mycobacterium tuberculosis and Other Microbial Pathogens Using Improved Synthetic Antibacterial Peptides

2013 ◽  
Vol 57 (5) ◽  
pp. 2295-2303 ◽  
Author(s):  
Santiago Ramón-García ◽  
Ralf Mikut ◽  
Carol Ng ◽  
Serge Ruden ◽  
Rudolf Volkmer ◽  
...  
Keyword(s):  
Amino Acids ◽  
Mycobacterium Tuberculosis ◽  
Antimicrobial Peptides ◽  
Fungal Pathogens ◽  
Antimicrobial Activities ◽  
Microbial Pathogens ◽  
Cationic Antimicrobial Peptides ◽  
Content Type ◽  
Activity Spectrum ◽  
Low Cytotoxicity

ABSTRACTThe lack of effective therapies for treating tuberculosis (TB) is a global health problem. WhileMycobacterium tuberculosisis notoriously resistant to most available antibiotics, we identified synthetic short cationic antimicrobial peptides that were active at low micromolar concentrations (less than 10 μM). These small peptides (averaging 10 amino acids) had remarkably broad spectra of antimicrobial activities against both bacterial and fungal pathogens and an indication of low cytotoxicity. In addition, their antimicrobial activities displayed various degrees of species specificity that were not related to taxonomy. For example,Candida albicansandStaphylococcus aureuswere the best surrogates to predict peptide activity againstM. tuberculosis, whileMycobacterium smegmatiswas a poor surrogate. Principle component analysis of activity spectrum profiles identified unique features associated with activity againstM. tuberculosisthat reflect their distinctive amino acid composition; active peptides were more hydrophobic and cationic, reflecting increased tryptophan with compensating decreases in valine and other uncharged amino acids and increased lysine. These studies provide foundations for development of cationic antimicrobial peptides as potential new therapeutic agents for TB treatment.

Synthesis and Conformational Analysis of Cyclic Homooligomers from Pyranoid ε-Sugar Amino Acids

2014 ◽  
Vol 20 (14) ◽  
pp. 4007-4022 ◽  
Author(s):  
Andrés Feher-Voelger ◽  
Jorge Borges-González ◽  
Romen Carrillo ◽  
Ezequiel Q. Morales ◽  
Javier González-Platas ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Sugar Amino Acids

Vibrational and electronic circular dichroism as powerful tools for the conformational analysis of cationic antimicrobial peptides

2016 ◽  
Vol 147 (8) ◽  
pp. 1439-1445 ◽  
Author(s):  
Lucie Kocourková ◽  
Pavlína Novotná ◽  
Lucie Šťovíčková-Habartová ◽  
Sabína Čujová ◽  
Václav Čeřovský ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Antimicrobial Peptides ◽  
Conformational Analysis ◽  
Electronic Circular Dichroism ◽  
Cationic Antimicrobial Peptides ◽  
Circular Dichroïsm

Synthesis of 3,4-di- O -acylated glucose-derived furanoid sugar amino acids (Gaa): conformational analysis of a Leu-enkephalin analog containing di- O -myristoylated Gaa

2004 ◽  
Vol 45 (29) ◽  
pp. 5623-5627 ◽  
Author(s):  
T.K. Chakraborty ◽  
B. Krishna Mohan ◽  
S. Uday Kumar ◽  
A. Prabhakar ◽  
B. Jagadeesh
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Sugar Amino Acids
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