scholarly journals Synthesis and Biological Studies of Dodecameric Cationic Antimicrobial Peptides Containing Tetrahydrofuran Amino Acids

ChemBioChem ◽  
2020 ◽  
Vol 21 (17) ◽  
pp. 2518-2526
Author(s):  
Uttam Ghosh ◽  
Isha Soni ◽  
Grace Kaul ◽  
Priyanka Trivedi ◽  
Vinita Chaturvedi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Cationic Antimicrobial Peptides ◽  
Biological Studies

Synthesis, Conformational Analysis and Biological Studies of Cyclic Cationic Antimicrobial Peptides Containing Sugar Amino Acids

2008 ◽  
Vol 73 (22) ◽  
pp. 8731-8744 ◽  
Author(s):  
Tushar Kanti Chakraborty ◽  
Dipankar Koley ◽  
Rapolu Ravi ◽  
Viswanatha Krishnakumari ◽  
Ramakrishnan Nagaraj ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Conformational Analysis ◽  
Cationic Antimicrobial Peptides ◽  
Sugar Amino Acids ◽  
Biological Studies

scholarly journals Targeting Mycobacterium tuberculosis and Other Microbial Pathogens Using Improved Synthetic Antibacterial Peptides

2013 ◽  
Vol 57 (5) ◽  
pp. 2295-2303 ◽  
Author(s):  
Santiago Ramón-García ◽  
Ralf Mikut ◽  
Carol Ng ◽  
Serge Ruden ◽  
Rudolf Volkmer ◽  
...  
Keyword(s):  
Amino Acids ◽  
Mycobacterium Tuberculosis ◽  
Antimicrobial Peptides ◽  
Fungal Pathogens ◽  
Antimicrobial Activities ◽  
Microbial Pathogens ◽  
Cationic Antimicrobial Peptides ◽  
Content Type ◽  
Activity Spectrum ◽  
Low Cytotoxicity

ABSTRACTThe lack of effective therapies for treating tuberculosis (TB) is a global health problem. WhileMycobacterium tuberculosisis notoriously resistant to most available antibiotics, we identified synthetic short cationic antimicrobial peptides that were active at low micromolar concentrations (less than 10 μM). These small peptides (averaging 10 amino acids) had remarkably broad spectra of antimicrobial activities against both bacterial and fungal pathogens and an indication of low cytotoxicity. In addition, their antimicrobial activities displayed various degrees of species specificity that were not related to taxonomy. For example,Candida albicansandStaphylococcus aureuswere the best surrogates to predict peptide activity againstM. tuberculosis, whileMycobacterium smegmatiswas a poor surrogate. Principle component analysis of activity spectrum profiles identified unique features associated with activity againstM. tuberculosisthat reflect their distinctive amino acid composition; active peptides were more hydrophobic and cationic, reflecting increased tryptophan with compensating decreases in valine and other uncharged amino acids and increased lysine. These studies provide foundations for development of cationic antimicrobial peptides as potential new therapeutic agents for TB treatment.

Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review

2019 ◽  
Vol 20 (9) ◽  
pp. 885-892
Author(s):  
Sara Silva ◽  
Nuno Vale
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Amino Acid ◽  
Antimicrobial Peptides ◽  
Resistance Mechanisms ◽  
Therapeutic Agents ◽  
Pharmacological Properties ◽  
Therapeutic Activity ◽  
Alternative Strategies ◽  
Cationic Antimicrobial Peptides ◽  
Specific Amino Acid

Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include coadministration with nanoparticles and/or classic drugs.

Membrane targeting cationic antimicrobial peptides

2019 ◽  
Vol 537 ◽  
pp. 163-185 ◽  
Author(s):  
Daniela Ciumac ◽  
Haoning Gong ◽  
Xuzhi Hu ◽  
Jian Ren Lu
Keyword(s):  
Antimicrobial Peptides ◽  
Membrane Targeting ◽  
Cationic Antimicrobial Peptides

Cationic Antimicrobial Peptides in Penaeid Shrimp

2011 ◽  
Vol 13 (4) ◽  
pp. 639-657 ◽  
Author(s):  
Anchalee Tassanakajon ◽  
Piti Amparyup ◽  
Kunlaya Somboonwiwat ◽  
Premruethai Supungul
Keyword(s):  
Antimicrobial Peptides ◽  
Penaeid Shrimp ◽  
Cationic Antimicrobial Peptides

scholarly journals Generation of novel cationic antimicrobial peptides from natural non-antimicrobial sequences by acid-amide substitution

2011 ◽  
Vol 10 (1) ◽  
pp. 11 ◽  
Author(s):  
Satoshi Ueno ◽  
Masaomi Minaba ◽  
Yuji Nishiuchi ◽  
Misako Taichi ◽  
Yasushi Tamada ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Acid Amide ◽  
Cationic Antimicrobial Peptides
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