Total Synthesis of (−)-Martinellic Acid via Radical Addition−Cyclization−Elimination Reaction

2008 ◽  
Vol 73 (12) ◽  
pp. 4464-4475 ◽  
Author(s):  
Atsushi Shirai ◽  
Okiko Miyata ◽  
Norimitsu Tohnai ◽  
Mikiji Miyata ◽  
David J. Procter ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Radical Addition ◽  
Elimination Reaction ◽  
Martinellic Acid

Heterocycle synthesis via radical reactions

2008 ◽  
Vol 80 (4) ◽  
pp. 717-726 ◽  
Author(s):  
Takeaki Naito
Keyword(s):  
Total Synthesis ◽  
Heterocyclic Compounds ◽  
Alkyl Radical ◽  
Radical Addition ◽  
Synthetic Method ◽  
Asymmetric Total Synthesis ◽  
Heterocycle Synthesis ◽  
Leaving Group ◽  
Martinellic Acid ◽  
Type Radical

A novel synthetic method for the preparation of nitrogen-containing heterocycles via the route involving domino-type radical addition/cyclization reaction of oxime ethers is described. Alkyl radical addition/cyclization of oxime ethers carrying an appropriate leaving group proceeded smoothly to form the alkylated nitrogen-containing heterocyclic compounds. Additionally, tin-mediated radical addition/cyclization/elimination (RACE) reaction of oxime ethers is newly found and successfully applied to an asymmetric total synthesis of (-)-martinellic acid.

An Improved Synthesis of (-)-Martinellic Acid via Radical Addition-Cyclization-Elimination Reaction of Chiral Oxime Ether

Synlett ◽  
2006 ◽  
Vol 2006 (06) ◽  
pp. 893-896 ◽  
Author(s):  
Takeaki Naito ◽  
Okiko Miyata ◽  
Atsushi Shirai ◽  
Shintaro Yoshino ◽  
Yoshifumi Takeda ◽  
...  
Keyword(s):  
Radical Addition ◽  
Elimination Reaction ◽  
Oxime Ether ◽  
Martinellic Acid

Formal Total Synthesis of (.+-.)-Martinellic Acid.

ChemInform ◽  
2005 ◽  
Vol 36 (25) ◽  
Author(s):  
Yong He ◽  
Remond Moningka ◽  
Carl J. Lovely
Keyword(s):  
Total Synthesis ◽  
Martinellic Acid

Asymmetric total synthesis of martinelline and martinellic acid

2007 ◽  
pp. 504-506 ◽  
Author(s):  
Shuhei Ikeda ◽  
Masatoshi Shibuya ◽  
Yoshiharu Iwabuchi
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Martinellic Acid

Development of radical addition–cyclization–elimination reaction of oxime ether and its application to formal synthesis of (±)-martinelline

Tetrahedron ◽  
2007 ◽  
Vol 63 (40) ◽  
pp. 10092-10117 ◽  
Author(s):  
Okiko Miyata ◽  
Atsushi Shirai ◽  
Shintaro Yoshino ◽  
Toshiki Nakabayashi ◽  
Yoshifumi Takeda ◽  
...  
Keyword(s):  
Radical Addition ◽  
Elimination Reaction ◽  
Oxime Ether ◽  
Formal Synthesis

Convergent Total Synthesis of Hikizimycin Enabled by Intermolecular Radical Addition to Aldehyde

2020 ◽  
Vol 142 (30) ◽  
pp. 13227-13234 ◽  
Author(s):  
Haruka Fujino ◽  
Takumi Fukuda ◽  
Masanori Nagatomo ◽  
Masayuki Inoue
Keyword(s):  
Total Synthesis ◽  
Radical Addition
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