Computational DFT Investigation of Vicinal Amide Group Anchimeric Assistance in Ether Cleavage

2008 ◽  
Vol 73 (6) ◽  
pp. 2066-2073 ◽  
Author(s):  
Matteo Calvaresi ◽  
Samuele Rinaldi ◽  
Antonio Arcelli ◽  
Marco Garavelli
Keyword(s):  
Amide Group ◽  
Ether Cleavage ◽  
Anchimeric Assistance

scholarly journals An acylation-Finkelstein approach to radioiodination of bioactives: The role of amide group anchimeric assistance

2018 ◽  
Vol 31 (7) ◽  
pp. e3835 ◽  
Author(s):  
Richard Fjellaksel ◽  
Damir Dugalic ◽  
Taye B. Demissie ◽  
Patrick J. Riss ◽  
Ole-Kristian Hjelstuen ◽  
...  
Keyword(s):  
Amide Group ◽  
Anchimeric Assistance

Synthesis and Biological Properties of some New Lead Sulphonamide and Carboxamide Scaffolds Bearing Coumarin Moiety (Mini Review)

2020 ◽  
Vol 20 ◽  
Author(s):  
Cosmas Chinweike Eze ◽  
Mercy Amarachukwu Ezeokonkwo ◽  
Benjamin Ebere Ezema ◽  
Abraham Efeturi Onoabedje ◽  
David Izuchukwu Ugwu
Keyword(s):  
Biological Properties ◽  
Therapeutic Agents ◽  
Amide Group ◽  
Pharmacological Properties ◽  
Important Class ◽  
Synthetic Route ◽  
Therapeutic Activities

: Coumarin, sulphonamide and amide scaffolds exhibit diverse pharmacological features and constitute an important class of therapeutic agents. In this review, we have discussed the synthesis, biological properties, and SAR of coumarins containing sulphonamide or amide group in the last seven years. Many reviews on the therapeutic activities of coumarins, sulphonamides, and amides have been published, hence the authors focused on coumarin-linked sulphonamide or amide scaffolds. The review provides information on the synthetic route to new coumarins containing sulphonamide or amide groups with improved pharmacological properties.

(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study

2020 ◽  
Vol 17 (5) ◽  
pp. 563-573 ◽  
Author(s):  
Chandrakant Dhondiram Pawar ◽  
Dattatraya Navnath Pansare ◽  
Devanand Baburao Shinde
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Proliferative Activity ◽  
Thiophene Ring ◽  
Amide Group ◽  
Peptide Coupling ◽  
Ic50 Value ◽  
Important Building Block ◽  
Mcf 7

Background: Thiophene ring forms important building block in medicinal chemistry. Literature reveals that thiophene ring in combination with different groups shows different activity. By keeping these things in mind we have designed and synthesized a new series of amide and sulfonamide coupled thiophene. A series of novel substituted 3-sulfamoylbenzo[b]thiophene-4- carboxamide molecules containing sulfonamide and amide group were designed, synthesized and used for anti-proliferative activity study. Methods: The final compounds 16-36 were synthesized by using series of reactions comprising sulfonation, sulfonamide coupling, hydrolysis and peptide coupling. The yields of compounds 16- 36 are in the range of 90-98%. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, LCMS and the purity was checked through HPLC analysis. The compounds were further tested for their in vitro anticancer activity against a series of cell lines A549, HeLa, MCF-7 and Du-145. Results: The intermediates 8-13, 15 and final compounds 16-36 were synthesized in good yields. The synthesized compounds were further tested for their anticancer activity and most of compounds showed moderate to good anticancer activity against all four cell lines. Conclusion: We have synthesized 21 compounds and were screened for anticancer activity against MCF-7, HeLa, A-549 and Du-145 cancer cell lines. Most of the compounds were active for tested cell lines with IC50 value in the range of 1.81 to 9.73 μM. The compounds 18, 19, 21, 25, 30, 31 and 33 are most active in cell line data with IC50 value in the range of 1.81 to 2.52 μM.

scholarly journals Ether Cleavage Re-Investigated: Elucidating the Mechanism of BBr3-Facilitated Demethylation of Aryl Methyl Ethers

2015 ◽  
Vol 2015 (34) ◽  
pp. 7460-7467 ◽  
Author(s):  
Talon M. Kosak ◽  
Heidi A. Conrad ◽  
Andrew L. Korich ◽  
Richard L. Lord
Keyword(s):  
Ether Cleavage ◽  
Aryl Methyl

Catalysis of sulfonate ester hydrolysis by an intramolecular amide group assistance

1985 ◽  
Vol 50 (18) ◽  
pp. 3336-3341 ◽  
Author(s):  
Sergio Thea ◽  
Giuseppe Guanti ◽  
Andrew R. Hopkins ◽  
Andrew Williams
Keyword(s):  
Ester Hydrolysis ◽  
Amide Group ◽  
Sulfonate Ester

Inhibited rotation of amide group around C N bond of nicotinamide in different solvents by 1 H NMR data

2017 ◽  
Vol 231 ◽  
pp. 238-241 ◽  
Author(s):  
G.A. Gamov ◽  
V.V. Aleksandriiskii ◽  
V.A. Sharnin
Keyword(s):  
Amide Group ◽  
H Nmr ◽  
Nmr Data

scholarly journals 4-[(4-Bromophenyl)amino]-2-methylidene-4-oxobutanoic acid

2014 ◽  
Vol 70 (7) ◽  
pp. o779-o780
Author(s):  
B. Narayana ◽  
Prakash S. Nayak ◽  
Balladka K. Sarojini ◽  
Jerry P. Jasinski
Keyword(s):  
Hydrogen Bonds ◽  
Amide Group ◽  
Dihedral Angles ◽  
Asymmetric Unit ◽  
Carboxylic Acid Groups ◽  
Compound C ◽  
Oxobutanoic Acid ◽  
The Mean ◽  
Graph Set ◽  
Independent Molecules

In the title compound, C11H10BrNO3, two independent molecules (AandB) crystallize in the asymmetric unit. The dihedral angles between the mean planes of the 4-bromophenyl ring and amide group are 24.8 (7) in moleculeAand 77.1 (6)° in moleculeB. The mean plane of the methylidene group is further inclined by 75.6 (4) in moleculeAand 72.5 (6)° in moleculeBfrom that of the amide group. In the crystal, N—H...O hydrogen bonds formed by amide groups and O—H...O hydrogen bonds formed by carboxylic acid groups are observed and supported additionally by weak C—H...O interactions between the methylidene and amide groups. Together, these link the molecules into chains of dimers along [110] and formR22(8) graph-set motifs.

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