Studies in Silico-Organic Compounds: XVI. Reactions of Alkyl Thioethers of Silicon with Acetic Anhydride and with Benzoyl Chloride

1951 ◽  
Vol 16 (7) ◽  
pp. 1134-1137 ◽  
Author(s):  
Leon Wolinski ◽  
Howard Tieckelmann ◽  
Howard W. Post
Keyword(s):  
Acetic Anhydride ◽  
Organic Compounds ◽  
In Silico ◽  
Benzoyl Chloride

In silico prediction of binding capacity and interaction forces of organic compounds with α- and β-cyclodextrins

2020 ◽  
Vol 302 ◽  
pp. 112585 ◽  
Author(s):  
Peiwen Di ◽  
Jianhui Chen ◽  
Liping Liu ◽  
Weihua Li ◽  
Yun Tang ◽  
...  
Keyword(s):  
Organic Compounds ◽  
In Silico ◽  
Binding Capacity ◽  
In Silico Prediction ◽  
Interaction Forces

STUDIES IN SILICO-ORGANIC COMPOUNDS. XXVIII. THE PREPARATION OF p-TRIALKYLSILYLPHENYLCARBINOLS

1954 ◽  
Vol 19 (11) ◽  
pp. 1749-1752 ◽  
Author(s):  
PHILIP J. CAMPAGNA ◽  
HOWARD W. POST
Keyword(s):  
Organic Compounds ◽  
In Silico

α-(4-Tolyl)dopamine, derivatives and analogues; Synthesis and pharmacological screening

1983 ◽  
Vol 48 (5) ◽  
pp. 1447-1464 ◽  
Author(s):  
Vladimír Valenta ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Antonín Dlabač ◽  
Marie Bartošová ◽  
...  
Keyword(s):  
Acetic Anhydride ◽  
Hydrobromic Acid ◽  
Benzoyl Chloride ◽  
Substitution Reactions ◽  
Low Degree ◽  
Anticataleptic Activity ◽  
Pharmacological Screening ◽  
Higher Doses ◽  
Hydroxyethyl Piperazine ◽  
Antiarrhythmic Effects

The ketone XIII, obtained by Friedel-Crafts reaction of toluene with homoveratroyl chloride, was converted by the Leuckart reaction to the formamido derivative IXb which was used as the starting product for the synthesis of amines IIIb-Vb. Reduction of the ketone XIII gave the alcohol XVI which was treated with hydrogen chloride and afforded the chloro compound XVII. Its substitution reactions with 1-methylpiperazine, 1-(2-hydroxyethyl)piperazine and 1-phenylpiperazine resulted in the piperazines VIb-VIIIb. Acylations of the amine IIIb with acetic anhydride and homoveratroyl chloride gave the amides Xb and XIb which, together with the formamide IXb, were subjected to the Bischler-Napieralski reaction. 3,4-Dihydroisoquinolines XXII-XXIV were obtained and reduced to the 1,2,3,4-tetrahydroisoquinolines XXVb-XXVIIb. Treatment of XXVIIb with formaldehyde afforded the berbine derivative XXVIII. Demethylation of the amine IIIb with hydrobromic acid resulted in the title compound IIIa. Similar demethylations of the dimethoxyamines IVb-VIIIb, XXVb and XXVIb led to the dihydroxyamines IVa-VIIIa, XXVa and XXVIa which are dopamine derivatives. Reaction of Va with benzoyl chloride gave the dibenzoate XXX. The CNS activities of the compounds prepared are of a low degree. Several of them (IIIa-VIa, IIIb-Vb, XXVb) show in higher doses signs of central stimulant action but only for compound IVa an antireserpine effect was proven. The expected anticataleptic activity was found only in a low degree with compound VIIIa; on the contrary, compounds IIIa and XXVa are procataleptogenic. Some compounds (IIIa, IXb, XXVIa, XXVIII) potentiated thiopental. In single cases local anaesthetic, spasmolytic, hypotensive, hypertensive, hypoglycaemic, diuretic and antiarrhythmic effects were observed.

STUDIES IN SILICO-ORGANIC COMPOUNDS. XV. THE PREPARATION OF ALKYLMERCAPTOSILANES

1951 ◽  
Vol 16 (3) ◽  
pp. 395-398 ◽  
Author(s):  
LEON WOLINSKI ◽  
HOWARD TIECKELMANN ◽  
HOWARD W. POST
Keyword(s):  
Organic Compounds ◽  
In Silico

scholarly journals Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Manal M. El-Shahawi ◽  
Ahmed K. El-Ziaty
Keyword(s):  
Acetic Anhydride ◽  
Building Block ◽  
Benzoyl Chloride ◽  
Heterocyclic Synthesis ◽  
Elemental Analyses ◽  
Nitrogen Nucleophiles

2-Amino-4,5-diphenylfuran-3-carbonitrile 1 was utilized as building block for the construction of new furo[2,3-d]pyrimidin-4(3H)-one derivative 2 and 4H-furo[2,3-d][1,3]oxazin-4-one derivative 3 via treatment with acetic anhydride and benzoyl chloride, respectively. The 4H-furo[2,3-d][1,3]oxazin-4-one derivative 3 was transformed into novel furo[2,3-d]pyrimidin-4(3H)-ones 4–8, tetrazolylfuran derivative 10, and furo[3,2-d]imadazolone derivative 11 via reaction with various nitrogen nucleophiles. The structure features of the synthesized compounds were established from their spectral and elemental analyses.

Sign in / Sign up

Export Citation Format

Share Document