Nucleophilicities and Lewis Basicities of Isothiourea Derivatives

2011 ◽  
Vol 76 (12) ◽  
pp. 5104-5112 ◽  
Author(s):  
Biplab Maji ◽  
Caroline Joannesse ◽  
Tobias A. Nigst ◽  
Andrew D. Smith ◽  
Herbert Mayr
Keyword(s):  
Isothiourea Derivatives

scholarly journals A General Procedure for Conversion of S-Glycosyl Isothiourea Derivatives into Thioglycosides, Thiooligosaccharides and Glycosyl Thioesters

Synthesis ◽  
2004 ◽  
Vol 2001 (07) ◽  
pp. 1110-1110 ◽  
Author(s):  
Farid M. Ibatullin ◽  
StanislavI. Selivanov ◽  
Alexander G. Shavva
Keyword(s):  
General Procedure ◽  
Isothiourea Derivatives

311 Isothiourea derivatives and CK2 inhibitors - a potential proapoptotic and cytostatic agents against astroglial tumours in vitro

2015 ◽  
Vol 51 ◽  
pp. S58
Author(s):  
E.B. Pucko ◽  
M. Koronkiewicz ◽  
Z. Kazimierczuk ◽  
R.P. Ostrowski ◽  
K. Stępień ◽  
...  
Keyword(s):  
Cytostatic Agents ◽  
Isothiourea Derivatives ◽  
Ck2 Inhibitors

A General Procedure for Conversion of S-Glycosyl Isothiourea Derivatives into Thioglycosides, Thiooligosaccharides and Glycosyl Thioesters

Synthesis ◽  
2001 ◽  
Vol 2001 (03) ◽  
pp. 0419-0422 ◽  
Author(s):  
Farid M. Ibatullin ◽  
Stanislav I. Selivanov ◽  
Alexander G. Shavva
Keyword(s):  
General Procedure ◽  
Isothiourea Derivatives

scholarly journals Influence of the type of salt-forming acids on the antiradiation activity of T1023 analogs – salts of N-isobutanoyl-S-isopropylisothiourea

2021 ◽  
Vol 14 (1) ◽  
pp. 68-74
Author(s):  
M. V. Filimonova ◽  
A. S. Saburova ◽  
L. I. Shevchenko ◽  
V. M. Makarchuk ◽  
A. A. Lychagin ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Initial Compound ◽  
Radioprotective Activity ◽  
Nos Inhibitors ◽  
Isothiourea Derivatives ◽  
Antiradiation Activity ◽  
Nos Inhibitor ◽  
New Compounds ◽  
Further Development ◽  
Derivatives Of

According to leading experts, the vast arsenal of radioprotective agents available in the world today does not fully meet modern practical needs, both in the field of radiation protection, and in the prevention and treatment of complications of radiotherapy. The purpose of the study was to evaluate the effect of the salt-forming acids type on the radioprotective activity of NOS inhibitor T1023. The chemical part of this study included methods of chemical synthesis, physicochemical and elemental analysis. Pharmacological part – assessment of acute toxicity using V.B. Prozorovsky express method and the study of radioprotective activity using Till and McCulloch method based on the ability of mice hematopoietic cells to form spleen colonies after irradiation. The number of endogenous hematopoietic spleen colonies were assessed on the 8th day after total exposure to gamma-irradiation at a dose of 6 Gy in six independent experiments. As a result of directed chemical synthesis, six new derivatives of T1023 – salts of N-isobutanoyl-S-isopropylisothiourea have been developed, identified and characterized. The results of studying the safety and radioprotective activity of the synthesized compounds showed that changes in the salt-forming acid don’t significantly influence the toxicity: all studied compounds are in the 3rd class of toxicity and hazard. At the same time, it was found that the replacement of the salt-forming acid significantly influenced the severity of the radioprotective effect. For some of these compounds radioprotective efficacy is comparable to or exceeds the efficacy of the initial compound T1023. It is important to note that these new compounds were used in lower, more save doses than T1023. The results suggest promising further development of NOS inhibitors – isothiourea derivatives as radioprotective agents.

Thiocyanate and Isothiourea Derivatives of Barbituric Acid

1952 ◽  
Vol 74 (2) ◽  
pp. 498-499 ◽  
Author(s):  
Glenn S. Skinner ◽  
William H. Waitz
Keyword(s):  
Barbituric Acid ◽  
Isothiourea Derivatives ◽  
Derivatives Of

Isothiourea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole with broad-spectrum anthelmintic activity

1987 ◽  
Vol 30 (10) ◽  
pp. 1848-1853 ◽  
Author(s):  
Malcolm D. Brewer ◽  
Roderick J. J. Dorgan ◽  
Brian R. Manger ◽  
Patrick Mamalis ◽  
Richard A. B. Webster
Keyword(s):  
Broad Spectrum ◽  
Anthelmintic Activity ◽  
Isothiourea Derivatives ◽  
Derivatives Of

scholarly journals Comparative MD Study of Inhibitory Activity of Opaganib and Adamantane‐Isothiourea Derivatives toward COVID‐19 Main Protease M pro

2021 ◽  
Vol 6 (33) ◽  
pp. 8603-8610
Author(s):  
Jelena Đorović Jovanović ◽  
Marko Antonijević ◽  
Ali A. El‐Emam ◽  
Zoran Marković
Keyword(s):  
Inhibitory Activity ◽  
Main Protease ◽  
Isothiourea Derivatives

scholarly journals Synthesis of isothiourea derivatives.

1989 ◽  
Vol 37 (4) ◽  
pp. 1080-1084 ◽  
Author(s):  
Jiro HORIUCHI ◽  
Kazuo SUZUKI ◽  
Eiki SHITARA ◽  
Ryuji NIWA ◽  
Tetsuzo KATO
Keyword(s):  
Isothiourea Derivatives

Synthesis and antimicrobial and nitric oxide synthase inhibitory activities of novel isothiourea derivatives

2010 ◽  
Vol 33 (6) ◽  
pp. 821-830 ◽  
Author(s):  
Zygmunt Kazimierczuk ◽  
Malgorzata Chalimoniuk ◽  
Agnieszka Ewa Laudy ◽  
Rosa Moo-Puc ◽  
Roberto Cedillo-Rivera ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Isothiourea Derivatives ◽  
Inhibitory Activities ◽  
Oxide Synthase

Novel Isothiourea Derivatives as Potent Neuroprotectors and Cognition Enhancers: Synthesis, Biological and Physicochemical Properties

2009 ◽  
Vol 52 (7) ◽  
pp. 1845-1852 ◽  
Author(s):  
German L. Perlovich ◽  
Alexey N. Proshin ◽  
Tatyana V. Volkova ◽  
Sergey V. Kurkov ◽  
Vlaimir V. Grigoriev ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Isothiourea Derivatives
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