Phosphine-Catalyzed Allylic Substitution of Morita−Baylis−Hillman Acetates:  Synthesis of N-Protected β-Aminophosphonic Acid Esters

2006 ◽  
Vol 71 (20) ◽  
pp. 7892-7894 ◽  
Author(s):  
HaeIl Park ◽  
Chang-Woo Cho ◽  
Michael J. Krische
Keyword(s):  
Allylic Substitution ◽  
Aminophosphonic Acid ◽  
Acid Esters

Use of rhodium complexes with amphiphilic and nonamphiphilic ligands for the preparation of chiral α-aminophosphonic acid esters by hydrogenation in micellar media

1998 ◽  
Vol 9 (23) ◽  
pp. 4193-4202 ◽  
Author(s):  
Ingrid Grassert ◽  
Ute Schmidt ◽  
Silke Ziegler ◽  
Christine Fischer ◽  
Günther Oehme
Keyword(s):  
Rhodium Complexes ◽  
Micellar Media ◽  
Aminophosphonic Acid ◽  
Acid Esters

scholarly journals A Convenient Synthesis and Antibacterial Activity of Novel α-Aminophosphonic Acid Esters from Amino Acids/Esters (Kabachnik-Fields Reaction)

2008 ◽  
Vol 5 (4) ◽  
pp. 679-687 ◽  
Author(s):  
CH. Mohan ◽  
B. Hari Babu ◽  
C. Naga Raju ◽  
R. Usha Nagalakshmi
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Aminophosphonic Acid ◽  
One Pot ◽  
Mass Spectral ◽  
Convenient Synthesis ◽  
Three Component Reaction ◽  
High Yields ◽  
Acid Esters

Synthesis of novel α-aminophosphonic acid esters (5a-n) were achieved with high yields through one-pot three component reaction process by Kabachnik-Fields reaction. It involves the reaction among amino acids/esters, substituted aromatic aldehydes and dialkyl phosphites in absolute ethanol at reflux temperature. Their structures were established by elemental analysis IR,¹H,¹³C,³¹P NMR and mass spectral data. All the title compounds were screened for their antibacterial activity. Most of the compounds exhibited moderate antimicrobial activity.

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