ChemInform Abstract: AMINO PHOSPHONIC ACIDS. PART VI. DIAZOMETHANE AS A REAGENT IN THE SYNTHESIS OF N-ACYLATED 1-AMINOPHOSPHONIC ACID ESTERS

1976 ◽  
Vol 7 (21) ◽  
pp. no-no ◽  
Author(s):  
MARIA HOFFMANN ◽  
CZESLAW WASIELEWSKI
Keyword(s):  
Aminophosphonic Acid ◽  
Phosphonic Acids ◽  
Acid Esters

scholarly journals Straightforward Immobilization of Phosphonic Acids and Phosphoric Acid Esters on Mesoporous Silica and Their Application in an Asymmetric Aldol Reaction

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 249 ◽  
Author(s):  
Christian Weinberger ◽  
Tatjana Heckel ◽  
Patrick Schnippering ◽  
Markus Schmitz ◽  
Anpeng Guo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Phosphoric Acid ◽  
Surface Area ◽  
Aldol Reaction ◽  
Synthesis Method ◽  
Mesoporous Silicas ◽  
Phosphonic Acids ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
Acid Esters

The combined benefits of moisture-stable phosphonic acids and mesoporous silica materials (SBA-15 and MCM-41) as large-surface-area solid supports offer new opportunities for several applications, such as catalysis or drug delivery. We present a comprehensive study of a straightforward synthesis method via direct immobilization of several phosphonic acids and phosphoric acid esters on various mesoporous silicas in a Dean–Stark apparatus with toluene as the solvent. Due to the utilization of azeotropic distillation, there was no need to dry phosphonic acids, phosphoric acid esters, solvents, or silicas prior to synthesis. In addition to modeling phosphonic acids, immobilization of the important biomolecule adenosine monophosphate (AMP) on the porous supports was also investigated. Due to the high surface area of the mesoporous silicas, a possible catalytic application based on immobilization of an organocatalyst for an asymmetric aldol reaction is discussed.

Organophosphorus Compounds. II. Preparation of Phosphonic Acid Esters using the Dicyclohexylcarbodiimide Reagent

1963 ◽  
Vol 16 (4) ◽  
pp. 609 ◽  
Author(s):  
JA Maynard ◽  
JM Swan
Keyword(s):  
Phosphonic Acid ◽  
Organophosphorus Compounds ◽  
Phosphonic Acids ◽  
Pyridine Solution ◽  
Acid Esters

Mono- and diesters of phosphonic acids are conveniently prepared by reaction of a phosphonic acid with appropriate quantities of NN'-dicyclohexylcarbodiimide and an alcohol or phenol in pyridine solution.

Use of rhodium complexes with amphiphilic and nonamphiphilic ligands for the preparation of chiral α-aminophosphonic acid esters by hydrogenation in micellar media

1998 ◽  
Vol 9 (23) ◽  
pp. 4193-4202 ◽  
Author(s):  
Ingrid Grassert ◽  
Ute Schmidt ◽  
Silke Ziegler ◽  
Christine Fischer ◽  
Günther Oehme
Keyword(s):  
Rhodium Complexes ◽  
Micellar Media ◽  
Aminophosphonic Acid ◽  
Acid Esters

scholarly journals A Convenient Synthesis and Antibacterial Activity of Novel α-Aminophosphonic Acid Esters from Amino Acids/Esters (Kabachnik-Fields Reaction)

2008 ◽  
Vol 5 (4) ◽  
pp. 679-687 ◽  
Author(s):  
CH. Mohan ◽  
B. Hari Babu ◽  
C. Naga Raju ◽  
R. Usha Nagalakshmi
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Aminophosphonic Acid ◽  
One Pot ◽  
Mass Spectral ◽  
Convenient Synthesis ◽  
Three Component Reaction ◽  
High Yields ◽  
Acid Esters

Synthesis of novel α-aminophosphonic acid esters (5a-n) were achieved with high yields through one-pot three component reaction process by Kabachnik-Fields reaction. It involves the reaction among amino acids/esters, substituted aromatic aldehydes and dialkyl phosphites in absolute ethanol at reflux temperature. Their structures were established by elemental analysis IR,¹H,¹³C,³¹P NMR and mass spectral data. All the title compounds were screened for their antibacterial activity. Most of the compounds exhibited moderate antimicrobial activity.

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