Construction of a 2,6-Difunctionalized 2-Methyl-2H-1-benzopyran Library by Using a Solid-Phase Synthesis Protocol

2005 ◽  
Vol 70 (24) ◽  
pp. 10151-10154 ◽  
Author(s):  
Jong Yeon Hwang ◽  
Hyung-Sub Choi ◽  
Jin-soo Seo ◽  
Hyun Ju La ◽  
Dong-Soo Kim ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Synthesis Protocol

scholarly journals Parallel solid-phase synthesis of diaryltriazoles

2012 ◽  
Vol 8 ◽  
pp. 1027-1036 ◽  
Author(s):  
Matthias Wrobel ◽  
Jeffrey Aubé ◽  
Burkhard König
Keyword(s):  
Protein Interactions ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Alpha Helix ◽  
Protein Protein Interactions ◽  
Phase Synthesis ◽  
Wang Resin ◽  
Polymer Bead ◽  
Synthesis Protocol ◽  
Parallel Fashion

A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein–protein interactions.

Acyclic analogs of nucleosides based on tris(hydroxymethyl)phosphine oxide: synthesis and incorporation into short DNA oligomers

2015 ◽  
Vol 21 (5) ◽  
pp. 303-314 ◽  
Author(s):  
Barbara Nawrot ◽  
Olga Michalak ◽  
Barbara Mikołajczyk ◽  
Wojciech J. Stec
Keyword(s):  
Phosphine Oxide ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Hydroxyl Groups ◽  
Dna Oligomers ◽  
Phase Synthesis ◽  
Complementary Dna ◽  
Dna Analogs ◽  
Dna Strands ◽  
Synthesis Protocol

AbstractTris-(hydroxymethyl)phosphine oxide (THPO) to a certain extent resembles a part of 2′-deoxyribofuranose, although it exists in an acyclic form only and the oxygen atom at the THPO phosphorus center provides additional hydration site or acceptor of hydrogen bonds. After proper protection of hydroxyl groups, THPO was functionalized with nucleobases and converted into phosphoramidite monomers suitable for incorporation into growing oligonucleotide chains within the solid phase synthesis protocol. The resultant THPO-DNA analogs show reduced affinity to complementary DNA strands, and are resistant towards snake venom and calf spleen exonucleases.

Sign in / Sign up

Export Citation Format

Share Document