Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes:  Synthesis and Biological Evaluation of HIV-Protease Inhibitors

Reiko Yanada; Yasuhiro Koh; Nobuaki Nishimori; Akira Matsumura; Shingo Obika; Hiroaki Mitsuya; Nobutaka Fujii; Yoshiji Takemoto

doi:10.1021/jo035482m

Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation of HIV-Protease Inhibitors

The Journal of Organic Chemistry ◽

10.1021/jo035482m ◽

2004 ◽

Vol 69 (7) ◽

pp. 2417-2422 ◽

Cited By ~ 48

Author(s):

Reiko Yanada ◽

Yasuhiro Koh ◽

Nobuaki Nishimori ◽

Akira Matsumura ◽

Shingo Obika ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Radical Cyclizations ◽

Hiv Protease Inhibitors ◽

Atom Transfer ◽

Synthesis And Biological Evaluation

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Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation of HIV-Protease Inhibitors.

ChemInform ◽

10.1002/chin.200432051 ◽

2004 ◽

Vol 35 (32) ◽

Author(s):

Reiko Yanada ◽

Yasuhiro Koh ◽

Nobuaki Nishimori ◽

Akira Matsumura ◽

Shingo Obika ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Radical Cyclizations ◽

Hiv Protease Inhibitors ◽

Atom Transfer ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00261-3 ◽

2001 ◽

Vol 9 (2) ◽

pp. 417-430 ◽

Cited By ~ 12

Author(s):

Hikaru Matsumoto ◽

Takashi Matsuda ◽

Shingo Nakata ◽

Takatoshi Mitoguchi ◽

Tooru Kimura ◽

...

Keyword(s):

Carboxylic Acid ◽

Protease Inhibitors ◽

Transcriptase Inhibitor ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Reverse Transcriptase Inhibitor ◽

Anti Hiv Agents ◽

Synthesis And Biological Evaluation ◽

Anti Hiv

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Synthesis and biological evaluation in vitro and in mammalian cells of new heteroaryl carboxyamides as HIV-protease inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.07.014 ◽

2017 ◽

Vol 25 (17) ◽

pp. 4715-4722 ◽

Cited By ~ 1

Author(s):

M. Funicello ◽

L. Chiummiento ◽

F. Tramutola ◽

M.F. Armentano ◽

F. Bisaccia ◽

...

Keyword(s):

Protease Inhibitors ◽

Mammalian Cells ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.199649167 ◽

2010 ◽

Vol 27 (49) ◽

pp. no-no

Author(s):

A. K. GHOSH ◽

J. F. KINCAID ◽

D. E. WALTERS ◽

Y. CHEN ◽

N. C. CHAUDHURI ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Nonpeptidal P2Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/jm960128k ◽

1996 ◽

Vol 39 (17) ◽

pp. 3278-3290 ◽

Cited By ~ 68

Author(s):

Arun K. Ghosh ◽

John F. Kincaid ◽

D. Eric Walters ◽

Yan Chen ◽

Narayan C. Chaudhuri ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of new simple indolic non peptidic HIV Protease inhibitors: The effect of different substitution patterns

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.06.055 ◽

2014 ◽

Vol 22 (17) ◽

pp. 4792-4802 ◽

Cited By ~ 9

Author(s):

C. Bonini ◽

L. Chiummiento ◽

N. Di Blasio ◽

M. Funicello ◽

P. Lupattelli ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and in vitro biological evaluation of valine-containing prodrugs derived from clinically used HIV-protease inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2007.08.016 ◽

2008 ◽

Vol 43 (7) ◽

pp. 1506-1518 ◽

Cited By ~ 4

Author(s):

Dominique Roche ◽

Jacques Greiner ◽

Anne-Marie Aubertin ◽

Pierre Vierling

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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Synthesis and in Vitro Biological Evaluation of Mannose-Containing Prodrugs Derived from Clinically Used HIV-Protease Inhibitors with Improved Transepithelial Transport

Bioconjugate Chemistry ◽

10.1021/bc060210m ◽

2006 ◽

Vol 17 (6) ◽

pp. 1568-1581 ◽

Cited By ~ 4

Author(s):

Dominique Roche ◽

Jacques Greiner ◽

Anne-Marie Aubertin ◽

Pierre Vierling

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Transepithelial Transport ◽

Hiv Protease Inhibitors

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Determining and Overcoming Resistance to HIV Protease Inhibitors

Current Drug Targets - Infectious Disorders ◽

10.2174/1568005043340984 ◽

2004 ◽

Vol 4 (2) ◽

pp. 137-152 ◽

Cited By ~ 17

Author(s):

Jana Prejdova ◽

Milan Soucek ◽

Jan Konvalinka

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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A QSAR Study of HIV Protease Inhibitors Using Theoretical Descriptors

Current Computer - Aided Drug Design ◽

10.2174/1573409911006040269 ◽

2010 ◽

Vol 6 (4) ◽

pp. 269-282 ◽

Cited By ~ 4

Author(s):

Subhash C. Basak ◽

Denise Mills ◽

Rajni Garg ◽

Barun Bhhatarai

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Qsar Study

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