Nonpeptidal P2Ligands for HIV Protease Inhibitors:  Structure-Based Design, Synthesis, and Biological Evaluation

Arun K. Ghosh; John F. Kincaid; D. Eric Walters; Yan Chen; Narayan C. Chaudhuri; Wayne J. Thompson; Chris Culberson; Paula M. D. Fitzgerald; Hee Yoon Lee; Sean P. McKee; Peter M. Munson; Tien T. Duong; Paul L. Darke; Joan A. Zugay; William A. Schleif; Melinda G. Axel; Juinn Lin; Joel R. Huff

doi:10.1021/jm960128k

Nonpeptidal P2Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/jm960128k ◽

1996 ◽

Vol 39 (17) ◽

pp. 3278-3290 ◽

Cited By ~ 68

Author(s):

Arun K. Ghosh ◽

John F. Kincaid ◽

D. Eric Walters ◽

Yan Chen ◽

Narayan C. Chaudhuri ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.199649167 ◽

2010 ◽

Vol 27 (49) ◽

pp. no-no

Author(s):

A. K. GHOSH ◽

J. F. KINCAID ◽

D. E. WALTERS ◽

Y. CHEN ◽

N. C. CHAUDHURI ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation of HIV-Protease Inhibitors.

ChemInform ◽

10.1002/chin.200432051 ◽

2004 ◽

Vol 35 (32) ◽

Author(s):

Reiko Yanada ◽

Yasuhiro Koh ◽

Nobuaki Nishimori ◽

Akira Matsumura ◽

Shingo Obika ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Radical Cyclizations ◽

Hiv Protease Inhibitors ◽

Atom Transfer ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00261-3 ◽

2001 ◽

Vol 9 (2) ◽

pp. 417-430 ◽

Cited By ~ 12

Author(s):

Hikaru Matsumoto ◽

Takashi Matsuda ◽

Shingo Nakata ◽

Takatoshi Mitoguchi ◽

Tooru Kimura ◽

...

Keyword(s):

Carboxylic Acid ◽

Protease Inhibitors ◽

Transcriptase Inhibitor ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Reverse Transcriptase Inhibitor ◽

Anti Hiv Agents ◽

Synthesis And Biological Evaluation ◽

Anti Hiv

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Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation of HIV-Protease Inhibitors

The Journal of Organic Chemistry ◽

10.1021/jo035482m ◽

2004 ◽

Vol 69 (7) ◽

pp. 2417-2422 ◽

Cited By ~ 48

Author(s):

Reiko Yanada ◽

Yasuhiro Koh ◽

Nobuaki Nishimori ◽

Akira Matsumura ◽

Shingo Obika ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Radical Cyclizations ◽

Hiv Protease Inhibitors ◽

Atom Transfer ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation in vitro and in mammalian cells of new heteroaryl carboxyamides as HIV-protease inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.07.014 ◽

2017 ◽

Vol 25 (17) ◽

pp. 4715-4722 ◽

Cited By ~ 1

Author(s):

M. Funicello ◽

L. Chiummiento ◽

F. Tramutola ◽

M.F. Armentano ◽

F. Bisaccia ◽

...

Keyword(s):

Protease Inhibitors ◽

Mammalian Cells ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of new simple indolic non peptidic HIV Protease inhibitors: The effect of different substitution patterns

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.06.055 ◽

2014 ◽

Vol 22 (17) ◽

pp. 4792-4802 ◽

Cited By ~ 9

Author(s):

C. Bonini ◽

L. Chiummiento ◽

N. Di Blasio ◽

M. Funicello ◽

P. Lupattelli ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Synthesis And Biological Evaluation

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies

Journal of Medicinal Chemistry ◽

10.1021/jm9800696 ◽

1998 ◽

Vol 41 (15) ◽

pp. 2819-2834 ◽

Cited By ~ 49

Author(s):

Peter S. Dragovich ◽

Stephen E. Webber ◽

Robert E. Babine ◽

Shella A. Fuhrman ◽

Amy K. Patick ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Peptide Structure ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport

Journal of the American Chemical Society ◽

10.1021/ja00150a011 ◽

1995 ◽

Vol 117 (45) ◽

pp. 11113-11123 ◽

Cited By ~ 38

Author(s):

Amos B Smith ◽

Ralph Hirschmann ◽

Alexander Pasternak ◽

Mark C. Guzman ◽

Akihisa Yokoyama ◽

...

Keyword(s):

Antiviral Activity ◽

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Design Synthesis

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Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors Possessing Augmented P2′ Side Chains.

ChemInform ◽

10.1002/chin.200619097 ◽

2006 ◽

Vol 37 (19) ◽

Author(s):

Amos B. III Smith ◽

et al. et al.

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Side Chains ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis and biological evaluation of HIV-1 protease inhibitors with morpholine derivatives as P2 ligands in combination with cyclopropyl as P1′ ligand

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127019 ◽

2020 ◽

Vol 30 (7) ◽

pp. 127019 ◽

Cited By ~ 1

Author(s):

Yue Dou ◽

Mei Zhu ◽

Biao Dong ◽

Ju-Xian Wang ◽

Guo-Ning Zhang ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Morpholine Derivatives ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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