Ultraviolet Absorption Spectra of Some Hydroxamic Acids and Hydroxamic Acid Derivatives

1959 ◽  
Vol 24 (6) ◽  
pp. 802-804 ◽  
Author(s):  
ROBERT E. PLAPINGER
Keyword(s):  
Absorption Spectra ◽  
Hydroxamic Acid ◽  
Hydroxamic Acids ◽  
Ultraviolet Absorption ◽  
Hydroxamic Acid Derivatives

Hydroxamic acids. III. Mass spectra of substituted hydroxamic acids and cyclic imides

1969 ◽  
Vol 22 (1) ◽  
pp. 175 ◽  
Author(s):  
JH Bowie ◽  
MTW Hearn ◽  
AD Ward
Keyword(s):  
Electron Impact ◽  
Hydroxamic Acid ◽  
Mass Spectra ◽  
Hydroxamic Acids ◽  
Skeletal Rearrangement ◽  
Cyclic Imides ◽  
Derivatives Of ◽  
Hydroxamic Acid Derivatives

Aryl hydroxamic acid derivatives fragment in a diagnostic manner upon electron impact. A hydroxamic acid containing both styryl and benzyl substituents undergoes skeletal-rearrangement of the type ABC → AC+B. The mass spectra of the O- and N-acetyl derivatives of O- benzylhydroxamic acids are indistinguishable. M-CO2 fragments are again observed in the mass spectra of several substituted phthalimides.

N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones

2021 ◽  
Vol 19 (11) ◽  
pp. 2442-2447
Author(s):  
Daisuke Shimbo ◽  
Toshifumi Maruyama ◽  
Norihiro Tada ◽  
Akichika Itoh
Keyword(s):  
Amino Acids ◽  
Hydroxamic Acid ◽  
Hydroxamic Acids ◽  
Hydroxamic Acid Derivatives

Ethynyl benziodoxolone enabled the chemoselective N-functionalization of O-alkyl hydroxamic acids derived from amino acids and pharmaceuticals. The synthesized cis-vinyl benziodoxolone was derivatized to hydroxamic acid-derived enamides.

Design, synthesis, and preliminary bioactivity studies of substituted purine hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors

MedChemComm ◽  
2014 ◽  
Vol 5 (12) ◽  
pp. 1887-1891 ◽  
Author(s):  
Junhua Wang ◽  
Feng'e Sun ◽  
Leiqiang Han ◽  
Xuben Hou ◽  
Xiaole Pan ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Hydroxamic Acid ◽  
Tumor Therapy ◽  
Hdac Inhibitors ◽  
Hydroxamic Acids ◽  
Hdac Inhibition ◽  
Design Synthesis ◽  
Hydroxamic Acid Derivatives

Histone deacetylase (HDAC) is a clinically validated target for anti-tumor therapy. In order to increase HDAC inhibition and efficiency, we developed a series of novel substituted purine hydroxamic acids as potent HDAC inhibitors.

FAR ULTRAVIOLET ABSORPTION SPECTRA OF N3AND N2+GENERATED BY ELECTRONS IMPACTING GASEOUS N2

2013 ◽  
Vol 779 (1) ◽  
pp. 40 ◽  
Author(s):  
Yu-Jong Wu ◽  
Hui-Fen Chen ◽  
Shiang-Jiun Chuang ◽  
Tzu-Ping Huang
Keyword(s):  
Absorption Spectra ◽  
Ultraviolet Absorption ◽  
Far Ultraviolet

scholarly journals ULTRAVIOLET ABSORPTION SPECTRA AT REDUCED TEMPERATURES

1950 ◽  
Vol 187 (1) ◽  
pp. 299-312
Author(s):  
R.L. Sinsheimer ◽  
J.F. Scott ◽  
J.R. Loofbourow
Keyword(s):  
Absorption Spectra ◽  
Ultraviolet Absorption

ULTRAVIOLET ABSORPTION SPECTRA AND ACIDITIES OF ISOMERIC THIATRIAZOLE AND TETRAZOLE DERIVATIVES

1959 ◽  
Vol 37 (3) ◽  
pp. 563-574 ◽  
Author(s):  
Eugene Lieber ◽  
J. Ramachandran ◽  
C. N. R. Rao ◽  
C. N. Pillai
Keyword(s):  
Absorption Spectra ◽  
Absorption Maximum ◽  
Dipole Moments ◽  
Ring System ◽  
Ultraviolet Absorption ◽  
Characteristic Absorption ◽  
Tetrazole Derivatives

The ultraviolet absorption spectra of 5-(substituted)amino-1,2,3,4-thiatriazoles and the corresponding isomeric 1-substituted-tetrazoline-5-thiones have been studied. The spectra and the dipole moments of the 5-(substituted)amino-1,2,3,4-thiatriazoles eliminate the possibility of meso-ionic structures for these compounds. The dipole moments of 5-amino-, 5-methylamino-, and 5-dimethylamino-1,2,3,4-thiatriazole were all high but approximately of the same value (5.77 to 5.84 D). This suggests that the amino thiatriazoles are best represented by conventional covalent structures with significant ionic resonance contributions. The thiatriazole ring system exhibits a characteristic absorption maximum at 250–255 mμ and an electron-withdrawing effect approximately equal to the tetrazolyl ring system. The tetrazolinethionolyl ring system is similarly electron-withdrawing. The relative acidities of the 1-substituted-tetrazoline-5-thiones and the 5-alkylmercaptotetrazoles have also been studied and the results support the observations made on the basis of their ultraviolet absorption spectra.

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