Synthesis of 4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo[1,2-a]purine and the "Y" base from Saccharomyces cerevisiae phenylalanine transfer RNA

1978 ◽  
Vol 43 (9) ◽  
pp. 1644-1649 ◽  
Author(s):  
Charles R. Frihart ◽  
Aaron M. Feinberg ◽  
Koji Nakanishi
Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 380 ◽  
Author(s):  
Pengmian Feng ◽  
Zhaochun Xu ◽  
Hui Yang ◽  
Hao Lv ◽  
Hui Ding ◽  
...  

As an abundant post-transcriptional modification, dihydrouridine (D) has been found in transfer RNA (tRNA) from bacteria, eukaryotes, and archaea. Nonetheless, knowledge of the exact biochemical roles of dihydrouridine in mediating tRNA function is still limited. Accurate identification of the position of D sites is essential for understanding their functions. Therefore, it is desirable to develop novel methods to identify D sites. In this study, an ensemble classifier was proposed for the detection of D modification sites in the Saccharomyces cerevisiae transcriptome by using heterogeneous features. The jackknife test results demonstrate that the proposed predictor is promising for the identification of D modification sites. It is anticipated that the proposed method can be widely used for identifying D modification sites in tRNA.


PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0229103
Author(s):  
Lauren Endres ◽  
Rebecca E. Rose ◽  
Frank Doyle ◽  
Taylor Rahn ◽  
Bethany Lee ◽  
...  

Genetics ◽  
1973 ◽  
Vol 73 (1) ◽  
pp. 23-28
Author(s):  
John A Kiger ◽  
Carol J Brantner

ABSTRACT Transfer RNA from super-suppressor mutants of Saccharomyces cerevisiae cannot suppress an amber mutation in vitro in an E. coli protein synthesizing system. It is tentatively concluded that the yeast amber suppressor does not contain a transfer RNA altered in the anticodon.


1976 ◽  
Vol 145 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Hiroshi Fukuhara ◽  
Monique Bolotin-Fukuhara ◽  
Huey-Juang Hsu ◽  
Murray Rabinowitz

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