Pyridopyrimidines. 9. An unusual rearrangement in the 8-substituted pyrido[2,3-d]pyrimidine series. Application of the selective nuclear Overhauser effect to unambiguous proton chemical shift assignment

1978 ◽  
Vol 43 (5) ◽  
pp. 828-834 ◽  
Author(s):  
Ananthachari Srinivasan ◽  
Paul E. Fagerness ◽  
Arthur D. Broom
Keyword(s):  
Chemical Shift ◽  
Nuclear Overhauser Effect ◽  
Chemical Shift Assignment ◽  
Proton Chemical Shift ◽  
Overhauser Effect ◽  
Unusual Rearrangement ◽  
Pyrimidine Series ◽  
Nuclear Overhauser ◽  
Shift Assignment

An evaluation of high resolution nuclear magnetic resonance experiments and protocols in the structure elucidation of organic molecules. I. A relatively simple system, brucine

1985 ◽  
Vol 63 (2) ◽  
pp. 483-490 ◽  
Author(s):  
Michael A. Bernstein ◽  
Laurance D. Hall
Keyword(s):  
High Resolution ◽  
Chemical Shift ◽  
Structural Information ◽  
Nuclear Overhauser Effect ◽  
Proton Spectrum ◽  
Nmr Spectrum ◽  
H Nmr ◽  
Overhauser Effect ◽  
Nuclear Overhauser ◽  
Nmr Methods

Using a combination of one-dimensional (1D) and two-dimensional (2D) high resolution nmr methods, the 1H nmr spectrum of brucine was fully assigned. The 2D J-resolved and homonuclear chemical shift correlated (COSY) experiments provided assignments without full structural information; this was obtained from nuclear Overhauser effect (nOe) enhancement experiments (1D and 2D). With the proton spectrum fully assigned, proton-bearing carbons in the 13C nmr spectrum were easily assigned using the 2D heteronuclear chemical shift correlation map (CSCM) experiment.

1H NMR studies of [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: cis-trans Isomerism of the His-Pro bond

1990 ◽  
Vol 55 (4) ◽  
pp. 1106-1111 ◽  
Author(s):  
John Matsoukas ◽  
Paul Cordopatis ◽  
Raghav Yamdagni ◽  
Graham J. Moore
Keyword(s):  
1H Nmr ◽  
Nuclear Overhauser Effect ◽  
Nmr Studies ◽  
Restricted Rotation ◽  
Overhauser Effect ◽  
Major Isomer ◽  
Conformational Properties ◽  
Nuclear Overhauser

The conformational properties of the Sarmesin analogues [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in hexadeutero-dimethysulfoxide were investigated by Nuclear Overhauser Effect (NOE) Enhancement Studies. Cis-trans isomers (ratio 1 : 6) due to restricted rotation of the His-Pro bond were observed. Interresidue interactions between the His Cα proton and the two Pro Cδ protons revealed that the major isomer was the trans.

scholarly journals Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1080
Author(s):  
Imran Khan ◽  
Jing Peng ◽  
Zhuangjie Fang ◽  
Wei Liu ◽  
Wenjun Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Nuclear Overhauser Effect ◽  
Inhibition Activity ◽  
Tyrosinase Inhibition ◽  
Bioactive Natural Products ◽  
Chemical Structures ◽  
Overhauser Effect ◽  
Spectroscopic Analyses ◽  
Potential Resource ◽  
Nuclear Overhauser

The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.

scholarly journals 1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2

2021 ◽  
Author(s):  
Christian Richter ◽  
Katharina F. Hohmann ◽  
Sabrina Toews ◽  
Daniel Mathieu ◽  
Nadide Altincekic ◽  
...  
Keyword(s):  
Life Cycle ◽  
Chemical Shift ◽  
Base Pair ◽  
Chemical Shift Assignment ◽  
Potential Functions ◽  
Regulatory Rna ◽  
Structural Element ◽  
Stem Loop ◽  
Internal Loop ◽  
Shift Assignment

AbstractThe stem-loop (SL1) is the 5'-terminal structural element within the single-stranded SARS-CoV-2 RNA genome. It is formed by nucleotides 7–33 and consists of two short helical segments interrupted by an asymmetric internal loop. This architecture is conserved among Betacoronaviruses. SL1 is present in genomic SARS-CoV-2 RNA as well as in all subgenomic mRNA species produced by the virus during replication, thus representing a ubiquitous cis-regulatory RNA with potential functions at all stages of the viral life cycle. We present here the 1H, 13C and 15N chemical shift assignment of the 29 nucleotides-RNA construct 5_SL1, which denotes the native 27mer SL1 stabilized by an additional terminal G-C base-pair.

Sign in / Sign up

Export Citation Format

Share Document