500-MHz proton NMR study of poly(dG).cntdot.poly(dC) in solution using one-dimensional nuclear Overhauser effect

Biochemistry ◽  
1986 ◽  
Vol 25 (12) ◽  
pp. 3659-3665 ◽  
Author(s):  
Mukti H. Sarma ◽  
Goutam Gupta ◽  
Ramaswamy H. Sarma
Keyword(s):  
Nuclear Overhauser Effect ◽  
Proton Nmr ◽  
One Dimensional ◽  
Overhauser Effect ◽  
Nmr Study ◽  
Nuclear Overhauser

scholarly journals Benderamide A, a Cyclic Depsipeptide from a Singapore Collection of Marine Cyanobacterium cf. Lyngbya sp.

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 409 ◽  
Author(s):  
Chi Ding ◽  
Ji Ong ◽  
Hui Goh ◽  
Cynthia Coffill ◽  
Lik Tan
Keyword(s):  
Breast Cancer Cells ◽  
Nuclear Overhauser Effect ◽  
2D Nmr ◽  
Marine Cyanobacterium ◽  
One Dimensional ◽  
Mechanistic Pathway ◽  
Overhauser Effect ◽  
Cyclic Depsipeptide ◽  
Nuclear Overhauser ◽  
Related Compounds

Benderamide A (1), a (S)-2,2-dimethyl-3-hydroxy-7-octynoic acid (S-Dhoya)-containing cyclic depsipeptide that belongs to the kulolide superfamily, was isolated from a Singapore collection of cf. Lyngbya sp. marine cyanobacterium using a bioassay-guided approach. While the planar structure of 1 was elucidated using a combination of 1D and 2D NMR experiments and MS analysis, the absolute configuration was subsequently achieved using the results obtained from Marfey’s analysis, comparative analysis of nuclear overhauser effect spectroscopy (NOESY) with the known compound 3, and one dimensional-nuclear overhauser effect (1D-NOE). Although 1 did not display antiproliferative activity against MCF7 breast cancer cells, the presence of an Ala instead of Gly suggests a possible mechanistic pathway to explain the consequential decrease in cytotoxicity compared to the closely related 2. In addition, results obtained from an LC–MS/MS-based molecular networking algorithm revealed two other closely related compounds encouraging further identification and isolation from the same marine cyanobacterium extract.

Isotopic-label-directed observation of the nuclear Overhauser effect in poorly resolved proton NMR spectra

1985 ◽  
Vol 107 (3) ◽  
pp. 711-712 ◽  
Author(s):  
R. H. Griffey ◽  
M. A. Jarema ◽  
S. Kunz ◽  
P. R. Rosevear ◽  
A. G. Redfield
Keyword(s):  
Nmr Spectra ◽  
Nuclear Overhauser Effect ◽  
Proton Nmr ◽  
Isotopic Label ◽  
Overhauser Effect ◽  
Nuclear Overhauser
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