Practical approach to high-yield enzymic stereospecific organic synthesis in multiphase systems

1981 ◽  
Vol 46 (15) ◽  
pp. 3128-3131 ◽  
Author(s):  
Marie Jose De Smet ◽  
Bernard Witholt ◽  
Hans Wynberg
Keyword(s):  
Organic Synthesis ◽  
Practical Approach ◽  
High Yield ◽  
Multiphase Systems

Effect of Metal Ions in Organic Synthesis; XVII. Mild, Easy, and High-Yield Conversion of Aldoximes into Nitriles under Copper(II) Acetate-Catalysis

Synthesis ◽  
1983 ◽  
Vol 1983 (09) ◽  
pp. 741-742 ◽  
Author(s):  
Orazio Attanasi ◽  
Pierangela Palma ◽  
Franco Serra-Zanetti
Keyword(s):  
Metal Ions ◽  
Organic Synthesis ◽  
High Yield

scholarly journals Synthesis of (Z)-Cinnamate Derivatives via Visible-Light-Driven E-to-Z Isomerization

SynOpen ◽  
2019 ◽  
Vol 03 (04) ◽  
pp. 103-107 ◽  
Author(s):  
Penghua Shu ◽  
Haichang Xu ◽  
Lingxiang Zhang ◽  
Junping Li ◽  
Hao Liu ◽  
...  
Keyword(s):  
Visible Light ◽  
Organic Synthesis ◽  
Blue Light ◽  
Large Scale ◽  
Practical Approach ◽  
Efficient Synthesis ◽  
Synthetic Methodology ◽  
Visible Light Driven ◽  
Large Scale Synthesis

(Z)-Cinnamate derivatives are prevalent in natural bioactive products and in organic synthesis. Herein, we report a practical approach toward the efficient synthesis of (Z)-cinnamate derivatives via visible-light-driven isomerization. When E-isomers of cinnamate derivatives were irradiated with blue light in the presence of 1 mol% Ir2(ppy)4Cl2 (ppy = 2-phenylpyridine), Z-isomers were readily obtained in good yields. This strategy allows the large-scale synthesis of (Z)-cinnamate derivatives with simple purification. This convenient, mild, and green synthetic methodology was subsequently applied to the synthesis of coumarins.

scholarly journals Zeolites Catalyze the Nazarov Reaction and the tert-Butylation of Alcohols by Stabilization of Carboxonium Intermediates

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2031-2037
Author(s):  
Antonio Leyva-Pérez ◽  
María Tejeda-Serrano ◽  
Sergio Sanz-Navarro ◽  
Finn Blake
Keyword(s):  
Organic Synthesis ◽  
Butyl Acetate ◽  
Strong Acid ◽  
Organic Reactions ◽  
High Yield ◽  
Acid Catalysts ◽  
Nazarov Cyclization ◽  
Triflic Acid ◽  
Nazarov Reaction ◽  
Tert Butyl

Zeolites are the most used catalysts worldwide in petrochemistry processes, with particular ability to stabilize carbocations. However, the use of zeolites in organic synthesis is still scarce. We show here that representative carboxonium-mediated organic reactions, such as the Nazarov cyclization and the tert-butylation of alcohols with tert-butyl acetate, typically performed with very strong acid catalysts in solution such as triflic acid, can be catalyzed by simple zeolites with high yield and selectivity. The aluminosilicate framework stabilizes the intermediate carboxonium species and overrides the need for superacid protons in solution.

scholarly journals The chemistry of bisallenes

2012 ◽  
Vol 8 ◽  
pp. 1936-1998 ◽  
Author(s):  
Henning Hopf ◽  
Georgios Markopoulos
Keyword(s):  
Structural Properties ◽  
Organic Synthesis ◽  
High Yield ◽  
Cycloaddition Reactions ◽  
Atom Economy ◽  
Ring Systems ◽  
Target Molecules ◽  
Molecular Complexity ◽  
First Time

This review describes the preparation, structural properties and the use of bisallenes in organic synthesis for the first time. All classes of compounds containing at least two allene moieties are considered, starting from simple conjugated bisallenes and ending with allenes in which the two cumulenic units are connected by complex polycyclic ring systems, heteroatoms and/or heteroatom-containing tethers. Preparatively the bisallenes are especially useful in isomerization and cycloaddition reactions of all kinds leading to the respective target molecules with high atom economy and often in high yield. Bisallenes are hence substrates for generating molecular complexity in a small number of steps (high step economy).

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