ChemInform Abstract: ULTRASOUNDS IN ORGANIC SYNTHESIS. 3. A SIMPLE, HIGH YIELD MODIFICATION OF THE E BOUVEAULT REACTION

1983 ◽  
Vol 14 (1) ◽  
Author(s):  
C. PETRIER ◽  
A. L. GEMAL ◽  
J.-L. LUCHE
Keyword(s):  
Organic Synthesis ◽  
High Yield

Effect of Metal Ions in Organic Synthesis; XVII. Mild, Easy, and High-Yield Conversion of Aldoximes into Nitriles under Copper(II) Acetate-Catalysis

Synthesis ◽  
1983 ◽  
Vol 1983 (09) ◽  
pp. 741-742 ◽  
Author(s):  
Orazio Attanasi ◽  
Pierangela Palma ◽  
Franco Serra-Zanetti
Keyword(s):  
Metal Ions ◽  
Organic Synthesis ◽  
High Yield

scholarly journals Zeolites Catalyze the Nazarov Reaction and the tert-Butylation of Alcohols by Stabilization of Carboxonium Intermediates

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2031-2037
Author(s):  
Antonio Leyva-Pérez ◽  
María Tejeda-Serrano ◽  
Sergio Sanz-Navarro ◽  
Finn Blake
Keyword(s):  
Organic Synthesis ◽  
Butyl Acetate ◽  
Strong Acid ◽  
Organic Reactions ◽  
High Yield ◽  
Acid Catalysts ◽  
Nazarov Cyclization ◽  
Triflic Acid ◽  
Nazarov Reaction ◽  
Tert Butyl

Zeolites are the most used catalysts worldwide in petrochemistry processes, with particular ability to stabilize carbocations. However, the use of zeolites in organic synthesis is still scarce. We show here that representative carboxonium-mediated organic reactions, such as the Nazarov cyclization and the tert-butylation of alcohols with tert-butyl acetate, typically performed with very strong acid catalysts in solution such as triflic acid, can be catalyzed by simple zeolites with high yield and selectivity. The aluminosilicate framework stabilizes the intermediate carboxonium species and overrides the need for superacid protons in solution.

scholarly journals The chemistry of bisallenes

2012 ◽  
Vol 8 ◽  
pp. 1936-1998 ◽  
Author(s):  
Henning Hopf ◽  
Georgios Markopoulos
Keyword(s):  
Structural Properties ◽  
Organic Synthesis ◽  
High Yield ◽  
Cycloaddition Reactions ◽  
Atom Economy ◽  
Ring Systems ◽  
Target Molecules ◽  
Molecular Complexity ◽  
First Time

This review describes the preparation, structural properties and the use of bisallenes in organic synthesis for the first time. All classes of compounds containing at least two allene moieties are considered, starting from simple conjugated bisallenes and ending with allenes in which the two cumulenic units are connected by complex polycyclic ring systems, heteroatoms and/or heteroatom-containing tethers. Preparatively the bisallenes are especially useful in isomerization and cycloaddition reactions of all kinds leading to the respective target molecules with high atom economy and often in high yield. Bisallenes are hence substrates for generating molecular complexity in a small number of steps (high step economy).

scholarly journals Palladium-Catalyzed Cross-Coupling of Gem-Bromofluoroalkenes with Alkylboronic Acids for the Synthesis of Alkylated Monofluoroalkenes

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5532
Author(s):  
Laëtitia Chausset-Boissarie ◽  
Nicolas Cheval ◽  
Christian Rolando
Keyword(s):  
Organic Synthesis ◽  
Functional Group ◽  
Materials Science ◽  
Cross Coupling ◽  
High Yield ◽  
Efficient Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Palladium Catalyzed ◽  
Novel Strategy

Monofluoroalkenes are versatile fluorinated synthons in organic synthesis, medicinal chemistry and materials science. In light of the importance of alkyl-substituted monofluoroalkenes efficient synthesis of these moieties still represents a synthetic challenge. Herein, we described a mild and efficient methodology to obtain monofluoroalkenes through a stereospecific palladium-catalyzed alkylation of gem-bromofluoroalkenes with primary and strained secondary alkylboronic acids under mild conditions. This novel strategy gives access to a wide range of functionalized tri- and tetrasubstituted monofluoroalkenes in high yield, with good functional group tolerance, independently from the gem-bromofluoroalkenes geometry.

scholarly journals Investigating the effectiveness of classical and eco-friendly approaches for synthesis of dialdehydes from organic dihalides

2019 ◽  
Vol 8 (1) ◽  
pp. 635-648 ◽  
Author(s):  
Muhammad Faisal ◽  
Mukhtiar Ahmed ◽  
Sarwat Hussain ◽  
Fayaz Ali Larik ◽  
Aamer Saeed
Keyword(s):  
Hydrogen Peroxide ◽  
Organic Synthesis ◽  
Vanadium Pentoxide ◽  
Sodium Periodate ◽  
Periodic Acid ◽  
Research Work ◽  
High Yield ◽  
Synthetic Approach ◽  
Kornblum Oxidation ◽  
Excellent Selectivity

Abstract Monoaldehydes and dialdehydes are parts of millions of compounds and are extremely versatile intermediates. For the synthesis of monoaldehydes, one impressive approach to date, because of its excellent selectivity, high yield and stability towards over-oxidation and over-reduction, is the oxidation of organic monohalides. Numerous monohalides oxidation based methodologies to afford monoaldehydes are disclosed in literature. In this research work, twelve well-known approaches (well-documented for synthesis of monoaldehydes from monohalides) are investigated for their effectiveness towards synthesis of organic dialdehydes from organic dihalides. The classical approaches under investigation include modified Sommelet oxidation, Kröhnke oxidation, sodium periodate-mediated oxidative protocol, manganese dioxide-based oxidative approach, Kornblum oxidation and Hass-Bender oxidation. The eco-friendly approaches under observation include periodic acid-based IL protocol, periodic acid in vanadium pentoxide-mediated IL method, hydrogen peroxide in vanadium pentoxide-based approach, hydrogen peroxide-mediated IL methodology, IBX-assisted IL protocol and bismuth nitrate-promoted IL technique. In this investigation yield, overoxidation, eco-friendliness, cost-effectiveness and recyclability are the main parameters which are under examination. Hopefully, this research will help chemists in carrying out routine operations in organic synthesis and will also be fruitful to select finest synthetic approach, develop further new transformational methodologies and improve current transformational approaches for the synthesis of dialdehydes.

Practical approach to high-yield enzymic stereospecific organic synthesis in multiphase systems

1981 ◽  
Vol 46 (15) ◽  
pp. 3128-3131 ◽  
Author(s):  
Marie Jose De Smet ◽  
Bernard Witholt ◽  
Hans Wynberg
Keyword(s):  
Organic Synthesis ◽  
Practical Approach ◽  
High Yield ◽  
Multiphase Systems

Hydrogen bonding in organic synthesis IV: A simple, high-yield method for the methylenation of catechols

1976 ◽  
Vol 17 (38) ◽  
pp. 3361-3364 ◽  
Author(s):  
James H. Clark ◽  
Herbert L. Holland ◽  
Jack M. Miller
Keyword(s):  
Hydrogen Bonding ◽  
Organic Synthesis ◽  
High Yield
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