Use of carboxylic acids as chiral solvating agents for the determination of optical purity of chiral amines by NMR spectroscopy

1988 ◽  
Vol 53 (22) ◽  
pp. 5335-5341 ◽  
Author(s):  
Scott C. Benson ◽  
Ping Cai ◽  
Marcelo Colon ◽  
Mohammed A. Haiza ◽  
Maritherese Tokles ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Carboxylic Acids ◽  
Optical Purity ◽  
Chiral Amines

ChemInform Abstract: Use of Carboxylic Acids as Chiral Solvating Agents for the Determination of Optical Purity of Chiral Amines by NMR Spectroscopy.

ChemInform ◽  
1989 ◽  
Vol 20 (18) ◽  
Author(s):  
S. C. BENSON ◽  
P. CAI ◽  
M. COLON ◽  
M. A. HAIZA ◽  
M. TOKLES ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Carboxylic Acids ◽  
Optical Purity ◽  
Chiral Amines

Role of Barium(II) in the Determination of the Absolute Configuration of Chiral Amines by1H NMR Spectroscopy

2006 ◽  
Vol 71 (3) ◽  
pp. 1119-1130 ◽  
Author(s):  
Rosa García ◽  
José M. Seco ◽  
Saulo A. Vázquez ◽  
Emilio Quiñoá ◽  
Ricardo Riguera
Keyword(s):  
Nmr Spectroscopy ◽  
Absolute Configuration ◽  
Chiral Amines ◽  
The Absolute

Determination of Alcohols, Phenols, and Carboxylic Acids Using Phosphorus-31 NMR Spectroscopy

1986 ◽  
Vol 40 (3) ◽  
pp. 348-351 ◽  
Author(s):  
David E. Schiff ◽  
John G. Verkade ◽  
Robert M. Metzler ◽  
Thomas G. Squires ◽  
Clifford G. Venier
Keyword(s):  
Free Radical ◽  
Nmr Spectroscopy ◽  
Carboxylic Acids ◽  
Chemical Shifts ◽  
Relaxation Times ◽  
Oh Groups

Derivatization of compounds containing -OH groups can be accomplished quantitatively with 1,3,2-dioxaphospholanyl chloride. The chemical shifts of phosphorus in the derivatives clearly differentiate alcohols from phenols and carboxylic acids. Quantitation is obtained by use of 31P FT-NMR spectroscopy in the presence of 2,2,6,6-tetrameth-ylpiperidinyloxy free radical to shorten relaxation times. Compounds with phosphorus chemical shifts differing by as little as 0.1 ppm can be separately determined.

Enantiomeric NMR discrimination of carboxylic acids using actinomycin D as a chiral solvating agent

2019 ◽  
Vol 17 (6) ◽  
pp. 1466-1470 ◽  
Author(s):  
Liwen Bai ◽  
Pian Chen ◽  
Jiangxia Xiang ◽  
Jiarui Sun ◽  
Xinxiang Lei
Keyword(s):  
Nmr Spectroscopy ◽  
Carboxylic Acids ◽  
Actinomycin D ◽  
H Nmr ◽  
Chiral Solvating Agent

We extended actinomycin D as a practical CSA for rapid enantiomeric determination of chiral carboxylic acids by1H NMR spectroscopy.

Determination of the optical purity of some substituted N-phenylpropionamides by NMR spectroscopy

1973 ◽  
Vol 5 (9) ◽  
pp. 413-417 ◽  
Author(s):  
Günther Snatzke ◽  
John E. Fox ◽  
Mustafa M. El-Abadelah
Keyword(s):  
Nmr Spectroscopy ◽  
Optical Purity
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