A facile synthesis of statine and analogs by reduction of .beta.-keto esters derived from Boc-protected amino acids. HPLC analyses of their enantiomeric purity

1988 ◽  
Vol 53 (4) ◽  
pp. 869-873 ◽  
Author(s):  
Juergen Maibaum ◽  
Daniel H. Rich
Keyword(s):  
Amino Acids ◽  
Enantiomeric Purity ◽  
Facile Synthesis ◽  
Keto Esters ◽  
Hplc Analyses

Synthesis of β- and β,β-substituted Morita–Baylis–Hillman adducts using a two-step protocol

2012 ◽  
Vol 90 (5) ◽  
pp. 450-463 ◽  
Author(s):  
David I. Magee ◽  
Same Ratshonka ◽  
Jessica McConaghy ◽  
Maggie Hood
Keyword(s):  
Knoevenagel Condensation ◽  
Condensation Reaction ◽  
Facile Synthesis ◽  
Aliphatic Aldehydes ◽  
Tert Butyl ◽  
Keto Esters ◽  
Knoevenagel Condensation Reaction

The synthesis of a large number of β- and β,β-substituted keto esters was successful by the use of the Knoevenagel condensation reaction. The stereoselectivity of these reactions was improved by alteration of various substituent groups. Although there were few examples of complete Z selectivity, the use of tert-butyl acetoacetate with either aromatic or aliphatic aldehydes afforded Z selectivity. The selective reductions of these substituted keto esters was successfully achieved by using a combination of NaBH4 and CeCl3·7H2O or Yb(OTf)3, which allowed a facile synthesis of a large number of stereochemically pure substituted Morita–Baylis–Hillman adducts, including β,β-substituted adducts.

Facile synthesis of tert-butyl ester of N-protected amino acids with tert-butyl bromide

1993 ◽  
Vol 34 (46) ◽  
pp. 7409-7412 ◽  
Author(s):  
Pierre Chevallet ◽  
Patrick Garrouste ◽  
Barbara Malawska ◽  
Jean Martinez
Keyword(s):  
Amino Acids ◽  
Butyl Ester ◽  
Facile Synthesis ◽  
Butyl Bromide ◽  
Tert Butyl

Facile Synthesis of Aryl α-Keto Esters via the Reaction of Aryl Diazoacetate with H2O and DEAD.

ChemInform ◽  
2007 ◽  
Vol 38 (3) ◽  
Author(s):  
Zhenqiu Guo ◽  
Haoxi Huang ◽  
Qingquan Fu ◽  
Wenhao Hu
Keyword(s):  
Facile Synthesis ◽  
Keto Esters

Facile Synthesis of Completely Protected Enantiomerically Pure α,α-Disubstituted α-Amino Acids

Synlett ◽  
1996 ◽  
Vol 1996 (07) ◽  
pp. 665-666 ◽  
Author(s):  
Bernhard Westermann ◽  
Ina Gedrath
Keyword(s):  
Amino Acids ◽  
Facile Synthesis ◽  
Enantiomerically Pure

scholarly journals Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides

2017 ◽  
Vol 30 (5) ◽  
pp. 1704878 ◽  
Author(s):  
Simone A. Costa ◽  
Joseph R. Simon ◽  
Miriam Amiram ◽  
Lei Tang ◽  
Stefan Zauscher ◽  
...  
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
Facile Synthesis ◽  
Intrinsically Disordered
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