Stereochemistry of intramolecular amidoalkylation reactions in the synthesis of polycyclic isoquinoline derivatives

1983 ◽  
Vol 48 (25) ◽  
pp. 5062-5074 ◽  
Author(s):  
Bruce E. Maryanoff ◽  
David F. McComsey ◽  
Barbara A. Duhl-Emswiler
Keyword(s):  
Intramolecular Amidoalkylation ◽  
Isoquinoline Derivatives

Silver-Catalyzed Desulfurizative Annulation of 1,2-Benzisothiazoles with Ynamides to Construct Multi-Substituted Isoquinolines

2021 ◽  
Author(s):  
Rui Fu ◽  
Ran Liu ◽  
Kang Lv ◽  
Changlei Zhu ◽  
Xiaoguang Bao
Keyword(s):  
Isoquinoline Derivatives

An unprecedented silver-catalyzed desulfurizative annulation of 1,2-benzisothiazoles with ynamides is disclosed, which offers a concise protocol to access multi-substituted isoquinoline derivatives. Mechanistically, the chemo- and regio-selective N-attack of 1,2-benzisothiazoles to...

Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR

2012 ◽  
Vol 22 (9) ◽  
pp. 3305-3310 ◽  
Author(s):  
Rie Nishikawa-Shimono ◽  
Yoshinori Sekiguchi ◽  
Takeshi Koami ◽  
Madoka Kawamura ◽  
Daisuke Wakasugi ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Isoquinoline Derivatives
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