Semisynthetic pyrrolizidine alkaloid antitumor agents

1982 ◽  
Vol 47 (13) ◽  
pp. 2501-2504 ◽  
Author(s):  
Leslie T. Gelbaum ◽  
Maureen M. Gordon ◽  
Mark Miles ◽  
Leon H. Zalkow
Keyword(s):  
Antitumor Agents ◽  
Pyrrolizidine Alkaloid

Semisynthetic pyrrolizidine alkaloid N-oxide antitumor agents. Esters of heliotridine

1988 ◽  
Vol 31 (8) ◽  
pp. 1520-1526 ◽  
Author(s):  
Leon H. Zalkow ◽  
Jan A. Glinski ◽  
Leslie T. Gelbaum ◽  
David Moore ◽  
Deborah Melder ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Pyrrolizidine Alkaloid

ChemInform Abstract: SEMISYNTHETIC PYRROLIZIDINE ALKALOID ANTITUMOR AGENTS

1982 ◽  
Vol 13 (51) ◽  
Author(s):  
L. T. GELBAUM ◽  
M. M. GORDON ◽  
M. MILES ◽  
L. H. ZALKOW
Keyword(s):  
Antitumor Agents ◽  
Pyrrolizidine Alkaloid

Acute lung injury induced by the pyrrolizidine alkaloid monocrotaline in mice

Pneumologie ◽  
2006 ◽  
Vol 60 (S 1) ◽  
Author(s):  
R Dumitrascu ◽  
S Köbrich ◽  
H Traupe ◽  
E Dony ◽  
S Pullamsetti ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pyrrolizidine Alkaloid

Vitamin D as potential therapeutic anticancer agent

2018 ◽  
pp. 1-3
Keyword(s):  
Vitamin D ◽  
Anticancer Activity ◽  
Anticancer Agent ◽  
Antitumor Agents ◽  
Metastatic Potential ◽  
Anticancer Properties ◽  
Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

Oxazole: A Promising Building Block for the Development of Potent Antitumor Agents

2016 ◽  
Vol 16 (30) ◽  
pp. 3582-3589 ◽  
Author(s):  
Hua Zhou ◽  
Jiang-Qun Cheng ◽  
Zhi-Sen Wang ◽  
Fei-Hu Chen ◽  
Xin-Hua Liu
Keyword(s):  
Building Block ◽  
Antitumor Agents
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