Conformationally Restricted Peptide Mimetics: The Incorporation of 6,5-Bicyclic Lactam Ring Skeletons into Peptides

1995 ◽  
Vol 60 (25) ◽  
pp. 8155-8170 ◽  
Author(s):  
Wenhao Li ◽  
Cathleen E. Hanau ◽  
Andre dAvignon ◽  
Kevin D. Moeller
Keyword(s):  
Peptide Mimetics ◽  
Conformationally Restricted ◽  
Lactam Ring

ChemInform Abstract: Conformationally Restricted Peptide Mimetics by Ring-Closing Olefin Metathesis.

ChemInform ◽  
2012 ◽  
Vol 43 (51) ◽  
pp. no-no
Author(s):  
Satish Wakchaure ◽  
Juergen Einsiedel ◽  
Reiner Waibel ◽  
Peter Gmeiner
Keyword(s):  
Olefin Metathesis ◽  
Peptide Mimetics ◽  
Conformationally Restricted

3,8-Diazabicyclo[3.2.1]octan-2-one Peptide Mimetics:  Synthesis of a Conformationally Restricted Inhibitor of Farnesyltransferase†

2001 ◽  
Vol 3 (6) ◽  
pp. 865-868 ◽  
Author(s):  
Christopher J. Dinsmore ◽  
Jeffrey M. Bergman ◽  
Michael J. Bogusky ◽  
J. Christopher Culberson ◽  
Kelly A. Hamilton ◽  
...  
Keyword(s):  
Peptide Mimetics ◽  
Conformationally Restricted

Conformationally Restricted Peptide Mimetics by Ring-Closing Olefin Metathesis

Synthesis ◽  
2012 ◽  
Vol 44 (17) ◽  
pp. 2682-2694 ◽  
Author(s):  
Peter Gmeiner ◽  
Satish Wakchaure ◽  
Jürgen Einsiedel ◽  
Reiner Waibel
Keyword(s):  
Olefin Metathesis ◽  
Peptide Mimetics ◽  
Conformationally Restricted

Synthesis of 8-amino-3-oxoindolizidine-1-carboxylic acid derivatives as conformationally restricted templates for use in design of peptide mimetics

Tetrahedron ◽  
1995 ◽  
Vol 51 (9) ◽  
pp. 2729-2736 ◽  
Author(s):  
Isabel María Gómez Monterrey ◽  
Rosario González-Muñiz ◽  
Rosario Herranz ◽  
María Teresa García-López
Keyword(s):  
Carboxylic Acid ◽  
Peptide Mimetics ◽  
Conformationally Restricted

Development and Validation of an Eco-Friendly and Low-Cost Method for the Quantification of Cefepime Hydrochloride in Powder for Injectable Solution Using Infrared (IR) Spectroscopy

2020 ◽  
Vol 16 (4) ◽  
pp. 456-464
Author(s):  
Danilo F. Rodrigues ◽  
Hérida R.N. Salgado
Keyword(s):  
Ir Spectroscopy ◽  
Low Cost ◽  
Pharmaceutical Preparations ◽  
Potassium Bromide ◽  
Pharmaceutical Products ◽  
Injectable Formulation ◽  
Ich Guidelines ◽  
Lactam Ring ◽  
Development And Validation

Background: A simple, eco-friendly and low-cost Infrared (IR) method was developed and validated for the analysis of Cefepime Hydrochloride (CEF) in injectable formulation. Different from some other methods, which employ organic solvents in the analyses, this technique does not use these types of solvents, removing large impacts on the environment and risks to operators. Objective: This study aimed at developing and validating a green analytical method using IR spectroscopy for the determination of CEF in pharmaceutical preparations. Methods: The method was validated according to ICH guidelines and the quantification of CEF was performed in the spectral region absorbed at 1815-1745 cm-1 (stretching of the carbonyl group of β- lactam ring). Results: The validated method showed to be linear (r = 0.9999) in the range of 0.2 to 0.6 mg/pellet of potassium bromide, as well as for the parameters of selectivity, precision, accuracy, robustness and Limits of Detection (LOD) and Quantification (LOQ), being able to quantify the CEF in pharmaceutical preparations. The CEF content obtained by the IR method was 103.86%. Conclusion: Thus, the method developed may be an alternative in the quality control of CEF sample in lyophilized powder for injectable solution, as it presented important characteristics in the determination of the pharmaceutical products, with low analysis time and a decrease in the generation of toxic wastes to the environment.

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