A Concise, Practical Synthesis of the Pyrido[3,2,1-i,j]Cinnoline Ring System of Potent DNA Gyrase Inhibitors

1995 ◽  
Vol 60 (12) ◽  
pp. 3928-3930 ◽  
Author(s):  
David Barrett ◽  
Hiroshi Sasaki ◽  
Hideo Tsutsumi ◽  
Masayoshi Murata ◽  
Takeshi Terasawa ◽  
...  
Keyword(s):  
Dna Gyrase ◽  
Ring System ◽  
Practical Synthesis ◽  
Gyrase Inhibitors

ChemInform Abstract: A Concise, Practical Synthesis of the Pyrido(3.2.1-ij)cinnoline Ring System of Potent DNA Gyrase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 26 (46) ◽  
pp. no-no
Author(s):  
D. BARRETT ◽  
H. SASAKI ◽  
H. TSUTSUMI ◽  
M. MURATA ◽  
T. TERASAWA ◽  
...  
Keyword(s):  
Dna Gyrase ◽  
Ring System ◽  
Practical Synthesis ◽  
Gyrase Inhibitors

New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors

2017 ◽  
Vol 27 (5) ◽  
pp. 1162-1168 ◽  
Author(s):  
Hülya Karaca Gençer ◽  
Serkan Levent ◽  
Ulviye Acar Çevik ◽  
Yusuf Özkay ◽  
Sinem Ilgın
Keyword(s):  
Dna Gyrase ◽  
Gyrase Inhibitors

Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles

2005 ◽  
Vol 15 (19) ◽  
pp. 4299-4303 ◽  
Author(s):  
Akihiko Tanitame ◽  
Yoshihiro Oyamada ◽  
Keiko Ofuji ◽  
Hideo Terauchi ◽  
Motoji Kawasaki ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Dna Gyrase ◽  
Gyrase Inhibitors

Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4-Substituted Quinazoline Derivatives as DNA-Gyrase Inhibitors

2010 ◽  
Vol 343 (10) ◽  
pp. 570-576 ◽  
Author(s):  
Shireesha Boyapati ◽  
Umasankar Kulandaivelu ◽  
Srinivas Sangu ◽  
Malla Reddy Vanga
Keyword(s):  
Dna Gyrase ◽  
Docking Studies ◽  
Antimicrobial Evaluation ◽  
Quinazoline Derivatives ◽  
Gyrase Inhibitors

scholarly journals Synthesis, Characterization and in vitro Antimicrobial Evaluation of Chalconeimine Derivatives as Potential Inhibitors against Enzymes Produced from S. aureus: A Computational Approach

2019 ◽  
Vol 31 (10) ◽  
pp. 2157-2164
Author(s):  
B. Prithivirajan ◽  
M. Jebastin Sonia Jas ◽  
G. Marimuthu
Keyword(s):  
Antibacterial Agents ◽  
Dna Gyrase ◽  
Bacterial Strains ◽  
Bacterial Proteins ◽  
Antibiotic Drug ◽  
In Vitro Antibacterial Activity ◽  
Antimicrobial Evaluation ◽  
Potential Inhibitors ◽  
Gyrase Inhibitors

(Z)-1-(Benzo[d][1,3]dioxol-5-yl)-3-(4-(difluoromethoxy)-3-hydroxyphenyl)prop-2-en-1-one hydrazone derivatives pronounced in this manuscript represents a new collection of antibacterial agents in addition to the DNA gyrase inhibitors. Efforts had been made to synthesize those chalcone-hydrazone derivatives (4a-e) in good yields. The literature survey confirms that nano-ZnO as heterogeneous catalyst has obtained big interest because of its ecofriendly nature and has been explored as a effective catalyst for several organic ameliorations. Subsequently, induced by way of these observations and in continuation to our interest in organic synthesis with using nanocatalyst. in vitro Antibacterial activity has been evaluated towards Gram-positive and Gram-negative bacterial strains for all compounds. So one can discover the affinity to bacterial proteins docking have a look at have been carried out for 5 synthesized derivatives, antibiotic drug and co-crystallized ligands with special mechanism of action DNA gyrase B and methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) the usage of AutoDock 4.

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