Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4-Substituted Quinazoline Derivatives as DNA-Gyrase Inhibitors

2010 ◽  
Vol 343 (10) ◽  
pp. 570-576 ◽  
Author(s):  
Shireesha Boyapati ◽  
Umasankar Kulandaivelu ◽  
Srinivas Sangu ◽  
Malla Reddy Vanga
Keyword(s):  
Dna Gyrase ◽  
Docking Studies ◽  
Antimicrobial Evaluation ◽  
Quinazoline Derivatives ◽  
Gyrase Inhibitors

Novel 2-arylbenzothiazole DNA gyrase inhibitors: Synthesis, antimicrobial evaluation, QSAR and molecular docking studies

2019 ◽  
Vol 93 ◽  
pp. 103373 ◽  
Author(s):  
Iman A.Y. Ghannam ◽  
Eman A. Abd El-Meguid ◽  
Islam H. Ali ◽  
Donia H. Sheir ◽  
Ahmed M. El Kerdawy
Keyword(s):  
Molecular Docking ◽  
Dna Gyrase ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Antimicrobial Evaluation ◽  
Gyrase Inhibitors

scholarly journals Synthesis, Characterization and in vitro Antimicrobial Evaluation of Chalconeimine Derivatives as Potential Inhibitors against Enzymes Produced from S. aureus: A Computational Approach

2019 ◽  
Vol 31 (10) ◽  
pp. 2157-2164
Author(s):  
B. Prithivirajan ◽  
M. Jebastin Sonia Jas ◽  
G. Marimuthu
Keyword(s):  
Antibacterial Agents ◽  
Dna Gyrase ◽  
Bacterial Strains ◽  
Bacterial Proteins ◽  
Antibiotic Drug ◽  
In Vitro Antibacterial Activity ◽  
Antimicrobial Evaluation ◽  
Potential Inhibitors ◽  
Gyrase Inhibitors

(Z)-1-(Benzo[d][1,3]dioxol-5-yl)-3-(4-(difluoromethoxy)-3-hydroxyphenyl)prop-2-en-1-one hydrazone derivatives pronounced in this manuscript represents a new collection of antibacterial agents in addition to the DNA gyrase inhibitors. Efforts had been made to synthesize those chalcone-hydrazone derivatives (4a-e) in good yields. The literature survey confirms that nano-ZnO as heterogeneous catalyst has obtained big interest because of its ecofriendly nature and has been explored as a effective catalyst for several organic ameliorations. Subsequently, induced by way of these observations and in continuation to our interest in organic synthesis with using nanocatalyst. in vitro Antibacterial activity has been evaluated towards Gram-positive and Gram-negative bacterial strains for all compounds. So one can discover the affinity to bacterial proteins docking have a look at have been carried out for 5 synthesized derivatives, antibiotic drug and co-crystallized ligands with special mechanism of action DNA gyrase B and methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) the usage of AutoDock 4.

Synthesis, docking, QSAR, ADMET and antimicrobial evaluation of new quinoline-3-carbonitrile derivatives as potential DNA-gyrase inhibitors

2018 ◽  
Vol 1166 ◽  
pp. 15-33 ◽  
Author(s):  
Kamal M. El-Gamal ◽  
Ahmed M. El-Morsy ◽  
Ahmad M. Saad ◽  
Ibrahim H. Eissa ◽  
Mohamed Alswah
Keyword(s):  
Dna Gyrase ◽  
Antimicrobial Evaluation ◽  
Gyrase Inhibitors

Esterprodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies

MedChemComm ◽  
2011 ◽  
Vol 2 (5) ◽  
pp. 430-435 ◽  
Author(s):  
Faustine Dubar ◽  
René Wintjens ◽  
Érica S. Martins-Duarte ◽  
Rossiane C. Vommaro ◽  
Wanderley de Souza ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Molecular Modeling ◽  
Toxoplasma Gondii ◽  
Dna Gyrase ◽  
Docking Studies ◽  
Mechanisms Of Action ◽  
Computational Calculations ◽  
Gyrase Inhibitors ◽  
Ester Prodrugs

Novel ester prodrugs of ciprofloxacin proved to be extremely efficient against Plasmodium falciparum and Toxoplasma gondii. Molecular modeling and computational calculations were used to understand the mechanisms of action of these drugs.

scholarly journals Synthesis, Characterization, Antibacterial Evaluation and Molecular Docking Studies of 2-Azetidinone Derivatives as Novel DNA Gyrase Inhibitors

2015 ◽  
Vol 47 ◽  
pp. 94-108 ◽  
Author(s):  
R. Munavar Sulthana ◽  
S. Darlin Quine
Keyword(s):  
Streptococcus Pyogenes ◽  
Dna Gyrase ◽  
Docking Study ◽  
Spectroscopic Studies ◽  
Docking Studies ◽  
Diffusion Method ◽  
Zone Of Inhibition ◽  
Target Dna ◽  
Gyrase Inhibitors ◽  
Antibacterial Evaluation

Newly designed 2-azetidinone derivatives (4a-e) were synthesized in good yields and characterised by advanced spectroscopic studies. The title compounds were evaluated for qualitative (zone of inhibition) by agar diffusion method against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Streptococcus pyogenes. Some of the analogues were found to have comparable or even more potency than the standard drugs. Docking study was performed to check interaction of synthesized compounds with the target DNA gyrase.

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