Reaction of dianions of acyclic .beta.-enamino ketones with electrophiles. 3. Nitriles: synthesis of pyridine and pyrimidine derivatives

1992 ◽  
Vol 57 (22) ◽  
pp. 6020-6025 ◽  
Author(s):  
Giuseppe Bartoli ◽  
Marcella Bosco ◽  
Cristina Cimarelli ◽  
Renato Dalpozzo ◽  
Giovanni De Munno ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
Enamino Ketones ◽  
Pyridine And Pyrimidine Derivatives

scholarly journals A Proline and 4‐Hydroxyproline Based Approach to Enantiopure Pyrrolidin‐2‐yl‐Substituted Pyridine and Pyrimidine Derivatives

2021 ◽  
Author(s):  
Benjamin Brennecke ◽  
Alicia Castelló Micó ◽  
Lars Selter ◽  
Matteo Accorsi ◽  
Reinhold Zimmer ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
Pyridine And Pyrimidine Derivatives

ChemInform Abstract: Synthesis of Some New Pyridine and Pyrimidine Derivatives Containing Benzothiazole Moiety.

ChemInform ◽  
2013 ◽  
Vol 44 (47) ◽  
pp. no-no
Author(s):  
Khaled S. Mohamed ◽  
Nayra M. Abdulaziz ◽  
Ahmed A. Fadda
Keyword(s):  
Pyrimidine Derivatives ◽  
Pyridine And Pyrimidine Derivatives

scholarly journals Fluorescent property of 3-hydroxymethyl imidazo[1,2-a]pyridine and pyrimidine derivatives

2012 ◽  
Vol 6 (1) ◽  
Author(s):  
Stephania Velázquez-Olvera ◽  
Héctor Salgado-Zamora ◽  
Manuel Velázquez-Ponce ◽  
Elena Campos-Aldrete ◽  
Alicia Reyes-Arellano ◽  
...  
Keyword(s):  
Fluorescent Property ◽  
Pyrimidine Derivatives ◽  
Pyridine And Pyrimidine Derivatives

scholarly journals The Flögel-three-component reaction with dicarboxylic acids – an approach to bis(β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and pyrimidine derivatives

2014 ◽  
Vol 10 ◽  
pp. 394-404 ◽  
Author(s):  
Mrinal K Bera ◽  
Moisés Domínguez ◽  
Paul Hommes ◽  
Hans-Ulrich Reissig
Keyword(s):  
Dft Calculations ◽  
Carboxylic Acids ◽  
Aromatic Compounds ◽  
Dicarboxylic Acids ◽  
Membered Ring ◽  
Simple Synthesis ◽  
Pyrimidine Derivatives ◽  
Three Component Reaction ◽  
Palladium Catalyzed ◽  
Pyridine And Pyrimidine Derivatives

An extension of the substrate scope of the Flögel-three-component reaction of lithiated alkoxyallenes, nitriles and carboxylic acids is presented. The use of dicarboxylic acids allowed the preparation of symmetrical bis(β-ketoenamides) from simple starting materials in moderate yields. Cyclocondensations of these enamides to 4-hydroxypyridine derivatives or to functionalized pyrimidines efficiently provided symmetrically and unsymmetrically substituted fairly complex (hetero)aromatic compounds containing up to six conjugated aryl and hetaryl groups. In addition, subsequent functionalizations of the obtained heterocycles by palladium-catalyzed couplings or by oxidations are reported. We also describe the simple synthesis of a structurally interesting macrocyclic bispyrimidine derivative incorporating a 17-membered ring, whose configuration was elucidated by DFT calculations and by subsequent reactions.

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