Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease:  Structure-Based Design, Synthesis, and Biological Evaluation

Siegfried H. Reich; Theodore Johnson; Michael B. Wallace; Susan E. Kephart; Shella A. Fuhrman; Stephen T. Worland; David A. Matthews; Thomas F. Hendrickson; Fora Chan; James Meador; Rose Ann Ferre; Edward L. Brown; Dorothy M. DeLisle; Amy K. Patick; Susan L. Binford; Clifford E. Ford

doi:10.1021/jm9903242

Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease: Structure-Based Design, Synthesis, and Biological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/jm9903242 ◽

2000 ◽

Vol 43 (9) ◽

pp. 1670-1683 ◽

Cited By ~ 32

Author(s):

Siegfried H. Reich ◽

Theodore Johnson ◽

Michael B. Wallace ◽

Susan E. Kephart ◽

Shella A. Fuhrman ◽

...

Keyword(s):

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Substituted Benzamide ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease: Structure-Based Design, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.200030078 ◽

2010 ◽

Vol 31 (30) ◽

pp. no-no

Author(s):

Siegfried H. Reich ◽

et al. et al.

Keyword(s):

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Substituted Benzamide ◽

Synthesis And Biological Evaluation

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies

Journal of Medicinal Chemistry ◽

10.1021/jm9800696 ◽

1998 ◽

Vol 41 (15) ◽

pp. 2819-2834 ◽

Cited By ~ 49

Author(s):

Peter S. Dragovich ◽

Stephen E. Webber ◽

Robert E. Babine ◽

Shella A. Fuhrman ◽

Amy K. Patick ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Peptide Structure ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics

Journal of Medicinal Chemistry ◽

10.1021/jm030166l ◽

2003 ◽

Vol 46 (21) ◽

pp. 4572-4585 ◽

Cited By ~ 66

Author(s):

Peter S. Dragovich ◽

Thomas J. Prins ◽

Ru Zhou ◽

Theodore O. Johnson ◽

Ye Hua ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Orally Bioavailable ◽

Synthesis And Biological Evaluation

Download Full-text

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure−Activity Studies of Ketomethylene-Containing Peptidomimetics

Journal of Medicinal Chemistry ◽

10.1021/jm980537b ◽

1999 ◽

Vol 42 (7) ◽

pp. 1203-1212 ◽

Cited By ~ 40

Author(s):

Peter S. Dragovich ◽

Thomas J. Prins ◽

Ru Zhou ◽

Shella A. Fuhrman ◽

Amy K. Patick ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7. Structure-Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics.

ChemInform ◽

10.1002/chin.200224205 ◽

2010 ◽

Vol 33 (24) ◽

pp. no-no

Author(s):

Peter S. Dragovich ◽

et al. et al.

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Abstract Structure ◽

Synthesis And Biological Evaluation

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1Lactam Moieties asl-Glutamine Replacements

Journal of Medicinal Chemistry ◽

10.1021/jm9805384 ◽

1999 ◽

Vol 42 (7) ◽

pp. 1213-1224 ◽

Cited By ~ 98

Author(s):

Peter S. Dragovich ◽

Thomas J. Prins ◽

Ru Zhou ◽

Stephen E. Webber ◽

Joseph T. Marakovits ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Synthesis And Biological Evaluation

Download Full-text

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics

Journal of Medicinal Chemistry ◽

10.1021/jm010469k ◽

2002 ◽

Vol 45 (8) ◽

pp. 1607-1623 ◽

Cited By ~ 88

Author(s):

Peter S. Dragovich ◽

Thomas J. Prins ◽

Ru Zhou ◽

Edward L. Brown ◽

Fausto C. Maldonado ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Orally Bioavailable ◽

Synthesis And Biological Evaluation

Download Full-text

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00008-2 ◽

2002 ◽

Vol 12 (5) ◽

pp. 733-738 ◽

Cited By ~ 51

Author(s):

Peter S. Dragovich ◽

Thomas J. Prins ◽

Ru Zhou ◽

Theodore O. Johnson ◽

Edward L. Brown ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies

Journal of Medicinal Chemistry ◽

10.1021/jm980068d ◽

1998 ◽

Vol 41 (15) ◽

pp. 2806-2818 ◽

Cited By ~ 63

Author(s):

Peter S. Dragovich ◽

Stephen E. Webber ◽

Robert E. Babine ◽

Shella A. Fuhrman ◽

Amy K. Patick ◽

...

Keyword(s):

Protease Inhibitors ◽

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

3C Protease ◽

Structure Activity ◽

Michael Acceptor ◽

Synthesis And Biological Evaluation

Download Full-text

Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.12.001 ◽

2011 ◽

Vol 21 (3) ◽

pp. 1057-1059 ◽

Cited By ~ 5

Author(s):

Hongliang Wang ◽

Junhai Xiao ◽

Dapeng Gao ◽

Xian Zhang ◽

Hui Yan ◽

...

Keyword(s):

Biological Evaluation ◽

Human Rhinovirus ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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