Synthesis of 1-Substituted 3-(Chloromethyl)-6-aminoindoline (6-Amino-seco-CI) DNA Minor Groove Alkylating Agents and Structure−Activity Relationships for Their Cytotoxicity

Jared B. J. Milbank; Moana Tercel; Graham J. Atwell; William R. Wilson; Alison Hogg; William A. Denny

doi:10.1021/jm980545s

Synthesis of 1-Substituted 3-(Chloromethyl)-6-aminoindoline (6-Amino-seco-CI) DNA Minor Groove Alkylating Agents and Structure−Activity Relationships for Their Cytotoxicity

Journal of Medicinal Chemistry ◽

10.1021/jm980545s ◽

1999 ◽

Vol 42 (4) ◽

pp. 649-658 ◽

Cited By ~ 27

Author(s):

Jared B. J. Milbank ◽

Moana Tercel ◽

Graham J. Atwell ◽

William R. Wilson ◽

Alison Hogg ◽

...

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Dna Minor Groove ◽

Structure Activity Relationships ◽

Structure Activity

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Structure−Activity Relationships for 4-Nitrobenzyl Carbamates of 5-Aminobenz[e]indoline Minor Groove Alkylating Agents as Prodrugs for GDEPT in Conjunction withE.coliNitroreductase

Journal of Medicinal Chemistry ◽

10.1021/jm0205191 ◽

2003 ◽

Vol 46 (12) ◽

pp. 2456-2466 ◽

Cited By ~ 22

Author(s):

Michael P. Hay ◽

Graham J. Atwell ◽

William R. Wilson ◽

Susan M. Pullen ◽

William A. Denny

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Structure Activity Relationships ◽

Structure Activity

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Antimitotic Antitumor Agents: Synthesis, Structure−Activity Relationships, and Biological Characterization ofN-Aryl-N‘-(2-chloroethyl)ureas as New Selective Alkylating Agents

Journal of Medicinal Chemistry ◽

10.1021/jm0010264 ◽

2001 ◽

Vol 44 (5) ◽

pp. 694-702 ◽

Cited By ~ 53

Author(s):

Emmanuelle Mounetou ◽

Jean Legault ◽

Jacques Lacroix ◽

René C-Gaudreault

Keyword(s):

Antitumor Agents ◽

Alkylating Agents ◽

Biological Characterization ◽

Structure Activity Relationships ◽

Structure Activity

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DNA-Directed Alkylating Agents. 6. Synthesis and Antitumor Activity of DNA Minor Groove-Targeted Aniline Mustard Analogs of Pibenzimol (Hoechst 33258)

Journal of Medicinal Chemistry ◽

10.1021/jm00051a010 ◽

1994 ◽

Vol 37 (25) ◽

pp. 4338-4345 ◽

Cited By ~ 108

Author(s):

G. Lance Gravatt ◽

Bruce C. Baguley ◽

William R. Wilson ◽

William A. Denny

Keyword(s):

Antitumor Activity ◽

Alkylating Agents ◽

Minor Groove ◽

Hoechst 33258 ◽

Dna Minor Groove

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DNA Minor Groove Alkylating Agents

Current Medicinal Chemistry ◽

10.2174/0929867003373283 ◽

2001 ◽

Vol 8 (5) ◽

pp. 533-544 ◽

Cited By ~ 79

Author(s):

William A. Denny

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Dna Minor Groove

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Hematopoietic toxicity and cell cycle perturbations induced by new DNA minor groove–alkylating agents

International Journal of Cancer ◽

10.1002/(sici)1097-0215(19970904)72:5<801::aid-ijc16>3.0.co;2-b ◽

1997 ◽

Vol 72 (5) ◽

pp. 801-809 ◽

Cited By ~ 3

Author(s):

Cristian Filippini ◽

Matteo Bisiach ◽

Giovanna Tagliabue ◽

Maurizio D'Incalci ◽

Paolo Ubezio

Keyword(s):

Cell Cycle ◽

Alkylating Agents ◽

Minor Groove ◽

Dna Minor Groove ◽

Hematopoietic Toxicity

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ChemInform Abstract: Heterocyclic Analogues of DNA Minor Groove Alkylating Agents

ChemInform ◽

10.1002/chin.199835329 ◽

2010 ◽

Vol 29 (35) ◽

pp. no-no

Author(s):

P. G. BARALDI ◽

B. CACCIARI ◽

A. GUIOTTO ◽

R. ROMAGNOLI ◽

A. N. ZAID ◽

...

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Dna Minor Groove

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ChemInform Abstract: Antimitotic Antitumor Agents: Synthesis, Structure-Activity Relationships, and Biological Characterization of N-Aryl-N′-(2-chloroethyl)ureas as New Selective Alkylating Agents.

ChemInform ◽

10.1002/chin.200125095 ◽

2010 ◽

Vol 32 (25) ◽

pp. no-no

Author(s):

Emmanuelle Mounetou ◽

Jean Legault ◽

Jacques Lacroix ◽

Rene C-Gaudreault

Keyword(s):

Antitumor Agents ◽

Alkylating Agents ◽

Biological Characterization ◽

Structure Activity Relationships ◽

Structure Activity

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DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard

Journal of Medicinal Chemistry ◽

10.1021/jm00166a015 ◽

1990 ◽

Vol 33 (4) ◽

pp. 1177-1186 ◽

Cited By ~ 54

Author(s):

Trudi A. Gourdie ◽

Kisione K. Valu ◽

G. Lance Gravatt ◽

Theodore J. Boritzki ◽

Bruce C. Baguley ◽

...

Keyword(s):

Alkylating Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Distamycin A as Stem of DNA Minor Groove Alkylating Agents

Current Topics in Medicinal Chemistry ◽

10.2174/1568026043451474 ◽

2004 ◽

Vol 4 (2) ◽

pp. 231-239 ◽

Cited By ~ 10

Author(s):

Pier Baraldi ◽

Maria del Carmen Nunez ◽

Antonio Espinosa ◽

Romeo Romagnoli

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Distamycin A ◽

Dna Minor Groove

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DNA-Directed Alkylating Agents. 6. Synthesis and Antitumor Activity of DNA Minor Groove-Targeted Aniline Mustard Analogs of Pibenzimol. [Erratum to document cited in CA121:300815]

Journal of Medicinal Chemistry ◽

10.1021/jm00011a022 ◽

1995 ◽

Vol 38 (11) ◽

pp. 2022-2022 ◽

Cited By ~ 1

Author(s):

G. Lancer Gravatt ◽

Bruce C. Baguley ◽

William R. Wilson ◽

William A. Denny

Keyword(s):

Antitumor Activity ◽

Alkylating Agents ◽

Minor Groove ◽

Dna Minor Groove

Download Full-text