Second Supplements to the Second Edition ofRodd'sChemistryofCarbonCompounds. Volume IV:  Heterocyclic Compounds. Part C:  Five-Membered Heterocyclic Compounds with Two Hetero-Atoms in the Ring from Groups V and VI of the Periodic Table; Part D:  Five-Membered Heterocyclic Compounds with More Than Two Hetero-Atoms in the Ring Edited by M. Sainsbury. Elsevier, Amsterdam. 1998. xvi + 281 pp. 15.5 × 23 cm. ISBN-0-444-828702. $187.00.

1998 ◽  
Vol 41 (22) ◽  
pp. 4424-4424
Author(s):  
Arnold Martin
Keyword(s):  
Periodic Table ◽  
Heterocyclic Compounds ◽  
Part D ◽  
Part C

CheckMate 8KX: Phase 1/2 multitumor preliminary analyses of a subcutaneous formulation of nivolumab (± rHuPH20).

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 2575-2575
Author(s):  
Sara Lonardi ◽  
Iwona Lugowska ◽  
Christopher G. C. A. Jackson ◽  
Anne O'Donnell ◽  
Rastilav Bahleda ◽  
...  
Keyword(s):  
De Novo ◽  
Phase 1 ◽  
Geometric Mean ◽  
Primary Objective ◽  
Tumor Type ◽  
Part D ◽  
Part C ◽  
Local Site ◽  
Survival Expectations ◽  
Grade 3

2575 Background: Immunotherapy has transformed cancer survival expectations. Nivolumab (NIVO), a programmed death-1 inhibitor, is approved for intravenous (IV) administration across multiple cancers. BMS is developing a subcutaneous (SC) NIVO formulation with a permeation enhancer, recombinant human hyaluronidase PH20 enzyme (rHuPH20), to allow for more rapid delivery and the potential to decrease treatment burden. We report the first data on pharmacokinetics (PK), pharmacodynamics, safety, and immunogenicity for SC NIVO + rHuPH20. Methods: CheckMate 8KX is a phase 1/2 study in checkpoint inhibitor-naïve patients (pts) who were ≥ 18 years of age, ECOG PS 0–1, with metastatic/unresectable solid tumors and measurable disease. The primary objective was to describe SC NIVO PK; secondary objectives were safety and immunogenicity. Additional analyses compared exposures to historical IV NIVO (Zhao X, et al. J Clin Oncol 2020;31:302–309). In cycle 1, pts in Part A received SC NIVO 720 mg + rHuPH20, and pts in Part B received SC NIVO 720 mg, SC NIVO 960 mg + rHuPH20, or SC NIVO 960 mg. For cycles 2+, pts in Parts A and B received IV NIVO 480 mg every 4 weeks (Q4W). Pts still on study switched to Part C, SC NIVO 1200 mg + rHuPH20 until end of therapy. In Part D, pts received de novo SC NIVO 1200 mg + rHuPH20 Q4W. Results: Patient characteristics varied by age, weight, tumor type, and prior treatment. NIVO exposures increased with increasing SC dose (Table). For 960 mg and 1200 mg NIVO + rHuPH20, Cavg and Ctau were above geometric mean exposures for IV NIVO 3 mg/kg every 2 weeks (Q2W), and Cmax was below IV NIVO 10 mg/kg Q2W. In Part C (n = 28), 13 (46.4%) pts experienced any-grade TRAEs with no new/worsening grade 3+ TRAEs or TRAEs leading to discontinuation/death; 7 (25.0%) reported grade 1 local site reactions. In Part D (n = 36), 27 (75.0%) pts experienced any-grade TRAEs, 4 (11.1%) grade 3/4 TRAEs, 2 (5.6%) serious grade 3/4 TRAEs with 1 leading to discontinuation, and no treatment-related deaths; 10 (27.8%) reported grade 1 local site reactions. Anti-NIVO antibodies (Ab) were observed with SC NIVO but not associated with altered PK/safety, or neutralizing Ab. Exploratory biomarker data found increased CD8+ tumor-infiltrating lymphocytes and PD-L1 tumor expression in post-treatment biopsies, similar to IV NIVO. Conclusions: Exposures associated with SC NIVO + rHuPH20 doses investigated in CheckMate 8KX were well tolerated, with a safety profile consistent with IV NIVO. Data support evaluation of SC NIVO + rHuPH20 in a phase 3 study. Clinical trial information: NCT03656718. [Table: see text]

The Right to an Effective Remedy Pursuant to Article II-107 Paragraph 1 of the Constitutional Treaty

2005 ◽  
Vol 6 (11) ◽  
pp. 1601-1616
Author(s):  
Katharina Pabel
Keyword(s):  
European Union ◽  
Legal Protection ◽  
The European Union ◽  
Constitutional Treaty ◽  
Part D ◽  
Binding Effect ◽  
Part C ◽  
Effective Remedy ◽  
The Right

The fundamental right to an effective remedy as guaranteed in Art. II-107(1) of the ‘Treaty establishing a Constitution for Europe’ (CT) is part of a comprehensive guarantee of effective legal protection and procedural guarantees. In the following, this fundamental right and how it relates to Parts I and III of the CT will be investigated in detail. First, the scope of Art. II-107(1) CT will be identified in Part B. Part C comments on the binding effect of this right. Finally, in Part D, some aspects of the Union's system of legal protection will be investigated in the light of Art. II-107(1) CT, and it will be discussed whether this right could be an instrument to close gaps in the legal protection of individuals against measures of the European Union.

scholarly journals A New Chinese Economic Order?

2020 ◽  
Vol 23 (3) ◽  
pp. 607-635
Author(s):  
Gregory Shaffer ◽  
Henry Gao
Keyword(s):  
Innovation Policy ◽  
Legal Order ◽  
Development Model ◽  
Part D ◽  
Part C ◽  
Indigenous Innovation ◽  
Chinese State ◽  
Investment Agreements ◽  
Decentralized Model ◽  
Trade And Investment

ABSTRACT China is incrementally developing a new, decentralized model of trade governance through a web of finance, trade, and investment initiatives involving memorandum of understanding, contracts, and trade and investment treaties, supported by an indigenous innovation policy that is transnational in its reach. In this way, China could create a vast, Sino-centric, legal order in which the Chinese state plays the nodal role. It is a hub and spokes model, with China at the hub. In this article, we first examine China’s export of an infrastructure-based development model, implemented through Chinese state-owned and private enterprise investments and commercial contracts (Part B), before turning to China’s development of a complementary web of free trade and investment agreements (Part C), and an indigenous innovation policy (Part D). The paper theorizes and empirically traces how these Chinese initiatives shape the evolving ecology of the transnational legal order for trade.

scholarly journals The Readiness of Typical Student in Communication By Using Sign Language in Hearing Impairment Integration Programe

2018 ◽  
Vol 2 (1) ◽  
pp. 31
Author(s):  
Mohd Hanafi Mohd Yasin ◽  
Liong Kon Thai ◽  
Nuur Thaqifah Mohd Tahir
Keyword(s):  
Special Education ◽  
Secondary School ◽  
Sign Language ◽  
Hearing Impairment ◽  
Positive Relationship ◽  
Descriptive Analysis ◽  
Communication Medium ◽  
Part D ◽  
Part C ◽  
Language Class

<p>This research is regarding the readiness of typical student in communication by using sign language in Hearing Impairment Integration Programme. There were 60 typical students from a Special Education Integration Programme of secondary school in Malacca were chosen as research respondents. The instrument of the research was a set of questionnaire which consisted of four parts, namely Student’s demography (Part A), Student’s knowledge (Part B), Student’s ability to communicate (Part C) and Student’s interest to communicate (Part D). The questionnaire was adapted from the research of Asnul Dahar and Rabiah's 'The Readiness of Students in Following Vocational Subjects at Jerantut District, Rural Secondary School in Pahang'.  Descriptive analysis was used to analysis the data. Mean score was used to determine the level of respondents' perception of each question. The findings showed a positive relationship between typical students towards communication medium by using sign language. Typical students were seen to be interested in communicating using sign language and were willing to attend the Sign Language class if offered.</p>

scholarly journals The Influence of Online Media on Muslim Radicalism Among Senior High School Students

Afkaruna ◽  
2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Iqbal Miftakhul Mujtahid ◽  
Rian Vebrianto ◽  
Musa Thahir ◽  
Nelly Yusro
Keyword(s):  
High School ◽  
High School Students ◽  
Islamic Law ◽  
Female Students ◽  
Senior High School ◽  
School Students ◽  
Part D ◽  
Part C ◽  
Information And Communication ◽  
Senior High School Students

The analysis of radicalism attitudes among students is triggered by the lack of supervision of information and communication technology usage. This study aims to find the attitude of radicalism among senior high school students based on gender. The research is designed with a quantitative approach. The data were collected using a questionnaire. This study involved 229 students selected by random sampling, with a total of 107 male and 122 female students. The data were collected using a questionnaire and essay. The data were further analysed qualitatively and quantitatively. The results of this study showed that in Part A, 34% male and 19% female students often sent and shared religious content and conflicts on social media. In Part B, 13% male and 14% female students agreed on courtship, marriages with different religion, polygamy, and divorce. In Part C, 2% male and female students are anti-ideological and uphold Islamic law. Furthermore, in Part D, 67% male and 46% female students declare non-Muslims as infidel, and war is a part of jihad.

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