Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase

Surya K. De; John L. Stebbins; Li-Hsing Chen; Megan Riel-Mehan; Thomas Machleidt; Russell Dahl; Hongbin Yuan; Aras Emdadi; Elisa Barile; Vida Chen; Ria Murphy; Maurizio Pellecchia

doi:10.1021/jm801503n

Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase

Journal of Medicinal Chemistry ◽

10.1021/jm801503n ◽

2009 ◽

Vol 52 (7) ◽

pp. 1943-1952 ◽

Cited By ~ 43

Author(s):

Surya K. De ◽

John L. Stebbins ◽

Li-Hsing Chen ◽

Megan Riel-Mehan ◽

Thomas Machleidt ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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Design, Synthesis, and Structure–Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.7b00153 ◽

2017 ◽

Vol 8 (9) ◽

pp. 1980-1994 ◽

Cited By ~ 12

Author(s):

Wenfeng Lu ◽

Yongqiang Liu ◽

Haikuo Ma ◽

Jiyue Zheng ◽

Sheng Tian ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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STRUCTURE-ACTIVITY RELATIONSHIP OF VARIOUS ANALOGUES OF β-CORTICOTRROPHIN DETERMINED BY REFERENCE TO VARIOUS PARAMETERS IN VITRO AND IN VIVO

Acta Endocrinologica ◽

10.1530/acta.0.061s029 ◽

1969 ◽

Vol 61 (1_Suppl) ◽

pp. S29

Author(s):

Pierre A. Desaulles ◽

René Maier ◽

Matthys Staehelin

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.09.005 ◽

2008 ◽

Vol 18 (20) ◽

pp. 5533-5536 ◽

Cited By ~ 11

Author(s):

Synèse Jolidon ◽

Daniela Alberati ◽

Adam Dowle ◽

Holger Fischer ◽

Dominik Hainzl ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.07.092 ◽

2009 ◽

Vol 19 (17) ◽

pp. 4920-4923 ◽

Cited By ~ 32

Author(s):

Anh P. Truong ◽

Danielle L. Aubele ◽

Gary D. Probst ◽

Martin L. Neitzel ◽

Chris M. Semko ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationship of Novel Dinucleotide Analogues as Agents Against Herpes and Human Immunodeficiency Viruses.

ChemInform ◽

10.1002/chin.199611278 ◽

2010 ◽

Vol 27 (11) ◽

pp. no-no

Author(s):

G. H. HAKIMELAHI ◽

A. A. MOOSAVI-MOVAHEDI ◽

M. M. SADEGHI ◽

S.-C. TSAY ◽

J. R. HWU

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Human Immunodeficiency Viruses ◽

Relationship Of

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Design, Synthesis, and Structure–Activity Relationship of New Pyrimidinamine Derivatives Containing an Aryloxy Pyridine Moiety

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.6b05580 ◽

2017 ◽

Vol 65 (6) ◽

pp. 1272-1280 ◽

Cited By ~ 18

Author(s):

Aiying Guan ◽

Changling Liu ◽

Wei Chen ◽

Fan Yang ◽

Yong Xie ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Pyridine Moiety ◽

Structure Activity ◽

Relationship Of

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Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.02.015 ◽

2012 ◽

Vol 22 (9) ◽

pp. 3366-3369 ◽

Cited By ~ 3

Author(s):

Dramane I. Lainé ◽

Hongxing Yan ◽

Haibo Xie ◽

Roderick S. Davis ◽

Jeremy Dufour ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Design Synthesis ◽

Muscarinic Acetylcholine ◽

Structure Activity ◽

Relationship Of

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Design, synthesis and structure–activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.07.049 ◽

2013 ◽

Vol 69 ◽

pp. 115-124 ◽

Cited By ~ 21

Author(s):

Shadia A. Galal ◽

Ahmed S. Abdelsamie ◽

Salwa M. Soliman ◽

Jeremie Mortier ◽

Gerhard Wolber ◽

...

Keyword(s):

Tyrosine Kinase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Tyrosine Kinase Receptor ◽

Design Synthesis ◽

Chemopreventive Agent ◽

Structure Activity ◽

Quinoxaline Derivatives ◽

Relationship Of

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Triple reuptake inhibitors: Design, synthesis and structure–activity relationship of benzylpiperidine–tetrazoles

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.07.046 ◽

2017 ◽

Vol 25 (20) ◽

pp. 5278-5289 ◽

Cited By ~ 8

Author(s):

Suresh Paudel ◽

Xiao Min ◽

Srijan Acharya ◽

Daulat Bikram Khadka ◽

Goo Yoon ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.04.057 ◽

2007 ◽

Vol 17 (13) ◽

pp. 3595-3598 ◽

Cited By ~ 13

Author(s):

Nam-Jung Kim ◽

Kwang-Ok Lee ◽

Bon-Woong Koo ◽

Funan Li ◽

Ja-Kyung Yoo ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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