Synthesis and Stereochemical Structure−Activity Relationships of 1,3-Dioxoperhydropyrido[1,2-c]pyrimidine Derivatives:  Potent and Selective Cholecystokinin-A Receptor Antagonists

Mercedes Martín-Martínez; José M. Bartolomé-Nebreda; Isabel Gómez-Monterrey; Rosario González-Muñiz; M. Teresa García-López; Santiago Ballaz; Ana Barber; Ana Fortuño; Joaquín Del Río; Rosario Herranz

doi:10.1021/jm9703247

Synthesis and Stereochemical Structure−Activity Relationships of 1,3-Dioxoperhydropyrido[1,2-c]pyrimidine Derivatives: Potent and Selective Cholecystokinin-A Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm9703247 ◽

1997 ◽

Vol 40 (21) ◽

pp. 3402-3407 ◽

Cited By ~ 25

Author(s):

Mercedes Martín-Martínez ◽

José M. Bartolomé-Nebreda ◽

Isabel Gómez-Monterrey ◽

Rosario González-Muñiz ◽

M. Teresa García-López ◽

...

Keyword(s):

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Stereochemical Structure ◽

Structure Activity Relationships ◽

Structure Activity

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Structure−Activity Relationships of a Series of Pyrrolo[3,2-d]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm000269t ◽

2000 ◽

Vol 43 (22) ◽

pp. 4288-4312 ◽

Cited By ~ 64

Author(s):

Mark H. Norman ◽

Ning Chen ◽

Zhidong Chen ◽

Christopher Fotsch ◽

Clarence Hale ◽

...

Keyword(s):

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Related Compounds

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Synthesis, Molecular Pharmacology, and Structure–Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00442 ◽

2021 ◽

Author(s):

Harvey F. Fulo ◽

Amal Shoeib ◽

Christian V. Cabanlong ◽

Alexander H. Williams ◽

Chang-Guo Zhan ◽

...

Keyword(s):

Molecular Pharmacology ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure−Activity Relationships of 2-Substitutedd-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists: Importance of the C-2 Substituent of thed-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity

Journal of Medicinal Chemistry ◽

10.1021/jm9600914 ◽

1996 ◽

Vol 39 (12) ◽

pp. 2313-2330 ◽

Cited By ~ 14

Author(s):

Takehiro Fukami ◽

Takeru Yamakawa ◽

Kenji Niiyama ◽

Hisaki Kojima ◽

Yuuka Amano ◽

...

Keyword(s):

Tryptophan Residue ◽

Receptor Subtype ◽

Endothelin Receptor Antagonists ◽

Endothelin Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Subtype Selectivity ◽

Structure Activity ◽

Endothelin A

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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116019 ◽

2021 ◽

Vol 33 ◽

pp. 116019

Author(s):

Ikumi Kuriwaki ◽

Minoru Kameda ◽

Kazuhiko Iikubo ◽

Hiroyuki Hisamichi ◽

Yuichiro Kawamoto ◽

...

Keyword(s):

Systemic Exposure ◽

Pyrimidine Derivatives ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.01.096 ◽

2012 ◽

Vol 22 (6) ◽

pp. 2212-2215 ◽

Cited By ~ 26

Author(s):

A. Chris Krueger ◽

Darold L. Madigan ◽

David W. Beno ◽

David A. Betebenner ◽

Robert Carrick ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Pyrimidine Derivatives ◽

Structure Activity Relationships ◽

Structure Activity

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Selective endothelin A receptor antagonists. 2. Discovery and structure-activity relationships of 5-ketopentanoic acid derivatives

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)84014-7 ◽

1997 ◽

Vol 32 (6) ◽

pp. 515-522 ◽

Cited By ~ 8

Author(s):

P.C. Astles ◽

T.J. Brown ◽

N.V. Harris ◽

M.F. Harper ◽

C McCarthy ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Synthesis and structure–activity relationships of ( R )-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.02.004 ◽

2004 ◽

Vol 14 (9) ◽

pp. 2269-2274 ◽

Cited By ~ 14

Author(s):

Martin W Rowbottom ◽

Fabio C Tucci ◽

Yun-Fei Zhu ◽

Zhiqiang Guo ◽

Timothy D Gross ◽

...

Keyword(s):

Gnrh Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.05.051 ◽

2004 ◽

Vol 14 (15) ◽

pp. 4099-4102 ◽

Cited By ~ 31

Author(s):

Rosa Arienzo ◽

David E Clark ◽

Sue Cramp ◽

Stephen Daly ◽

Hazel J Dyke ◽

...

Keyword(s):

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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ChemInform Abstract: Indole Amide Derivatives: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies of a New Series of Histamine H1-Receptor Antagonists.

ChemInform ◽

10.1002/chin.199929124 ◽

2010 ◽

Vol 30 (29) ◽

pp. no-no

Author(s):

Sandra Battaglia ◽

Enrico Boldrini ◽

Federico Da Settimo ◽

Giulio Dondio ◽

Concettina La Motta ◽

...

Keyword(s):

Molecular Modeling ◽

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Studies ◽

Amide Derivatives ◽

Molecular Modeling Studies

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