High-Affinity α-Aminobutyric Acid A/Benzodiazepine Ligands:  Synthesis and Structure−Activity Relationship Studies of a New Series of Tetracyclic Imidazoquinoxalines†

John W. Mickelson; E. Jon Jacobsen; Donald B. Carter; Haesook K. Im; Wha Bin Im; Peggy J. K. D. Schreur; Vimala H. Sethy; Andy H. Tang; James E. McGee; James D. Petke

doi:10.1021/jm960401i

High-Affinity α-Aminobutyric Acid A/Benzodiazepine Ligands: Synthesis and Structure−Activity Relationship Studies of a New Series of Tetracyclic Imidazoquinoxalines†

Journal of Medicinal Chemistry ◽

10.1021/jm960401i ◽

1996 ◽

Vol 39 (23) ◽

pp. 4654-4666 ◽

Cited By ~ 30

Author(s):

John W. Mickelson ◽

E. Jon Jacobsen ◽

Donald B. Carter ◽

Haesook K. Im ◽

Wha Bin Im ◽

...

Keyword(s):

Structure Activity Relationship ◽

Aminobutyric Acid ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

Download Full-text

ChemInform Abstract: High-Affinity α-Aminobutyric Acid A/Benzodiazepine Ligands: Synthesis and Structure-Activity Relationship Studies of a New Series of Tetracyclic Imidazoquinoxalines.

ChemInform ◽

10.1002/chin.199708150 ◽

2010 ◽

Vol 28 (8) ◽

pp. no-no

Author(s):

J. W. MICKELSON ◽

E. J. JACOBSEN ◽

D. B. CARTER ◽

H. K. IM ◽

W. B. IM ◽

...

Keyword(s):

Structure Activity Relationship ◽

Aminobutyric Acid ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

Download Full-text

Azetidine derivatives as novel γ-aminobutyric acid uptake inhibitors: Synthesis, biological evaluation, and structure–activity relationship

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.02.029 ◽

2010 ◽

Vol 45 (6) ◽

pp. 2453-2466 ◽

Cited By ~ 25

Author(s):

Mark R. Faust ◽

Georg Höfner ◽

Jörg Pabel ◽

Klaus T. Wanner

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Aminobutyric Acid ◽

Activity Relationship ◽

Acid Uptake ◽

Structure Activity ◽

Uptake Inhibitors

Download Full-text

Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against hydrogen-bonding and provides an esterase-resistant, high-affinity cocaine

Journal of Medicinal Chemistry ◽

10.1021/jm00103a015 ◽

1992 ◽

Vol 35 (25) ◽

pp. 4764-4766 ◽

Cited By ~ 29

Author(s):

Alan P. Kozikowski ◽

Marinella Roberti ◽

Li Xiang ◽

John S. Bergmann ◽

Patrick M. Callahan ◽

...

Keyword(s):

Hydrogen Bonding ◽

Ester Group ◽

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

Download Full-text

ChemInform Abstract: Azetidine Derivatives as Novel γ-Aminobutyric Acid Uptake Inhibitors: Synthesis, Biological Evaluation, and Structure-Activity Relationship.

ChemInform ◽

10.1002/chin.201039222 ◽

2010 ◽

Vol 41 (39) ◽

pp. no-no

Author(s):

Mark R. Faust ◽

Georg Hoefner ◽

Joerg Pabel ◽

Klaus T. Wanner

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Aminobutyric Acid ◽

Activity Relationship ◽

Acid Uptake ◽

Structure Activity ◽

Uptake Inhibitors

Download Full-text

ChemInform Abstract: Structure-Activity Relationship Studies of CNS Agents. Part 26. 4-(2-( Cycloalkanecarboxamido)ethyl)-1-(2-methoxyphenyl)-piperazines: High- Affinity 5-HT1A Agonists

ChemInform ◽

10.1002/chin.199614177 ◽

2010 ◽

Vol 27 (14) ◽

pp. no-no

Author(s):

J. L. MOKROSZ ◽

M. H. PALUCHOWSKA ◽

A. KLODZINSKA ◽

S. CHARAKCHIEVA-MINOL ◽

E. CHOJNACKA-WOJCIK

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity ◽

Abstract Structure

Download Full-text

Structure-Activity Relationship Studies of CNS Agents, Part 26 4-[2-(Cycloalkanecarboxamido)ethyl]-1-(2-methoxyphenyl)-piperazines: High-Affinity 5-HT1A Agonists

Archiv der Pharmazie ◽

10.1002/ardp.19953281108 ◽

1995 ◽

Vol 328 (11-12) ◽

pp. 770-774 ◽

Cited By ~ 10

Author(s):

Jerzy L. Mokrosz ◽

Maria H. Paluchowska ◽

Aleksandra Klodzińska ◽

Sijka Charakchieva-Minol ◽

Ewa Chojnacka-Wójcik

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

High Affinity ◽

Structure Activity

Download Full-text

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides

Journal of Medicinal Chemistry ◽

10.1021/jm00083a014 ◽

1992 ◽

Vol 35 (5) ◽

pp. 895-903 ◽

Cited By ~ 17

Author(s):

R. D. Youssefyeh ◽

H. F. Campbell ◽

S. Klein ◽

J. E. Airey ◽

P. Darkes ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Initial Structure ◽

Receptor Antagonists ◽

High Affinity ◽

Structure Activity ◽

Relationship Of

Download Full-text

Structure–Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00924 ◽

2017 ◽

Vol 60 (21) ◽

pp. 8834-8846 ◽

Cited By ~ 11

Author(s):

Lars Jørgensen ◽

Anas Al-Khawaja ◽

Stefanie Kickinger ◽

Stine B. Vogensen ◽

Jonas Skovgaard-Petersen ◽

...

Keyword(s):

Molecular Modeling ◽

Structure Activity Relationship ◽

Aminobutyric Acid ◽

Activity Relationship ◽

Pharmacological Characterization ◽

Structure Activity ◽

Acid Transporter ◽

Noncompetitive Inhibitors

Download Full-text

(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship

Journal of Medicinal Chemistry ◽

10.1021/jm00079a008 ◽

1992 ◽

Vol 35 (1) ◽

pp. 67-72 ◽

Cited By ~ 17

Author(s):

Nandkishore Baindur ◽

Mai Tran ◽

Hyman B. Niznik ◽

H. C. Guan ◽

Phillip Seeman ◽

...

Keyword(s):

Dopamine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

High Affinity ◽

Dopamine Receptor Antagonists ◽

Structure Activity ◽

D1 Dopamine Receptor

Download Full-text

Quantitative Structure–Activity Relationship for High Affinity 5-HT1A Receptor Ligands Based on Norm Indexes

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.5b08980 ◽

2015 ◽

Vol 119 (51) ◽

pp. 15561-15567 ◽

Cited By ~ 17

Author(s):

Qingzhu Jia ◽

Xue Cui ◽

Lei Li ◽

Qiang Wang ◽

Ying Liu ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Ligands ◽

High Affinity ◽

Structure Activity

Download Full-text