Nonlinear Quantitative Structure−Activity Relationship for the Inhibition of Dihydrofolate Reductase by Pyrimidines

Jonathan D. Hirst

doi:10.1021/jm960197z

Nonlinear Quantitative Structure−Activity Relationship for the Inhibition of Dihydrofolate Reductase by Pyrimidines

Journal of Medicinal Chemistry ◽

10.1021/jm960197z ◽

1996 ◽

Vol 39 (18) ◽

pp. 3526-3532 ◽

Cited By ~ 16

Author(s):

Jonathan D. Hirst

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity

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Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth

Journal of Medicinal Chemistry ◽

10.1021/jm00390a017 ◽

1987 ◽

Vol 30 (7) ◽

pp. 1218-1224 ◽

Cited By ~ 24

Author(s):

Raymond G. Booth ◽

Cynthia Dias Selassie ◽

Corwin Hansch ◽

Daniel V. Santi

Keyword(s):

Cell Growth ◽

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: INHIBITION OF HUMAN DIHYDROFOLATE REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(SUBSTITUTED-PHENYL)-S-TRIAZINES. A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS

Chemischer Informationsdienst ◽

10.1002/chin.198429225 ◽

1984 ◽

Vol 15 (29) ◽

Author(s):

B. A. HATHAWAY ◽

Z. GUO ◽

C. HANSCH ◽

T. J. DELCAMP ◽

S. S. SUSTEN ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity ◽

Human Dihydrofolate Reductase

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Quantitative Structure Activity Relationship Study of 2,4,6-Trisubstituted-s-triazine Derivatives as Antimalarial Inhibitors of Plasmodium Falciparum Dihydrofolate Reductase

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2010.01045.x ◽

2010 ◽

Vol 77 (1) ◽

pp. 57-62 ◽

Cited By ~ 16

Author(s):

Himanshu Ojha ◽

Pragya Gahlot ◽

Anjani K. Tiwari ◽

Mallika Pathak ◽

Rita Kakkar

Keyword(s):

Plasmodium Falciparum ◽

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Triazine Derivatives ◽

Relationship Study

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ChemInform Abstract: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP OF 5-(X-BENZYL)-2,4-DIAMINOPYRIMIDINES INHIBITING BOVINE LIVER DIHYDROFOLATE REDUCTASE

Chemischer Informationsdienst ◽

10.1002/chin.197941238 ◽

1979 ◽

Vol 10 (41) ◽

Author(s):

J. M. BLANEY ◽

S. W. DIETRICH ◽

M. A. REYNOLDS ◽

C. HANSCH

Keyword(s):

Dihydrofolate Reductase ◽

Bovine Liver ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP BY DISTANCE GEOMETRY: QUINAZOLINES AS DIHYDROFOLATE REDUCTASE INHIBITORS

Chemischer Informationsdienst ◽

10.1002/chin.198304225 ◽

1983 ◽

Vol 14 (4) ◽

Author(s):

A. K. GHOSE ◽

G. M. CRIPPEN

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Dihydrofolate Reductase Inhibitors

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The method of frontal polyhedra for conformationally-nonrigid molecules. Quantitative structure—Activity relationship in the series of baker triazines—Dihydrofolate reductase inhibitors

Pharmaceutical Chemistry Journal ◽

10.1007/bf02464669 ◽

1997 ◽

Vol 31 (3) ◽

pp. 147-154 ◽

Cited By ~ 1

Author(s):

A. I. Khlebnikov

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Nonrigid Molecules ◽

Reductase Inhibitors ◽

Structure Activity ◽

Dihydrofolate Reductase Inhibitors

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Quantitative structure-activity relationship by distance geometry: quinazolines as dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00350a003 ◽

1982 ◽

Vol 25 (8) ◽

pp. 892-899 ◽

Cited By ~ 29

Author(s):

Arup K. Ghose ◽

Gordon M. Crippen

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Dihydrofolate Reductase Inhibitors

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Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. A quantitative structure-activity relationship analysis

Journal of Medicinal Chemistry ◽

10.1021/jm00368a007 ◽

1984 ◽

Vol 27 (2) ◽

pp. 144-149 ◽

Cited By ~ 14

Author(s):

Bruce A. Hathaway ◽

Zong Ru Guo ◽

Corwin Hansch ◽

Tavner J. Delcamp ◽

Sandra S. Susten ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity ◽

Human Dihydrofolate Reductase

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A Molecular shape analysis and quantitative structure-activity relationship investigation of some triazine-antifolate inhibitors of Leishmania dihydrofolate reductase

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(88)90245-7 ◽

1988 ◽

Vol 266 (1) ◽

pp. 152-161 ◽

Cited By ~ 6

Author(s):

M.G. Koehler ◽

K. Rowberg-Schaefer ◽

A.J. Hopfinger

Keyword(s):

Shape Analysis ◽

Dihydrofolate Reductase ◽

Molecular Shape ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity

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ChemInform Abstract: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP OF REVERSIBLE DIHYDROFOLATE REDUCTASE INHIBITORS, DIAMINOTRIAZINES

Chemischer Informationsdienst ◽

10.1002/chin.197446330 ◽

1974 ◽

Vol 5 (46) ◽

pp. no-no

Author(s):

C. HANSCH ◽

C. SILIPO

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Relationship Of ◽

Dihydrofolate Reductase Inhibitors

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