Searching for New NO-Donor Aspirin-like Molecules: A New Class of Nitrooxy-acyl Derivatives of Salicylic Acid†

2008 ◽  
Vol 51 (6) ◽  
pp. 1894-1903 ◽  
Author(s):  
Loretta Lazzarato ◽  
Monica Donnola ◽  
Barbara Rolando ◽  
Elisabetta Marini ◽  
Clara Cena ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
No Donor ◽  
New Class ◽  
Derivatives Of ◽  
Acyl Derivatives

scholarly journals Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

2011 ◽  
Vol 19 (19) ◽  
pp. 5852-5860 ◽  
Author(s):  
Loretta Lazzarato ◽  
Clara Cena ◽  
Barbara Rolando ◽  
Elisabetta Marini ◽  
Marco Lucio Lolli ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
No Donor ◽  
Derivatives Of

scholarly journals Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4872
Author(s):  
Tena Čadež ◽  
Ana Grgičević ◽  
Ramiza Ahmetović ◽  
Danijela Barić ◽  
Nikolina Maček Hrvat ◽  
...  
Keyword(s):  
Ring Opening ◽  
Structural Adjustment ◽  
Cholinesterase Inhibitors ◽  
Furan Ring ◽  
Phenyl Substituent ◽  
Oxime Ether ◽  
New Class ◽  
Further Development ◽  
Derivatives Of ◽  
Acyl Derivatives

A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The majority of the tested compounds exhibited higher selectivity for BChE. Structural adjustment for AChE seems to have been achieved by acylation, and the furan ring opening of furo-benzobicyclo[3.2.1]octadiene results for compound 51 with the highest AChE affinity (IC50 = 8.3 µM). Interestingly, its analogue, an oxime ether with a benzobicyclo[3.2.1]-skeleton, compound 32 was one of the most potent BChE inhibitors in this study (IC50 = 31 µM), but not as potent as endo-43, an ether derivative of the benzobicyclo[3.2.1]octene with an additional phenyl substituent (IC50 = 17 µM). Therefore, we identified several cholinesterase inhibitors with a potential for further development as potential drugs for the treatment of neurodegenerative diseases.

Structure, stability, and antiplatelet activity of O-acyl derivatives of salicylic acid and lipophilic esters of acetylsalicylate

2009 ◽  
Vol 61 (3) ◽  
pp. 476-489 ◽  
Author(s):  
Ilya B. Zavodnik ◽  
Elena Lapshina ◽  
Elena Sudnikovich ◽  
Magdalena Boncler ◽  
Bogusława Luzak ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Structure Stability ◽  
Antiplatelet Activity ◽  
Derivatives Of ◽  
Acyl Derivatives
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