scholarly journals Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

2011 ◽  
Vol 19 (19) ◽  
pp. 5852-5860 ◽  
Author(s):  
Loretta Lazzarato ◽  
Clara Cena ◽  
Barbara Rolando ◽  
Elisabetta Marini ◽  
Marco Lucio Lolli ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
No Donor ◽  
Derivatives Of

Searching for New NO-Donor Aspirin-like Molecules: A New Class of Nitrooxy-acyl Derivatives of Salicylic Acid†

2008 ◽  
Vol 51 (6) ◽  
pp. 1894-1903 ◽  
Author(s):  
Loretta Lazzarato ◽  
Monica Donnola ◽  
Barbara Rolando ◽  
Elisabetta Marini ◽  
Clara Cena ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
No Donor ◽  
New Class ◽  
Derivatives Of ◽  
Acyl Derivatives

Nitric Oxide-Donating Derivatives of Chrysin Stimulate Angiogenesis and Upregulating VEGF Production

2011 ◽  
Vol 340 ◽  
pp. 363-368 ◽  
Author(s):  
Xiao Qing Zou ◽  
Yong Lan Ding ◽  
Sheng Ming Peng ◽  
Chang Ping Hu ◽  
Han Wu Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Therapeutic Option ◽  
Therapeutic Angiogenesis ◽  
Vegf Mrna ◽  
No Donor ◽  
Endothelial Migration ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Angiogenesis, the development of new capillaries from pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate to form functional vessels. Endothelial dysfunction and decreased nitric oxide bioavailability may underscore the impairment of angiogenesis. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to therapeutic angiogenesis. In this paper, a novel group of hybrid nitric oxide-releasing chrysin derivatives was synthesized. The results indicated that all these chrysin derivatives exhibited promotion of endothelial migration and tubulogenesis in vitro as well as stimulation angiogenesis in vivo.Furthermore, all compounds released NO upon incubation with phosphate buffer at pH 7.4 and enhanced VEGF secretion and VEGF mRNA expression of endothelial cells. These hybrid ester NO donor prodrugs offer a potential drug design concept for the development of therapeutic or preventive agents for angiogenesis deficiency due to ischemic diseases.

ChemInform Abstract: β-Hydroxyamide Derivatives of Salicylic Acid as Organocatalysts for Enantioselective Reductions of Prochiral Ketones.

ChemInform ◽  
2013 ◽  
Vol 44 (50) ◽  
pp. no-no
Author(s):  
Vilmaz Turgut ◽  
Murat Azizoglu ◽  
Asli Erdogan ◽  
Nevin Arslan ◽  
Halil Hosgoren
Keyword(s):  
Salicylic Acid ◽  
Prochiral Ketones ◽  
Derivatives Of

Synthesis and structure of new derivatives of salicylic acid hydrazide

2014 ◽  
Vol 84 (9) ◽  
pp. 1857-1859 ◽  
Author(s):  
O. A. Nurkenov ◽  
S. D. Fazylov ◽  
Zh. B. Satpaeva ◽  
T. M. Seilkhanov ◽  
G. Zh. Karipova ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Acid Hydrazide ◽  
Derivatives Of

Derivatives of salicylic acid

1937 ◽  
Vol 5 (4) ◽  
pp. 377-380
Author(s):  
N. W. Hirwe ◽  
K. D. Gavanker
Keyword(s):  
Salicylic Acid ◽  
Derivatives Of

ChemInform Abstract: 1,2,3-Triazole Derivatives of Salicylic Acid.

1984 ◽  
Vol 15 (20) ◽  
Author(s):  
A. DA SETTIMO ◽  
O. LIVI ◽  
G. BIAGI ◽  
A. LUCACCHINI ◽  
S. CASELLI
Keyword(s):  
Salicylic Acid ◽  
Triazole Derivatives ◽  
Derivatives Of

scholarly journals Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis

2010 ◽  
Vol 76 (2) ◽  
pp. 85-99 ◽  
Author(s):  
Zunnan Huang ◽  
Yantao He ◽  
Xian Zhang ◽  
Andrea Gunawan ◽  
Li Wu ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Yersinia Pestis ◽  
Derivatives Of
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