Design and Synthesis of 4-Substituted Indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidine Derivatives with Antitumor Activity

2008 ◽  
Vol 51 (7) ◽  
pp. 2037-2046 ◽  
Author(s):  
Antonino Lauria ◽  
Chiara Patella ◽  
Gaetano Dattolo ◽  
Anna Maria Almerico
Keyword(s):  
Antitumor Activity ◽  
Pyrimidine Derivatives ◽  
Design And Synthesis

Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities

2016 ◽  
Vol 12 (8) ◽  
pp. 311-317
Author(s):  
Kamelia El-Mahdy
Keyword(s):  
Antitumor Activity ◽  
Spectroscopic Data ◽  
Acid Hydrazide ◽  
Chloroacetic Acid ◽  
Equimolar Amount ◽  
Unsaturated Ketone ◽  
Cyanoacetic Acid ◽  
Antitumor Activities ◽  
Pyrimidine Derivatives ◽  
Cyanoacetic Acid Hydrazide

Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, respectively. The detailed synthesis, spectroscopic data, and antitumor activity for synthesized compounds were reported.

Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative Agents

2015 ◽  
Vol 36 (7) ◽  
pp. 1863-1873 ◽  
Author(s):  
Ahmed Elkamhawy ◽  
Mohammad M. Al-Sanea ◽  
Chiman Song ◽  
Taebo Sim ◽  
Eun Joo Roh
Keyword(s):  
Pyrimidine Derivatives ◽  
Antiproliferative Agents ◽  
Design And Synthesis

New pyrazolo-triazolo-pyrimidine derivatives as antibacterial agents: Design and synthesis, molecular docking and DFT studies

2020 ◽  
Vol 1199 ◽  
pp. 127007 ◽  
Author(s):  
Mabrouk Horchani ◽  
Amel Hajlaoui ◽  
Abdel Halim Harrath ◽  
Lamjed Mansour ◽  
Hichem Ben Jannet ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antibacterial Agents ◽  
Dft Studies ◽  
Pyrimidine Derivatives ◽  
Design And Synthesis

Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish

2019 ◽  
Vol 234 (9) ◽  
pp. 16431-16446 ◽  
Author(s):  
Gang Wang ◽  
Qi Xiao ◽  
Yao Wu ◽  
Ying‐jie Wei ◽  
Yue Jing ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Hepatoma Cells ◽  
Design And Synthesis ◽  
Antiangiogenic Activity

ChemInform Abstract: PYRIMIDINE DERIVATIVES. XLIV. SOME 5,6-DIHYDROURACILS AND THIOURACILS AND STUDY OF THEIR ANTITUMOR ACTIVITY

1977 ◽  
Vol 8 (28) ◽  
pp. no-no
Author(s):  
M. A. KALDRIKYAN ◽  
V. A. GEBOYAN ◽  
F. G. ARSENYAN ◽  
B. T. GARIBDZHANYAN ◽  
A. A. AROYAN
Keyword(s):  
Antitumor Activity ◽  
Pyrimidine Derivatives

Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest

2014 ◽  
Vol 83 ◽  
pp. 155-166 ◽  
Author(s):  
Mohamed Fares ◽  
Sahar Mahmoud Abou-Seri ◽  
Hatem A. Abdel-Aziz ◽  
Safinaz E.-S. Abbas ◽  
Mohieldin Magdy Youssef ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Pyrimidine Derivatives ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest
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