Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Christopher M. McBride; Barry Levine; Yi Xia; Cornelia Bellamacina; Timothy Machajewski; Zhenhai Gao; Paul Renhowe; William Antonios-McCrea; Paul Barsanti; Kristin Brinner; Abran Costales; Brandon Doughan; Xiaodong Lin; Alicia Louie; Maureen McKenna; Kris Mendenhall; Daniel Poon; Alice Rico; Michael Wang; Teresa E. Williams; Tinya Abrams; Susan Fong; Thomas Hendrickson; Dachuan Lei; Julie Lin; Daniel Menezes; Nancy Pryer; Pietro Taverna; Yongjin Xu; Yasheen Zhou; Cynthia M. Shafer

doi:10.1021/jm501107q

Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Journal of Medicinal Chemistry ◽

10.1021/jm501107q ◽

2014 ◽

Vol 57 (21) ◽

pp. 9124-9129 ◽

Cited By ~ 12

Author(s):

Christopher M. McBride ◽

Barry Levine ◽

Yi Xia ◽

Cornelia Bellamacina ◽

Timothy Machajewski ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Design Structure ◽

In Vivo Characterization

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In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm070276i ◽

2007 ◽

Vol 50 (15) ◽

pp. 3651-3660 ◽

Cited By ~ 19

Author(s):

Richard J. Perner ◽

Stanley DiDomenico ◽

John R. Koenig ◽

Arthur Gomtsyan ◽

Erol K. Bayburt ◽

...

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Activity Relationship ◽

Transient Receptor Potential Vanilloid ◽

Structure Activity ◽

Transient Receptor ◽

In Vivo Characterization

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Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.01.050 ◽

2013 ◽

Vol 21 (7) ◽

pp. 1756-1763 ◽

Cited By ~ 22

Author(s):

Martine Keenan ◽

Paul W. Alexander ◽

Hugo Diao ◽

Wayne M. Best ◽

Andrea Khong ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Efficacy ◽

Structure Activity ◽

Design Structure

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Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm800790t ◽

2009 ◽

Vol 52 (2) ◽

pp. 278-292 ◽

Cited By ~ 94

Author(s):

Paul A. Renhowe ◽

Sabina Pecchi ◽

Cynthia M. Shafer ◽

Timothy D. Machajewski ◽

Elisa M. Jazan ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Structure Activity ◽

Design Structure ◽

In Vivo Characterization ◽

Receptor Tyrosine Kinase Inhibitors

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STRUCTURE-ACTIVITY RELATIONSHIP OF VARIOUS ANALOGUES OF β-CORTICOTRROPHIN DETERMINED BY REFERENCE TO VARIOUS PARAMETERS IN VITRO AND IN VIVO

Acta Endocrinologica ◽

10.1530/acta.0.061s029 ◽

1969 ◽

Vol 61 (1_Suppl) ◽

pp. S29

Author(s):

Pierre A. Desaulles ◽

René Maier ◽

Matthys Staehelin

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: Structure-Activity Relationship for Antineoplastic Imidazoacridinones: Synthesis and Antileukemic Activity in vivo.

ChemInform ◽

10.1002/chin.199627168 ◽

2010 ◽

Vol 27 (27) ◽

pp. no-no

Author(s):

W. M. CHOLODY ◽

B. HOROWSKA ◽

J. PARADZIEJ-LUKOWICZ ◽

S. MARTELLI ◽

J. KONOPA

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Antileukemic Activity ◽

Structure Activity ◽

Abstract Structure

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Microscale characterization of the structure–activity relationship of a heparin-binding glycopeptide using affinity capillary electrophoresis and immobilized enzymes

Journal of Chromatography A ◽

10.1016/s0021-9673(99)00452-5 ◽

1999 ◽

Vol 853 (1-2) ◽

pp. 189-195 ◽

Cited By ~ 11

Author(s):

Niels H.H Heegaard

Keyword(s):

Capillary Electrophoresis ◽

Immobilized Enzymes ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Heparin Binding ◽

Affinity Capillary Electrophoresis ◽

Structure Activity ◽

Relationship Of

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nSynthesis and characterization of 1-amidino-O-alkylureas metal complexes as α- glucosidase Inhibitors: Structure-activity relationship, molecular docking, and kinetic studies

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131726 ◽

2021 ◽

pp. 131726

Author(s):

Firouz Matloubi Moghaddam ◽

Maryam Daneshfar ◽

Zahra Daneshfar ◽

Aida Iraji ◽

Atefe Samandari-Najafabad ◽

...

Keyword(s):

Molecular Docking ◽

Metal Complexes ◽

Kinetic Studies ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Glucosidase Inhibitors

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Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study

Acta Pharmaceutica Sinica B ◽

10.1016/j.apsb.2018.12.008 ◽

2019 ◽

Vol 9 (2) ◽

pp. 351-368 ◽

Cited By ~ 1

Author(s):

Peng Wei ◽

Bo Liu ◽

Ruifeng Wang ◽

Yinglei Gao ◽

Lanlan Li ◽

...

Keyword(s):

Structural Characterization ◽

Structure Activity Relationship ◽

In Vivo Study ◽

Activity Relationship ◽

Structure Activity ◽

Scaffold Structure ◽

Crystal Structural

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Quantitative structure–activity relationship (QSAR) for insecticides: development of predictive in vivo insecticide activity models

SAR and QSAR in Environmental Research ◽

10.1080/10629360903278735 ◽

2009 ◽

Vol 20 (5-6) ◽

pp. 551-566 ◽

Cited By ~ 10

Author(s):

P.K. Naik ◽

Sindhura ◽

T. Singh ◽

H. Singh

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Insecticide Activity ◽

Activity Models

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Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Journal of Medicinal Chemistry ◽

10.1021/jm010523x ◽

2002 ◽

Vol 45 (8) ◽

pp. 1697-1711 ◽

Cited By ~ 305

Author(s):

Le Wang ◽

Keith W. Woods ◽

Qun Li ◽

Kenneth J. Barr ◽

Richard W. McCroskey ◽

...

Keyword(s):

Antitumor Activity ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Activity Evaluation ◽

Structure Activity ◽

In Vivo Antitumor Activity ◽

Orally Active

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