A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi

2013 ◽  
Vol 56 (14) ◽  
pp. 5773-5781 ◽  
Author(s):  
Özlen Güzel-Akdemir ◽  
Atilla Akdemir ◽  
Peiwen Pan ◽  
Alane B. Vermelho ◽  
Seppo Parkkila ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Trypanosoma Cruzi ◽  
Inhibitory Action ◽  
Strong Inhibitory Action

scholarly journals Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX

Molecules ◽  
2018 ◽  
Vol 23 (1) ◽  
pp. 153 ◽  
Author(s):  
Aikaterini Peperidou ◽  
Silvia Bua ◽  
Murat Bozdag ◽  
Dimitra Hadjipavlou-Litina ◽  
Claudiu Supuran
Keyword(s):  
Carbonic Anhydrase ◽  
Inhibitory Action ◽  
Carbonic Anhydrase Ix ◽  
Substituted Coumarins

scholarly journals Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action

2017 ◽  
Vol 32 (1) ◽  
pp. 701-706 ◽  
Author(s):  
Marco Bragagni ◽  
Fabrizio Carta ◽  
Sameh M. Osman ◽  
Zeid AlOthman ◽  
Claudiu T. Supuran
Keyword(s):  
Carbonic Anhydrase ◽  
Acridine Orange ◽  
Inhibitory Action ◽  
Carbonic Anhydrase Ix ◽  
Sulfonamide Derivative

scholarly journals Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors

2021 ◽  
Vol 22 (20) ◽  
pp. 11119
Author(s):  
Moataz Shaldam ◽  
Alessio Nocentini ◽  
Zainab M. Elsayed ◽  
Tamer M. Ibrahim ◽  
Rofaida Salem ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Carbonic Anhydrase ◽  
Cell Lines ◽  
Inhibitory Activity ◽  
Inhibitory Action ◽  
Docking Simulation ◽  
Simulation Studies ◽  
Molecular Docking Simulation ◽  
Anchoring Group ◽  
Mcf 7

A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4-anilinoquinoline scaffold where the primary sulphonamide functionality was grafted at C4 of the anilino moiety as a zinc anchoring group (QBS 13a–c); thereafter, the sulphonamide group was switched to ortho- and meta-positions to afford regioisomers 9a–d and 11a–g. Moreover, a linker elongation approach was adopted where the amino linker was replaced by a hydrazide one to afford QBS 16. All the described QBS have been synthesized and investigated for their CA inhibitory action against hCA I, II, IX and XII. In general, para-sulphonamide derivatives 13a–c displayed the best inhibitory activity against both cancer-related isoforms hCA IX (KIs = 25.8, 5.5 and 18.6 nM, respectively) and hCA XII (KIs = 9.8, 13.2 and 8.7 nM, respectively), beside the excellent hCA IX inhibitory activity exerted by meta-sulphonamide derivative 11c (KI = 8.4 nM). The most promising QBS were further evaluated for their anticancer and pro-apoptotic activities on two cancer cell lines (MDA-MB-231 and MCF-7). In addition, molecular docking simulation studies were applied to justify the acquired CA inhibitory action of the target QBS.

Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II

2012 ◽  
Vol 28 (2) ◽  
pp. 294-298 ◽  
Author(s):  
Cemalettin Alp ◽  
Alfonso Maresca ◽  
Nurdan Alcan Alp ◽  
Mehmet Serdar Gültekin ◽  
Deniz Ekinci ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Inhibitory Action ◽  
Human Carbonic Anhydrase

scholarly journals Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action

2017 ◽  
Vol 60 (7) ◽  
pp. 3154-3164 ◽  
Author(s):  
Fabrizio Carta ◽  
Alexander Birkmann ◽  
Tamara Pfaff ◽  
Helmut Buschmann ◽  
Wilfried Schwab ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Inhibitory Action

Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis γ-carbonic anhydrase

2014 ◽  
Vol 24 (16) ◽  
pp. 4006-4010 ◽  
Author(s):  
Mariangela Ceruso ◽  
Sonia Del Prete ◽  
Zeid AlOthman ◽  
Sameh M. Osman ◽  
Andrea Scozzafava ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Porphyromonas Gingivalis ◽  
Inhibitory Action
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