Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability

Junjie Fu; Ling Liu; Zhangjian Huang; Yisheng Lai; Hui Ji; Sixun Peng; Jide Tian; Yihua Zhang

doi:10.1021/jm400393u

Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability

Journal of Medicinal Chemistry ◽

10.1021/jm400393u ◽

2013 ◽

Vol 56 (11) ◽

pp. 4641-4655 ◽

Cited By ~ 42

Author(s):

Junjie Fu ◽

Ling Liu ◽

Zhangjian Huang ◽

Yisheng Lai ◽

Hui Ji ◽

...

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Oleanolic Acid ◽

Human Hepatocellular Carcinoma ◽

Hybrid Molecule ◽

Glutathione S Transferase ◽

Improved Stability

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Correction to “Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability”

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01778 ◽

2019 ◽

Vol 62 (22) ◽

pp. 10473-10473

Author(s):

Junjie Fu ◽

Ling Liu ◽

Zhangjian Huang ◽

Yisheng Lai ◽

Hui Ji ◽

...

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Oleanolic Acid ◽

Human Hepatocellular Carcinoma ◽

Hybrid Molecule ◽

Glutathione S Transferase ◽

Improved Stability

Download Full-text

Faculty Opinions recommendation of Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: a glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718003270.793480072 ◽

2013 ◽

Author(s):

Larry K Keefer

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Oleanolic Acid ◽

Human Hepatocellular Carcinoma ◽

Hybrid Molecule ◽

Glutathione S Transferase ◽

Improved Stability

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Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid

Organic & Biomolecular Chemistry ◽

10.1039/b918846k ◽

2010 ◽

Vol 8 (3) ◽

pp. 632-639 ◽

Cited By ~ 41

Author(s):

Zhangjian Huang ◽

Yihua Zhang ◽

Li Zhao ◽

Yongwang Jing ◽

Yisheng Lai ◽

...

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Oleanolic Acid ◽

Human Hepatocellular Carcinoma ◽

Nitric Oxide Releasing ◽

Derivatives Of

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Glutathione S-Transferase in Human Hepatocellular Carcinoma

Hepatology ◽

10.1002/hep.1840030206 ◽

2007 ◽

Vol 3 (2) ◽

pp. 170-176 ◽

Cited By ~ 16

Author(s):

Morris Sherman ◽

John A. H. Campbell ◽

Sally A. Titmuss ◽

Michael C. Kew ◽

Ralph E. Kirsch

Keyword(s):

Hepatocellular Carcinoma ◽

Human Hepatocellular Carcinoma ◽

Glutathione S Transferase

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Octreotide and opioids reduce the rate of proliferation of human hepatocellular carcinoma (HCC) cell line HEPG2, with parallel increase of nitric oxide (NO) production

Journal of Hepatology ◽

10.1016/s0168-8278(03)80412-9 ◽

2003 ◽

Vol 38 ◽

pp. 103

Author(s):

G. Notas ◽

M. Kampa ◽

A. Vasilaki ◽

C. Xidakis ◽

V. Valatas ◽

...

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Cell Line ◽

Human Hepatocellular Carcinoma ◽

No Production ◽

Parallel Increase

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Effects of nitric oxide on the biological behavior of HepG2 human hepatocellular carcinoma cells

Experimental and Therapeutic Medicine ◽

10.3892/etm.2016.3128 ◽

2016 ◽

Vol 11 (5) ◽

pp. 1875-1880 ◽

Cited By ~ 11

Author(s):

LEI ZHOU ◽

HENG ZHANG ◽

JIE WU

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Biological Behavior ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells

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NOAD, a novel nitric oxide donor, induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells

Toxicology in Vitro ◽

10.1016/j.tiv.2015.05.003 ◽

2015 ◽

Vol 29 (7) ◽

pp. 1289-1297 ◽

Cited By ~ 16

Author(s):

Ling Liu ◽

Dongmei Wang ◽

Jiangang Wang ◽

Hui Ji ◽

Yihua Zhang

Keyword(s):

Nitric Oxide ◽

Hepatocellular Carcinoma ◽

Human Hepatocellular Carcinoma ◽

Nitric Oxide Donor ◽

Phase Arrest ◽

M Phase

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Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells

Biochemical Pharmacology ◽

10.1016/j.bcp.2016.08.011 ◽

2016 ◽

Vol 118 ◽

pp. 9-17 ◽

Cited By ~ 18

Author(s):

Matthias Lange ◽

Behnaz Ahangarian Abhari ◽

Tobias M. Hinrichs ◽

Simone Fulda ◽

Juliane Liese

Keyword(s):

Oxidative Stress ◽

Hepatocellular Carcinoma ◽

Cell Death ◽

Oleanolic Acid ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells

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Oleanolic Acid and Ursolic Acid Induce Apoptosis in HuH7 Human Hepatocellular Carcinoma Cells through a Mitochondrial-Dependent Pathway and Downregulation of XIAP

Journal of Agricultural and Food Chemistry ◽

10.1021/jf100574j ◽

2010 ◽

Vol 58 (10) ◽

pp. 6110-6118 ◽

Cited By ~ 111

Author(s):

Ming-Huan Shyu ◽

Tzu-Chien Kao ◽

Gow-Chin Yen

Keyword(s):

Hepatocellular Carcinoma ◽

Ursolic Acid ◽

Oleanolic Acid ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells ◽

Dependent Pathway

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Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents

Organic & Biomolecular Chemistry ◽

10.1039/c2ob25252j ◽

2012 ◽

Vol 10 (19) ◽

pp. 3882 ◽

Cited By ~ 14

Author(s):

Zhangjian Huang ◽

Junjie Fu ◽

Ling Liu ◽

Yijun Sun ◽

Yisheng Lai ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Oleanolic Acid ◽

Biological Evaluation ◽

Human Hepatocellular Carcinoma

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